Adrenal Exhaustion Syndrome in Critically Ill Patients Without Improvement
Change of Serum Cortisol Levels in Patients Without Improvement in Intensive Care Unit
研究概览
地位
条件
详细说明
Elevated corticosteroid level to meet physiologic needs during acute illness is a protective response for stress. This homeostasis is maintained by the hypothalamic-pituitary-adrenal (HPA) axis. However, inadequate response as corticosteroid insufficiency in critically ill patients is reported with increasing frequency, especially in severe sepsis and septic shock. Thus, corticosteroids could be beneficial for septic shock or severe acute illness.
Once considered as normal adrenal function, adrenal insufficiency may developed later with chronic critical illness as adrenal exhaustion syndrome. It is easily overlooked and is possible due to the chronic secretion of systemic cytokines or other HPA axis-suppressive substances. There is still no consensus how often adrenal function testing should be repeated, although a re-evaluation should be considered if clinical symptoms and signs suggest adrenal insufficiency or deteriorating clinical condition.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Taipei、台湾、100
- Chao-Chi Ho
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- age over 18
- ICU admission
- had two cortisol data
Exclusion Criteria:
- first cortisol data abnormal
- cortisol data not checked in ICU
学习计划
研究是如何设计的?
设计细节
合作者和调查者
调查人员
- 研究主任:Chao-Chi Ho, MD、1. Department of Internal Medicine, National Taiwan University Hospital
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- 200802022R
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