The Impact of Early Embryos Incubation on Pregnancy Rate in IVF (IVF-2010)
研究概览
详细说明
It has been common practice to cryopreserve surplus embryos achieved during IVF treatment or in other situation that embryos are to be preserved for other situations such as suspected ovarian hyper stimulation syndrome, fertility preservation or patient request.
Embryos are usually frozen on day 2, 3 or day 5-6 at the Blastocyst stage. At the time that thawing is planned, patients' cycle is synchronized and prepared either with hormonal treatment or at the natural cycle.
Not all embryos will always survive the thawing and sometimes they will all degenerate.
Embryos that survive the thawing procedure are assessed and replaced on the day of the thaw or left overnight for better selection and will be replaced only if they continue to divide in vitro.
The advantage of embryo transfer on the day of thaw is that embryo exposure in culture is shortened and embryo selection will be occurring in the womb. On the other hand, overnight incubation may avoid transferring embryos that potentially are not able to divide and are biologically not viable.
Although both attitudes are practiced in different IVF centers, at present there are no prospective randomized studies that have been conducted to advise which intervention is better in terms of pregnancy rates.
The purpose of the present study is to assess which technique will result in better pregnancy rates.
研究类型
注册 (预期的)
联系人和位置
学习地点
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Haifa、以色列、34362
- 招聘中
- Carmel Medical Center
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接触：
- Martha Dirnfeld, MD
- 电话号码：9724 8250335
- 邮箱：dirnfeld_martha@clalit.org.il
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接触：
- Shirly Lahav-Baratz, D.Sc
- 电话号码：9724 8250118
- 邮箱：lahav_shirly@clalit.org.il
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首席研究员：
- Martha Dirnfeld, MD
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
660 IVF patients. patients who are candidates for embryo cryopreservation cycle will be offered to participate in the present prospective randomized study.
After detailed verbal and written explanation on the study protocol they will sign an informed consent and then randomized to 2 groups.
描述
Inclusion Criteria:
- IVF patient who have thawed embryo transfer and can read understand and sigh on informed consent
Exclusion Criteria:
- IVF patient who have thawed embryo transfer and can not read understand and sigh on informed consent/ also those whos embryos will not survive freezing- thawing
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
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Group A
Transfer at the day of embryo thawing
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Group B
Transfer of thawed embryos 24-72 hours post thawing
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Pregnancy as measured by blood test for beta hCG
大体时间：12 days following embryos transfer
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as the usual routine, the women come on day 12 or 13 following embryo transfer to pur IVF unit to get blood teat for beta hCG.
When the result show that the beta hCG is above 5 unit/liter we consider it as positive result and the patients is invited for additional blood test 2 days later/
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12 days following embryos transfer
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Delivery of baby
大体时间：9 mounth after embryos transfer
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We are routinely report to the Israeli ministry of health all the children who were born from our treatment.
In this study we will calculate the number of children per thawed embryo transfer.
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9 mounth after embryos transfer
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合作者和调查者
调查人员
- 首席研究员：Martha Dirnfeld, MD、Carmel Medical Center IVF Unit
出版物和有用的链接
一般刊物
- Lahav-Baratz S, Koifman M, Shiloh H, Ishai D, Wiener-Megnazi Z, Dirnfeld M. Analyzing factors affecting the success rate of frozen-thawed embryos. J Assist Reprod Genet. 2003 Nov;20(11):444-8. doi: 10.1023/b:jarg.0000006705.46147.a2.
- Lahav-Baratz S, Shiloh H, Koifman M, Kraiem Z, Wiener-Megnazi Z, Ishai D, Dirnfeld M. Early embryo-endometrial signaling modulates the regulation of matrix metalloproteinase-3. Fertil Steril. 2004 Oct;82 Suppl 3:1029-35. doi: 10.1016/j.fertnstert.2004.06.026.
研究记录日期
研究主要日期
学习开始
初级完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- CMC-10-0010-CTIL
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