Long-Term Study of Cerebral Glucose Metabolism in Huntington's Disease
OBJECTIVES: I. Correlate clinical outcome with cerebral glucose metabolism in patients with Huntington's disease (HD) and their at-risk relatives.
II. Evaluate the efficacy of cerebral glucose metabolism in observing the pathophysiologic development of HD, monitoring responses to experimental therapy, and predicting HD genotype.
III. Identify, define, and describe the natural history of pathophysiologic lesions in HD.
IV. Characterize the genotypic and phenotypic expression of the HD gene.
研究概览
地位
条件
详细说明
PROTOCOL OUTLINE: Participants are screened for Huntington's disease, including cerebral glucose metabolism assessment and genetic testing.
Studies include a detailed family history and neurologic, psychometric, and neurobehavioral evaluations. Imaging includes positron emission tomography with fluorodeoxyglucose and brain magnetic resonance imaging.
A genotype assessment is performed; genetic results are not disclosed to patients or relatives.
研究类型
注册
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
PROTOCOL ENTRY CRITERIA:
--Disease Characteristics--
- Documented family history of Huntington's disease (HD)
- Symptomatic HD: chorea required
- At-risk for HD: no detectable systemic or oculomotor abnormality
- Age-matched control subjects
- No history of inherited neurological disease
- No general or neurologic abnormality
--Prior/Concurrent Therapy--
At least 4 weeks since other HD treatment, e.g.:
- Haloperidol
- Benzodiazepine
- Other tranquilizers or neuroleptics
--Patient Characteristics--
- No pregnant women
学习计划
研究是如何设计的？
合作者和调查者
合作者
调查人员
- 学习椅：John C. Mazziotta、University of California, Los Angeles
研究记录日期
研究主要日期
学习开始
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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