The Impact of Real-time Functional Magnetic Resonance Imaging (fMRI) Feedback on Response to Nicotine Cues (RTSmoking)
The Impact of Real-time fMRI Feedback on Response to Nicotine Cues
研究概览
地位
条件
详细说明
There are three total visits for this study. Details of each visit are listed below.
Screening/Assessment Visit:
This evaluation will include interviews, questionnaires, computerized testing, urine drug screen, breath sample for carbon monoxide level and alcohol and physical examination. If accepted into this study, you will then be scheduled for a biofeedback and an imaging session. Both smokers and nonsmoking controls will go through the screening process.
Biofeedback Session:
You will be asked to participate in a biofeedback session scheduled for 60 minutes. You will be comfortably seated and a sensor to measure your temperature will be placed on a finger of your non-dominant hand. You will be asked to make changes in your skin temperature based on feedback from the monitoring system. Your responses to the biofeedback session will be compared to your responses to feedback in the scanner. Both smokers and nonsmoking controls will go through the biofeedback session.
Imaging Visit:
The imaging visit should last approximately 2 hours. You will also be asked to refrain from using alcohol and any street drugs for 24 hours and from using any marijuana for 3 days prior to the visit. If you smoke, you will be asked not to smoke for 2 hours prior to the scanning session. Evaluation will include an interview, questionnaires, and a breath carbon monoxide level. If you are a woman, a urine pregnancy test will be completed prior to the exam. If you smoke, you will be asked to complete questionnaires that focus on your craving and withdrawal symptoms for cigarettes. These questionnaires will take approximately 15 minutes to complete.
研究类型
注册 (预期的)
联系人和位置
学习地点
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South Carolina
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Charleston、South Carolina、美国、29425
- Medical University of South Carolina
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria (all participants):
- Age 18 - 60 right handed adults.
- General good health confirmed by history & physical.
- Able to read and understand questionnaires and informed consent.
- Participants must have a negative urine drug screen (UDS) and pregnancy test prior to imaging sessions.
- Female participants will use a reliable method of birth control throughout the study.
Additional Inclusion Criteria for non-smoking group:
1. Has used tobacco products no more than on experimental basis (none in past year).
Additional Inclusion Criteria for smoking group:
- Smokers must meet criteria for primary nicotine dependence confirmed by Fagerström Test for Nicotine Dependence (FTND) and smoking on average 10 cigarettes a day in the last 30 days prior to assessment.
- Smokers must be motivated to quit.
- Demonstrate subjective craving as measured by the Questionnaire of Smoking Urges (QSU)-B.
Exclusion Criteria:(all participants):
- Meets the Diagnostic and Statistical Manual (DSM)-IV criterion for lifetime or current substance dependence except for nicotine dependence.
- Any psychoactive substance abuse within the last 30 days as evidenced by subject report or urine drug screen.
- Use of other tobacco products.
- Current use of nicotine replacement therapy, bupropion, varenicline, or other smoking cessation treatment.
- Healthy volunteers must not have had more than experimental use of cigarettes.
- Meets DSM-IV criteria for current axis I disorders of major depression, panic disorder, obsessive compulsive disorder, post-traumatic stress syndrome, bipolar affective disorder, schizophrenia, or any other psychotic disorder or organic mental disorder. The rationale for excluding them is that symptoms from these disorders may affect dependent variables and complicate interpretation of the data.
- Current suicidal ideation with plan or homicidal ideation.
- Need for maintenance or acute treatment with any psychoactive medication including anti-seizure medications which could potentially interfere with fMRI.
- Clinically significant medical problems that would impair participation or limit ability to participate in scan.
- Sexually active females of child-bearing potential who are pregnant (by urine HCG), nursing, or who are not using a reliable form of birth control.
- Has current charges pending for a violent crime (not including Driving Under the Influence (DUI) related offenses).
- Persons with ferrous metal implants or pacemaker since fMRI will be used.
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
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Smokers
Nicotine addicted smokers, smoking an average of at least 10 cigarettes per day.
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Non-Smokers
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合作者和调查者
调查人员
- 首席研究员:Mark S George, M.D.、Medical University of South Carolina
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.