To Evaluate Effectiveness and Safety of Containing Raltegravir in Naive HIV NON B or B Infected Patients (Ral'inNONB)

It's a pilot open label, multicentric, national, prospective and descriptive study to evaluate effectiveness and safety of regimen containing Raltegravir (400mg x 2) in 40 treatment naive HIV non B infected subjects versus in 20 treatment naive HIV B infected sujects.

The patients will be matched according to:

• basal viral load (< 10 000 copies/ml, ≥100 000 copies/ml)
• rate of basal CD4 (<200 cell/mm3, ≥ 200 cell/mm3)

Inclusion Criteria:

• In order to be eligible to take part in this study, patients should meet all of the following criteria:

Patient aged at least 18 years; Treatment naive patient infected with HIV-1; Patients indicated for treatment containing raltegravir Patient has at least 2 activates molecules in combination therapy according genotype realized in the visit of selection.

Patient has not a history or current evidence of opportunist infection within the 4 weeks before the selection Patient who has received oral and written (information sheet) information about the study and who has agreed for the computer processing of his/her personal data.

Patients with chronic hepatitis, including chronic hepatitis B and/or C may enter the study as.

Exclusion Criteria:

• Patients meeting one or both of the following criteria may not take part in the study
• Patient is reproductive potential without requiring the use of contraception
• Patient is pregnant or breast-feeding
• Patient using alcohol and\or drug and\or the other substance that might interfere with the patient participation
• Patient infected by HIV2
• Patient has severe hepatic insufficiency. (liver enzymes > 5N)
• Patient has the following laboratory values during selection
• Platelets < 40.000 cell / mm3
• Haemoglobin < 8 g / dl during the selection
• Neutrophils < 500 / mm3
• Patient has associated treatments which can have interactions with Raltegravir (Cf RCP Isentress ®)
• Patient should be considered by the investigator able to conform to the imperatives of the study procedures