Emotion and Attention in Alzheimer's Disease (ATEMMA) (ATEMMA)

Inclusion Criteria:

• Healthy volunteers :

  • Affiliation to social security
  • Medical examination before study participation
  • No contraindication to MRI
  • Informed consent signed
  • Young adults older than 18 years and younger than 40 years
  • Healthy old adults older than 65 years and younger than 95 years
  • Visual acuity allowing normal perception of stimuli or corrected to normal vision

• Patients with Alzheimer's Disease :

  • Affiliation to social security
  • Medical examination before study participation
  • No contraindication to MRI
  • Informed consent signed
  • Patients with Alzheimer's Disease at mild or moderate stage (National Institute on Aging and Alzheimer's Association criteria), diagnosed at Grenoble CMRR (Centre Mémoire de Ressources et de Recherche)
  • Patients older than 65 years and younger than 95 years
  • MMSE (Mini-Mental State Examination) > 18/30
  • Ability to understand study instructions and give an informed consent
  • Visual acuity allowing normal perception of stimuli or corrected to normal vision

Exclusion Criteria:

• Every participant having a vascular stent implanted less than 6 weeks before study
• Every participant having a biomedical material implanted that is considered "unsafe" in the list: http://www.mrisafety.com/TheList_search.asp
• Every acquisition procedure not respecting required conditions by the "conditional" usage in a participant having a biomedical material implanted that is considered "conditional" in the list: http://www.mrisafety.com/TheList_search.asp
• Every subject having a biomedical material such as a cardiac, neuronal or sensorial stimulator (cochlear implant because of demagnetization, electrode heating or artefact risk) or a ventricular drain without trained medical or paramedical support during MRI for these participants
• Ferromagnetic object inside the eye or the skull, close to nervous structures (displacement and complications risk such as eye or brain damage)
• Claustrophobia
• Psychiatric (e.g., bipolar disorder) or neurological pathology (e.g., epilepsy, Parkinson's Disease) other than Alzheimer's Disease
• Non cooperating participant
• Severe and uncontrolled affection: cardiac, respiratory, haematological, renal, hepatic, cancerous
• Participation to other research protocols with exclusion period or MRI during the past weel
• Drug therapy likely to modulate brain activity : neuroleptics, lithium, etc...
• Alcohol ingestion before study
• Participants concerned by articles L1125-5 to L1121-8 of CSP (Code de la Santé Publique) (pregnant or nursing women, underage or protected adult, person under administrative or judicial oversight
• Participant receiving more than 4500 euros for his participation to other studies involving human person during the past 12 months before this study
• Participant unable to be contacted in case of emergency
• Inability to understand study instructions or give an informed consent