Strain Analysis as a Right Ventricle Contractility Marker
30 oktober 2019 uppdaterad av: Hospices Civils de Lyon
The analysis of the systolic function (contractility) of the right ventricle (RV) is fundamental and central in many pathologies in intensive care unit.
It can guide physicians in choosing therapeutics.
The conventional ultrasound markers of RV function evaluation currently used are influenced by RV loading conditions, impairing their capacity to approximate a true contractility analysis.
Myocardial strain imaging is a recent echographic technique that allows, among other things, to evaluate RV systolic function.
It is a reproducible index with early variations which, if it proved to be independent pre-load, would help to better appreciate the RV contractility.
Studieöversikt
Status
Avslutad
Betingelser
Intervention / Behandling
Studietyp
Interventionell
Inskrivning (Faktisk)
16
Fas
- Inte tillämpbar
Kontakter och platser
Det här avsnittet innehåller kontaktuppgifter för dem som genomför studien och information om var denna studie genomförs.
Studieorter
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Lyon, Frankrike, 69004
- Hôpital de La Croix Rousse
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Lyon, Frankrike, 69007
- Hôpital Saint Joseph Saint Luc
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Deltagandekriterier
Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.
Urvalskriterier
Åldrar som är berättigade till studier
18 år och äldre (Vuxen, Äldre vuxen)
Tar emot friska volontärer
Nej
Kön som är behöriga för studier
Allt
Beskrivning
Inclusion Criteria:
- Male or female ≥ 18 years
- Patients with renal failure treated with intermittent hemodialysis
- Patients who received an information and did not opposed to participate in the study, or, if unconscious patient at the time of inclusion: a person of trust as defined in Article L. 1111-6 of the Public Health Code, failing that, the family or, failing that, a person maintaining stable link, having received information and not opposed to participate in the study.
Exclusion Criteria:
- Patients with heart disease (valvular, ischemic, rhythmic)
- Patients with ejection fraction of left ventricular altered <45%
- Chronic dialysis patients
Patients referred in Articles L. 1121-5, L.1121-6, L.1121-7, L.1121-8 of the Public Health Code:
- Pregnant women, parturients or nursing mothers
- Persons deprived of their liberty by a judicial or administrative decision, persons subject to psychiatric care, persons admitted to a health or social institution for purposes other than research
- Minor Patients
- Major persons who are subject to a legal protection measure or are unable to express their consent
- Patients not willing to participate in the study
- Patients not affiliated to a social security
Studieplan
Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.
Hur är studien utformad?
Designdetaljer
- Primärt syfte: Diagnostisk
- Tilldelning: N/A
- Interventionsmodell: Enskild gruppuppgift
- Maskning: Ingen (Open Label)
Vapen och interventioner
Deltagargrupp / Arm |
Intervention / Behandling |
|---|---|
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Övrig: ultrasound measurements
ultrasound measurements of myocardial deformation of free wall right ventricle during a sharp decline of right ventricle preload induced during a session of Intermittent hemodialysis.
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ultrasound measurements of myocardial deformation of free wall right ventricle at 4 time points during a session of intermittent hemodialysis : before the intermittent hemodialysis connection, just after starting hemodialysis, after 1 hour of hemodialysis and 5 minutes before restitution
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Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
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Evaluation of the change in the Longitudinal strain of the free wall right ventricle
Tidsram: at baseline, 1 minute after starting hemodialysis, 1 hour after, and 5 minutes before restitution
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measurements will be performed using an ultrasound device usually used in our center for the hemodynamic monitoring of patients in intensive care by transthoracic cardiac ultrasound
|
at baseline, 1 minute after starting hemodialysis, 1 hour after, and 5 minutes before restitution
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Sekundära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
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Evaluation of the change in S' right ventricle wave
Tidsram: at baseline, 1 minute after starting hemodialysis, 1 hour after, and 5 minutes before restitution
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measurements will be performed using an ultrasound device usually used in our center for the hemodynamic monitoring of patients in intensive care by transthoracic cardiac ultrasound
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at baseline, 1 minute after starting hemodialysis, 1 hour after, and 5 minutes before restitution
|
|
Evaluation of the change in tricuspid annular plane systolic excursion (TAPSE)
Tidsram: at baseline, 1 minute after starting hemodialysis, 1 hour after, and 5 minutes before restitution
|
measurements will be performed using an ultrasound device usually used in our center for the hemodynamic monitoring of patients in intensive care by transthoracic cardiac ultrasound
|
at baseline, 1 minute after starting hemodialysis, 1 hour after, and 5 minutes before restitution
|
|
Evaluation of the change in visual left ventricular ejection fraction (LVEF)
Tidsram: at baseline, 1 minute after starting hemodialysis, 1 hour after, and 5 minutes before restitution
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measurements will be performed using an ultrasound device usually used in our center for the hemodynamic monitoring of patients in intensive care by transthoracic cardiac ultrasound
|
at baseline, 1 minute after starting hemodialysis, 1 hour after, and 5 minutes before restitution
|
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Evaluation of the change in mitral E wave
Tidsram: at baseline, 1 minute after starting hemodialysis, 1 hour after, and 5 minutes before restitution
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measurements will be performed using an ultrasound device usually used in our center for the hemodynamic monitoring of patients in intensive care by transthoracic cardiac ultrasound
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at baseline, 1 minute after starting hemodialysis, 1 hour after, and 5 minutes before restitution
|
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Evaluation of the change in mitral A wave
Tidsram: at baseline, 1 minute after starting hemodialysis, 1 hour after, and 5 minutes before restitution
|
measurements will be performed using an ultrasound device usually used in our center for the hemodynamic monitoring of patients in intensive care by transthoracic cardiac ultrasound
|
at baseline, 1 minute after starting hemodialysis, 1 hour after, and 5 minutes before restitution
|
|
Evaluation of the change in wave E ' at the lateral mitral ring
Tidsram: at baseline, 1 minute after starting hemodialysis, 1 hour after, and 5 minutes before restitution
|
measurements will be performed using an ultrasound device usually used in our center for the hemodynamic monitoring of patients in intensive care by transthoracic cardiac ultrasound
|
at baseline, 1 minute after starting hemodialysis, 1 hour after, and 5 minutes before restitution
|
|
Evaluation of the change in systolic fraction of pulmonary venous flow
Tidsram: at baseline, 1 minute after starting hemodialysis, 1 hour after, and 5 minutes before restitution
|
measurements will be performed using an ultrasound device usually used in our center for the hemodynamic monitoring of patients in intensive care by transthoracic cardiac ultrasound
|
at baseline, 1 minute after starting hemodialysis, 1 hour after, and 5 minutes before restitution
|
|
inter individual variability of Longitudinal strain of the free wall right ventricle
Tidsram: at baseline, 1 minute after starting hemodialysis, 1 hour after, and 5 minutes before restitution
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Each measurement will be performed by two blind operators
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at baseline, 1 minute after starting hemodialysis, 1 hour after, and 5 minutes before restitution
|
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intra individual variability of Longitudinal strain of the free wall right ventricle
Tidsram: at baseline, 1 minute after starting hemodialysis, 1 hour after, and 5 minutes before restitution
|
Each measurement will be performed by two blind operators
|
at baseline, 1 minute after starting hemodialysis, 1 hour after, and 5 minutes before restitution
|
Samarbetspartners och utredare
Det är här du hittar personer och organisationer som är involverade i denna studie.
Sponsor
Utredare
- Huvudutredare: Zoé Schmitt, Hôpital de la Croix-Rousse
Studieavstämningsdatum
Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.
Studera stora datum
Studiestart (Faktisk)
25 november 2016
Primärt slutförande (Faktisk)
31 december 2017
Avslutad studie (Faktisk)
31 december 2017
Studieregistreringsdatum
Först inskickad
10 mars 2017
Först inskickad som uppfyllde QC-kriterierna
20 mars 2017
Första postat (Faktisk)
24 mars 2017
Uppdateringar av studier
Senaste uppdatering publicerad (Faktisk)
31 oktober 2019
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
30 oktober 2019
Senast verifierad
1 oktober 2019
Mer information
Termer relaterade till denna studie
Nyckelord
Ytterligare relevanta MeSH-villkor
Andra studie-ID-nummer
- 69HCL16-0370
Läkemedels- och apparatinformation, studiedokument
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