Collection of Blood for Gene Expression/Genomic Studies in Individuals With Diabetes (Qatar)
2020年7月29日 更新者:Weill Medical College of Cornell University
This protocol is designed to gather a small amount of blood for extraction of DNA for the study of the genetic basis of diabetes.
The study population will include individuals with known diabetes, and controls without diabetes.
Investigators aim to understand the genetics of diabetes, and will use the cells and serum from this blood to perform genotyping and gene expression studies of individuals with diabetes and relevant controls.
研究概览
详细说明
This protocol is designed to collect a small amount of blood for extraction of DNA (genetic material) for the study of the genetic basis of diabetes.
The study population will include individuals with known diabetes and controls without diabetes.
Additionally, this protocol will recruit individuals from the following locations: the Qatar Diabetes Association, the governmental ministries of Qatar, and subjects who have participated in Dr. Bener's HMC protocol #231 entitled "A preliminary study of genetic pre-disposition to diabetic mellitus in the state of Qatar."
Individuals with diabetes may also be recruited from the Hamad Hospital outpatient adult diabetes clinics (there are eight diabetes clinics each week) and/or from the population of subjects who previously participated in Dr. Mushlin's IRB approved protocol #0608008703 entitled "Comparing the Clinical Management and Genetic Markers of Diabetes in Qatar to International Standards" at Hamad Medical Corporation or IRB approved protocol #0602008388 entitled "The Impact of Cardiac and Genetic Risk Factors on Acute Myocardial Infarction and Cerebrovascular Stroke in Qatar: A Case-Control Study".
In this protocol, researchers will survey medical records of patients with diabetes, in order to study the clinical characteristics of these individuals, and the researchers will collect blood to evaluate the genetic characteristics of individuals with diabetes.
The researchers will also collect blood samples of individuals without diabetes to serve as control.
研究类型
观察性的
注册 (实际的)
450
联系人和位置
本节提供了进行研究的人员的详细联系信息,以及有关进行该研究的地点的信息。
学习地点
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Doha、卡塔尔
- Hamad Medical Corporation
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参与标准
研究人员寻找符合特定描述的人,称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
18年 至 90年 (成人、年长者)
接受健康志愿者
是的
有资格学习的性别
全部
取样方法
非概率样本
研究人群
Diabetes group will be taken from (1)individuals visiting the Medicine Department at the Hamad Medical Corporation(HMC), Qatar for standard clinical care, (2)outpatient adult individuals seen at the HMCdiabetes clinics, (3)individuals who have participated in the following IRB protocol #s:0608008703, #0602008388 and HMC protocol #231, (4)ndividuals who attend clinics at the Qatar Diabetes Association (QDA), and (5)Individuals who work at the governmental ministries of Qatar.
Controls will be obtained from volunteers without a history of diabetes.
Family members of patients may be asked to participate in the study.
描述
Diabetes group
Inclusion criteria:
- Must provide informed consent
- Males and females, age 18 years and older
- Documented evidence of diabetes using at least one of the following: (1) blood tests consistent with Type-II diabetes; (2) oral glucose tolerance tests consistent with Type-II diabetes; (3) subject taking medication to treat Type-II diabetes.
Exclusion criteria:
- Individual refuses consent
- Pregnant females with gestational diabetes
- Type-I diabetes
Normal control group
Inclusion Criteria:
- Must provide informed consent
- Males or females ages 18 years and older
- Resolved gestational diabetes
Exclusion Criteria:
- Individual refuses consent.
- Individuals with history of diabetes.
学习计划
本节提供研究计划的详细信息,包括研究的设计方式和研究的衡量标准。
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
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Diabetes
Individuals with diabetes that fit eligibility criteria.
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Normal Control
Individuals without history of diabetes.
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合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
调查人员
- 研究主任:Ronald G Crystal, MD、Weill Cornell Medical College, NY and Qatar
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查,以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始
2009年6月1日
初级完成 (实际的)
2020年7月1日
研究完成 (实际的)
2020年7月1日
研究注册日期
首次提交
2010年7月28日
首先提交符合 QC 标准的
2010年7月28日
首次发布 (估计)
2010年7月30日
研究记录更新
最后更新发布 (实际的)
2020年7月31日
上次提交的符合 QC 标准的更新
2020年7月29日
最后验证
2020年7月1日
更多信息
此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.