Mechanisms of Severe Acute Influenza Consortium (MOSAIC) (MOSAIC)
研究概览
地位
条件
详细说明
Influenza A is one of the best studied viruses, but continues to have a very large impact on human and animal health. In addition to causing outbreaks of winter flu, it sometimes mutates to create a new virus that spreads quickly around the world. It is puzzling that the same virus appears to cause minor or absent symptoms in some people while killing others. Much remains to be understood.
The investigators have assembled an unprecedented group of internationally renowned scientists from England and Scotland who will together focus on studying a few hundred people hospitalised during the current swine flu pandemic. Such a large scale project has never before been attempted, but we are now poised to work together and integrate the many recent advances in biomedical science that relate to understanding how influenza causes disease.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Liverpool、英国、L7 8XP
- Royal Liverpool University Hospital
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Liverpool、英国、L8 7SS
- Liverpool Women's NHS Foundation Trust
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Liverpool、英国、L12 2AP
- Alder Hey Children's Foundation NHS Trust
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Liverpool、英国、L9 7AL
- Aintree Hospitals NHS Trust
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London、英国、SW3 6NP
- Royal Brompton and Harefield NHS Foundation Trust
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London、英国、SW10 9NH
- Chelsea and Westminster Hospital NHS Foundation Trust
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London、英国、W2 1PG
- Imperial College Healthcare NHS Trust
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Wirral、英国、CH49 5PE
- Wirral University Teaching Hospital NHS Foundation Trust
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参与标准
资格标准
适合学习的年龄
- 孩子
- 成人
- 年长者
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Any patient admitted to hospital with suspected or confirmed influenza infection
Exclusion Criteria:
- Patients who do not give their consent
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
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Influenza diagnosis
Patients admitted to hospital with a suspected or confirmed influenza diagnosis on admission
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研究衡量的是什么?
主要结果指标
结果测量 |
大体时间 |
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Detailed clinical phenotype. Clinicopathological correlation will then be sought between the clinical phenotype and pathological parameters measured as per work packages.
大体时间:3 years
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3 years
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次要结果测量
结果测量 |
大体时间 |
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Response to drug treatment and the effect of drug resistance if that emerges.
大体时间:3 years
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3 years
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合作者和调查者
调查人员
- 首席研究员:Peter JM Openshaw、Imperial College London
出版物和有用的链接
一般刊物
- Dunning J, Blankley S, Hoang LT, Cox M, Graham CM, James PL, Bloom CI, Chaussabel D, Banchereau J, Brett SJ, Moffatt MF, O'Garra A, Openshaw PJM; MOSAIC Investigators. Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza. Nat Immunol. 2018 Jun;19(6):625-635. doi: 10.1038/s41590-018-0111-5. Epub 2018 May 18. Erratum In: Nat Immunol. 2019 Mar;20(3):373.
- Dunning J, Blankley S, Hoang LT, Cox M, Graham CM, James PL, Bloom CI, Chaussabel D, Banchereau J, Brett SJ; MOSAIC Investigators; Moffatt MF, O'Garra A, Openshaw PJM. Author Correction: Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza. Nat Immunol. 2019 Mar;20(3):373. doi: 10.1038/s41590-019-0328-y.
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- CRO1367
- 09/H0709/52 (其他标识符:English Research Ethics Committee)
- 09/MRE00/67 (其他标识符:Scottish Research Ethics Committee)
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)?
药物和器械信息、研究文件
研究美国 FDA 监管的药品
研究美国 FDA 监管的设备产品
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