Effects of Adolescent Synaptic Pruning (SPA PET)
4 maj 2026 uppdaterad av: Beatriz Luna
The study will use a PET-based measure of brain cell (neuron) connections (synapses) in young adults who have also obtained an MRI, to assess how the loss of brain cell connections (synaptic pruning) is captured by MRI-based measures.
This will inform youth MRI studies to understand neurotypical brain development that can help identify abnormal trajectories as in mental illness.
Studieöversikt
Status
Anmälan via inbjudan
Betingelser
Intervention / Behandling
Detaljerad beskrivning
The loss of brain cell (neuron) connections (synapses) through human development, known as synaptic pruning, has been characterized in postmortem studies but how this proceeds in live humans as they age into adulthood is not well understood.
This study will use the PET tracer [11C]UCB-J which provides a direct measure of synaptic density, in conjunction with previously acquired ultra-high field MRI, in a group of young adults in order to understand how standard MRI-based measures reflect changes in the density of synapses.
PET [11C]UCB-J is known to measure the density of synaptic connections by measuring a protein (SV2A) present in synapses.
A comparison of results from the current study with MRI-based measures of byproducts of synaptic membrane breakdown from childhood to early adulthood will allow assessment of how non-invasive MRI reflects synaptic pruning through development, facilitating studies of how the brain changes through adolescence and into adulthood, which is needed to identify patterns of development associated with the emergence of mental illness.
Studietyp
Interventionell
Inskrivning (Beräknad)
60
Fas
- Inte tillämpbar
Kontakter och platser
Det här avsnittet innehåller kontaktuppgifter för dem som genomför studien och information om var denna studie genomförs.
Studieorter
-
-
Pennsylvania
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Pittsburgh, Pennsylvania, Förenta staterna, 15213
- Laboratory of Neurocognitive Development
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Deltagandekriterier
Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.
Urvalskriterier
Åldrar som är berättigade till studier
- Vuxen
- Äldre vuxen
Tar emot friska volontärer
Ja
Beskrivning
Inclusion Criteria:
- Males or females between 18-26 years of age, AND currently enrolled in the Parent Project (R01MH067924)
Exclusion Criteria: (these exclusion criteria are outlined in the Parent Project)
- Head injury with loss of consciousness over an hour.
- A vision problem or eye movement problem (such as lazy eye, double vision, blurred vision, or color blindness).
- A learning disability and/or ever had an Individualized Education Plan (IEP) in school.
- Significant neurological or metabolic illness: Epilepsy, Meningitis, Encephalitis, Diabetes, Huntington's disease.
- Diagnosed with a psychiatric disorder.
- Participants with, or with a first degree relative, having a DSM IV Axis l psychiatricdisorder.
- Metal implants or ferromagnetic objects contained within the body which may interfere with the MRI scan (but not limited to, those with a pacemaker, presence of metallic fragments near the eyes or spinal cord, or cochlear implant.) Dental fillings do not present a risk for MRI. If there is a possibility of metal being present in the participant's body, the participant will be excluded from the study.
- Weight more than 250 pounds.
- Claustrophobia or uncomfortable in small spaces.
- <70% on the Achenbach scale (either from Youth Self Report (YSR) or Adult Self Report (ASR)).
- IQ < 80 or IQ > 130.
- Pregnancy or lactation, lack of effective birth control during 15 days before the scans.
- Currently employed as radiation worker; or participation in radioactive drug research protocols within the previous year such that the total cumulative annual radiation dose (i.e., from participation in the previous radioactive drug study [studies] and this study) would exceed the radiation dose limits specified in the FDA regulations (i.e., 21 CFR 361.1) that govern the research use of [C-11]UCB-J
- History of drug or alcohol abuse (from parent study eligibility).
Studieplan
Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.
Hur är studien utformad?
Designdetaljer
- Primärt syfte: Grundläggande vetenskap
- Tilldelning: N/A
- Interventionsmodell: Enskild gruppuppgift
- Maskning: Ingen (Open Label)
Vapen och interventioner
Deltagargrupp / Arm |
Intervention / Behandling |
|---|---|
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Experimentell: PET Imaging Supplemental Component
Adult participants enrolled in the parent study, will be given the option to be a part of the PET imaging supplemental project.
Maximum enrollment is 60 adult participants.
Interested participants will be consented into the PET portion, and will have a single PET scan (as outlined in the Study Description section).
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[11C]UCB-J (~ 15 mCi and ≤ 6μg) will be injected as a slow intravenous bolus.
Following an intravenous bolus injection of [11C]UCB-J, the participants will be positioned in the scanner for a low dose CT scan (for attenuation correction) fifty-five minutes after the [11C]UCB-J injection, and emission data will be collected.
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Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
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Non-invasive quantification of synaptic pruning
Tidsram: The PET-CT scan will be within approximately 30 days of the parent study MRI.
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1. Age-related changes in synaptic density through young adulthood o Cross-sectional age-related (18-26 years of age) changes in synaptic density via SUVR quantified within the dorsolateral prefrontal cortex. |
The PET-CT scan will be within approximately 30 days of the parent study MRI.
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Non-invasive quantification of synaptic pruning
Tidsram: The PET-CT scan will be within approximately 30 days of the parent study MRI.
|
2. Within-subject associations of synapse density to MRI-derived measures of brain membrane byproducts o Synaptic density, based on SUVR modeling of [11C]UCB-J acquisitions, will be compared to ultra-high field (7 Tesla) [31P]MRSI measurement of membrane phospholipid levels obtained from the same participants. |
The PET-CT scan will be within approximately 30 days of the parent study MRI.
|
Samarbetspartners och utredare
Det är här du hittar personer och organisationer som är involverade i denna studie.
Sponsor
Samarbetspartners
Utredare
- Huvudutredare: Beatriz Luna, PhD, University of Pittsburgh
Studieavstämningsdatum
Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.
Studera stora datum
Studiestart (Faktisk)
9 januari 2026
Primärt slutförande (Beräknad)
30 juni 2028
Avslutad studie (Beräknad)
30 juni 2028
Studieregistreringsdatum
Först inskickad
27 april 2026
Först inskickad som uppfyllde QC-kriterierna
4 maj 2026
Första postat (Faktisk)
6 maj 2026
Uppdateringar av studier
Senaste uppdatering publicerad (Faktisk)
6 maj 2026
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
4 maj 2026
Senast verifierad
1 maj 2026
Mer information
Termer relaterade till denna studie
Nyckelord
Ytterligare relevanta MeSH-villkor
Andra studie-ID-nummer
- STUDY24060023
- 3R01MH067924-19S1 (U.S.S. NIH-anslag/kontrakt)
Plan för individuella deltagardata (IPD)
Planerar du att dela individuella deltagardata (IPD)?
JA
IPD-planbeskrivning
Individual [11C]UCB-J SUVR maps will be shared via the NIH Data Archive (NDA), along with basic corresponding demographic data (age, sex).
Tidsram för IPD-delning
Upon completion of the study.
Kriterier för IPD Sharing Access
Access of shared IPD is managed by the NIH Data Archive.
IPD-delning som stöder informationstyp
- STUDY_PROTOCOL
Läkemedels- och apparatinformation, studiedokument
Studerar en amerikansk FDA-reglerad läkemedelsprodukt
Nej
Studerar en amerikansk FDA-reglerad produktprodukt
Nej
Denna information hämtades direkt från webbplatsen clinicaltrials.gov utan några ändringar. Om du har några önskemål om att ändra, ta bort eller uppdatera dina studieuppgifter, vänligen kontakta register@clinicaltrials.gov. Så snart en ändring har implementerats på clinicaltrials.gov, kommer denna att uppdateras automatiskt även på vår webbplats .