Effect of Food Form on Satiety and Gastric Emptying
Beverages and Obesity: Effect of Food Form on Satiety and Hunger
Our objective is to determine whether food form (liquid vs. solid) alters gastric emptying, satiety, and food intake, when all macronutrients and fiber are controlled. The study population will include 10 healthy women, who have a normal body mass index. We have chosen to evaluate only women because this is a small pilot study and one of our endpoints is gastric emptying. Gastric emptying is known to differ between men and women. Gastric emptying will be evaluated using the Smartpill technology, satiety will be evaluated using computerized visual analog scales/questions, and food intake will be measured by providing subjects with an ad libitum/buffet-style lunch.
Our hypothesis is that our subjects will be less hungry after they eat a solid breakfast compared to a liquid breakfast. We also hypothesize that our subjects will have a slower gastric emptying time after they eat the solid meal. Lastly, we think subjects will want to eat less food at lunch time if they have eaten a solid meal compared to a liquid meal for breakfast.
研究概览
研究类型
注册 (实际的)
联系人和位置
学习地点
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Minnesota
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Saint Paul、Minnesota、美国、55108
- University of Minnesota
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Healthy women
- Age 18 - 35
- Body mass index in the healthy range between 18.5 and 25
- Proficient English speakers
- Non-smoking
- Not taking medications
- Non-dieting (weight stable over last 3 months)
- Able to swallow a large capsule
Exclusion Criteria:
- Irregular or erratic breakfast eating patterns
- Food allergies to ingredients commonly found in test products or pizza
- Distaste for test products or pizza
- BMI less than 18.5 or greater than 25
- Weight change > 5 kg in last 3 months (intentional or unintentional)
- Difficulty swallowing
- Cardiovascular disease
- Diabetes mellitus (fasting blood sugar > 126 mg/dl)
- Cancer in prior 5 years (except basal cell carcinoma of skin)
- Kidney or liver disease
- Any gastrointestinal conditions that may affect digestion and absorption
- Recent bacterial infection (< 3 months)
- Chronic medication use
- History of drug or alcohol abuse in prior 6 months
- Concurrent or recent intervention study participation
- Vegetarians or people who ate more than approximately 15 g of fiber per day
- Pregnant or lactating women
- Women with irregular menstrual cycles
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
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Liquid Meal
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The liquid breakfast meal will contain 370 calories and will consist of fruit juices and skim milk
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Solid Meal
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The solid breakfast will contain 370 calories and will consist of oatmeal, golden delicious apples, blueberries, skim milk, and brown sugar.
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Determine whether food form (liquid vs. solid) alters gastric emptying time when all macronutrients and fiber are controlled.
大体时间：May 2010 to December 2010
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Subjects will consume both liquid and solid meals and we will evaluate and compare gastric emptying time after each of them.
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May 2010 to December 2010
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Determine whether food form (liquid vs. solid) alters satiety and food intake when all macronutrients and fiber are controlled.
大体时间：May 2010 to December 2010
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Subjects will consume both liquid and solid meals and we will evaluate and compare appetite and food intake after each of them.
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May 2010 to December 2010
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合作者和调查者
调查人员
- 首席研究员：Holly J Willis, PhD、University of Minnesota
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- 1003M78873
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