Effects of Oral Collagen Drinks on Human Skin
8 juli 2026 uppdaterad av: TCI Co., Ltd.
The objective of this study is to evaluate the effect of oral collagen drink and MAXI collagen drink on human skin condition improvement.
Studieöversikt
Status
Avslutad
Betingelser
Intervention / Behandling
Detaljerad beskrivning
This study is a single-center, double-blinded, parallel human trial designed to evaluate the skin beauty effect of oral collagen drink and MAXI collagen drink.
Healthy adult participants aged 18-60 years will be enrolled. Participants will be informed to consume test samples daily for 4 consecutive weeks. Skin measurement and self-assessment questionnaires will be conducted at baseline (before intake), after 1 week, and 4 weeks of consumption.
Studietyp
Interventionell
Inskrivning (Faktisk)
105
Fas
- Inte tillämpbar
Kontakter och platser
Det här avsnittet innehåller kontaktuppgifter för dem som genomför studien och information om var denna studie genomförs.
Studieorter
-
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Beijing, Kina
- Beijing Ewish Testing Technology Co.,ltd.
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Deltagandekriterier
Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.
Urvalskriterier
Åldrar som är berättigade till studier
- Vuxen
Tar emot friska volontärer
Ja
Beskrivning
Inclusion Criteria:
- Healthy Chinese subjects aged 18 to 60 years, both male and female.
- Wrinkle Severity: Crow's feet graded 2-4; under-eye fine lines graded 2-5; nasolabial folds graded 1-3.
- Presence of facial skin laxity and sagging.
- Ability to undergo skin examinations and pre-treatment in the designated test areas.
- Ability to understand the trial process, participate voluntarily, and sign a written Informed Consent Form (ICF).
Exclusion Criteria:
- Pregnant or lactating women, or those planning to become pregnant in the near future.
- Highly sensitive constitution, history of allergic diseases, or history of allergies to cosmetics.
- Presence of skin diseases (e.g., psoriasis, eczema, atopic dermatitis, severe acne) or other chronic systemic diseases.
- Skin conditions in the test area such as birthmarks, hyperpigmentation, inflammation, scars, nevi (moles), or hypertrichosis (excessive hair).
- Use of anti-inflammatory drugs (e.g., oral or topical corticosteroids) within the past month.
- Use of cosmetics or other products with similar efficacy within the past 2 weeks.
- Participation in other human clinical trials for cosmetics within the past month.
- Any other conditions deemed unsuitable for participation based on clinical assessment.
Studieplan
Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.
Hur är studien utformad?
Designdetaljer
- Primärt syfte: Behandling
- Tilldelning: Randomiserad
- Interventionsmodell: Parallellt uppdrag
- Maskning: Dubbel
Vapen och interventioner
Deltagargrupp / Arm |
Intervention / Behandling |
|---|---|
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Aktiv komparator: Collagen Drink
oral intake 5 g collagen daily
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consume 1 bottle of the test samples daily for 4 consecutive weeks, each bottle containing 5 g Collagen Powder
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Experimentell: MAXI Collagen Drink
oral intake 15 mL MAXI collagen daily (equivalent to 5 g of deep hydrolyzed collagen net weight)
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consume 1 bottle of the test samples daily for 4 consecutive weeks, each bottle containing 15 mL MAXI Collagen Liquid (equivalent to 5 g of deep hydrolyzed collagen net weight)
|
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Experimentell: MAXI Collagen Drink_High dose
oral intake 30 mL MAXI collagen daily (equivalent to 10 g of deep hydrolyzed collagen net weight)
|
consume 1 bottle of the test samples daily for 4 consecutive weeks, each bottle containing 30 mL MAXI Collagen Liquid (equivalent to 10 g of deep hydrolyzed collagen net weight)
|
Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
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The change of collagen fiber fluorescence intensity
Tidsram: Change from Baseline collagen intensity at 4 weeks
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SUPERVISION-780 In-Vivo Imaging System (Survface, China) was utilized to evaluate the density and quality of dermal collagen fibers.
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Change from Baseline collagen intensity at 4 weeks
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Sekundära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
The change of skin elasticity
Tidsram: Change from Baseline skin elasticity at 4 weeks
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Cutometer® MPA580 (CK, Germany) was utilized to measure the gross elasticity of the skin using suction method.
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Change from Baseline skin elasticity at 4 weeks
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The change of skin firmness
Tidsram: Change from Baseline skin firmness at 4 weeks
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Cutometer® MPA580 (CK, Germany) was utilized to measure skin firmness and the area under the suction curve.
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Change from Baseline skin firmness at 4 weeks
|
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The change of epidermal thickness
Tidsram: Change from Baseline epidermal thickness at 4 weeks
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SUPERVISION-780 In-Vivo Imaging System (Survface, China) was utilized to measure the depth of the epidermal layer using optical imaging.
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Change from Baseline epidermal thickness at 4 weeks
|
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The change of cheek skin roughness
Tidsram: Change from Baseline skin roughness at 4 weeks
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AEVA-HE (EOTECH, France) was utilized to measure the arithmetic average roughness (Ra value) of the cheek surface.
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Change from Baseline skin roughness at 4 weeks
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The change of the Dermal-Epidermal Junction (DEJ) structures
Tidsram: Change from Baseline DEJ status at 4 weeks
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SUPERVISION-780 In-Vivo Imaging System (Survface, China) was utilized to assess the structural integrity and epithelial-connective tissue interface (ECTI) of the DEJ.
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Change from Baseline DEJ status at 4 weeks
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The change of nasolabial folds volume
Tidsram: Change from Baseline wrinkle parameters at 4 weeks
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AEVA-HE (EOTECH, France) was utilized to quantify the 3D morphological changes of the nasolabial folds volume.
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Change from Baseline wrinkle parameters at 4 weeks
|
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The change of nasolabial folds depth
Tidsram: Change from Baseline wrinkle parameters at 4 weeks
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AEVA-HE (EOTECH, France) was utilized to quantify the 3D morphological changes of the nasolabial folds depth.
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Change from Baseline wrinkle parameters at 4 weeks
|
|
The change of crow's feet volume
Tidsram: Change from Baseline crow's feet parameters at 4 weeks
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AEVA-HE (EOTECH, France) was utilized to measure the severity of crow's feet volume.
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Change from Baseline crow's feet parameters at 4 weeks
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The change of crow's feet depth
Tidsram: Change from Baseline crow's feet parameters at 4 weeks
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AEVA-HE (EOTECH, France) was utilized to measure the severity of crow's feet depth.
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Change from Baseline crow's feet parameters at 4 weeks
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The change of the volume of fine lines under the eyes
Tidsram: Change from Baseline fine lines at 4 weeks
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AEVA-HE (EOTECH, France) was utilized to assess the volume of fine lines under the eyes.
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Change from Baseline fine lines at 4 weeks
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The change of the mean depth of fine lines under the eyes
Tidsram: Change from Baseline fine lines at 4 weeks
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AEVA-HE (EOTECH, France) was utilized to assess the mean depth of fine lines under the eyes.
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Change from Baseline fine lines at 4 weeks
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The change of cheek (malar) volume
Tidsram: Change from Baseline cheek volume at 4 weeks
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AEVA-HE (EOTECH, France) was utilized to measure the 3D volume of the cheek area for lifting effects.
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Change from Baseline cheek volume at 4 weeks
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The change of jawline length
Tidsram: Change from Baseline jawline parameters at 4 weeks
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AEVA-HE (EOTECH, France) was utilized to measure the linear length and contour of the jawline.
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Change from Baseline jawline parameters at 4 weeks
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The change of skin pores counts
Tidsram: Change from Baseline pore parameters at 4 weeks
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AEVA-HE (EOTECH, France) was utilized to perform 3D imaging and quantification of skin pores counts.
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Change from Baseline pore parameters at 4 weeks
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The change of skin pores volume
Tidsram: Change from Baseline pore parameters at 4 weeks
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AEVA-HE (EOTECH, France) was utilized to perform 3D imaging and quantification of skin pores volume.
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Change from Baseline pore parameters at 4 weeks
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The change of skin hydration
Tidsram: Change from Baseline skin hydration at 4 weeks
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Corneometer® CM825 (CK, Germany) was utilized to measure skin surface hydration.
Units: arbitrary Corneometer® units 0-120.
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Change from Baseline skin hydration at 4 weeks
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The change of transepidermal water loss (TEWL)
Tidsram: Change from Baseline TEWL at 4 weeks
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Tewameter® TM300 (CK, Germany) was utilized to measure the evaporation rate of water from the skin.
Units: g/h/m^2.
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Change from Baseline TEWL at 4 weeks
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Andra resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
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The change of skin brightness (L*)
Tidsram: Change from Baseline skin brightness (L*) at 4 weeks
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Skin-Colorimeter CL400 (CK, Germany) was utilized to measure skin brightness (L*).
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Change from Baseline skin brightness (L*) at 4 weeks
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The change of skin individual typology angle (ITA)
Tidsram: Change from Baseline skin ITA at 4 weeks
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Skin-Colorimeter CL400 (CK, Germany) was utilized to measure skin individual typology angle (ITA).
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Change from Baseline skin ITA at 4 weeks
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The change of skin color parameters
Tidsram: Change from Baseline skin redness (a*) at 4 weeks
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Skin-Colorimeter CL400 (CK, Germany) was utilized to measure skin redness (a*).
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Change from Baseline skin redness (a*) at 4 weeks
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The change of skin color parameters
Tidsram: Change from Baseline skin yellow tone (b*) at 4 weeks
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Skin-Colorimeter CL400 (CK, Germany) was utilized to measure skin yellow tone (b*).
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Change from Baseline skin yellow tone (b*) at 4 weeks
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Samarbetspartners och utredare
Det är här du hittar personer och organisationer som är involverade i denna studie.
Sponsor
Utredare
- Huvudutredare: YAO PAN, Beijing Ewish Testing Technology Co.,ltd.
Studieavstämningsdatum
Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.
Studera stora datum
Studiestart (Faktisk)
12 maj 2026
Primärt slutförande (Faktisk)
15 juni 2026
Avslutad studie (Faktisk)
30 juni 2026
Studieregistreringsdatum
Först inskickad
8 maj 2026
Först inskickad som uppfyllde QC-kriterierna
18 maj 2026
Första postat (Faktisk)
26 maj 2026
Uppdateringar av studier
Senaste uppdatering publicerad (Faktisk)
10 juli 2026
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
8 juli 2026
Senast verifierad
1 juli 2026
Mer information
Termer relaterade till denna studie
Nyckelord
Ytterligare relevanta MeSH-villkor
Andra studie-ID-nummer
- SECCR2025-254
Läkemedels- och apparatinformation, studiedokument
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