Acute, Affective, Organic Disorders.
Signs of Organic Brain Dysfunction in Psychiatric Patients With Fluctuating Psychiatric Symptoms Including Brief Depressions Compared to Patients With a Major Depressive Episode.
研究概览
地位
条件
详细说明
A limited number of patients admitted to psychiatric acute wards or Psychiatric Intensive Care Units are admitted with a fluctuating array of psychiatric symptoms including brief depressive episodes. These patients do not fit into the present diagnostic systems due to short duration of affective symptoms and the fluctuating arrays of other symptoms. Case histories indicate that these patients have psychiatric conditions due to epilepsy or organic brain dysfunctions.
In the study acutely admitted patients filling criteria for two recent DSM-4 axis 1 diagnoses (one is a brief depressive period) during the last two weeks are compared to age- and sex-matched patients acutely admitted with a major depressive disorder. The patients are rated with a number of rating scales at admittance, day 5, after two weeks and three months. EEG and QEEG are taken three times the first week. MRI, drug screening and blood screening of medication-concentrations are taken.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Trondheim、挪威、7441
- Østmarka Psychiatric Department, St. Olavs Hospital
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Acutely admitted psychiatric patients who have at different times the last 2 weeks filled criteria for at least two new DSM-4 Axis 1 psychiatric diagnoses. One of them has to be a depressive episode (MADRS>20)
Exclusion Criteria:
- Patients not speaking Norwegian or English.
- Patients not willing to participate.
- Patients with dementia or mental retardation to an extensive degree.
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
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严重抑郁症
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brief depressive periods
brief depressive periods together with other fluctuating psychiatric symptoms
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
---|---|---|
epilepsy or an other organic brain disorder
大体时间:1 week
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EEG and QEEG are taken three times in the first week
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1 week
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合作者和调查者
合作者
调查人员
- 学习椅:Olav M Linaker, Professor、Norwegian University of Science and Technology
出版物和有用的链接
一般刊物
- Vaaler AE, Morken G, Iversen VC, Kondziella D, Linaker OM. Acute Unstable Depressive Syndrome (AUDS) is associated more frequently with epilepsy than major depression. BMC Neurol. 2010 Jul 30;10:67. doi: 10.1186/1471-2377-10-67.
- Vaaler AE, Morken G, Linaker OM, Sand T, Kvistad KA, Brathen G. Symptoms of epilepsy and organic brain dysfunctions in patients with acute, brief depression combined with other fluctuating psychiatric symptoms: a controlled study from an acute psychiatric department. BMC Psychiatry. 2009 Sep 30;9:63. doi: 10.1186/1471-244X-9-63.
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- AEV-98
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