Influence of Breakfast Consumption on Chlorogenic Acid Metabolism in Humans
研究概览
研究类型
注册 (实际的)
阶段
- 不适用
联系人和位置
学习地点
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Kaiserslautern、德国、D-67663
- University of Kaiserslautern
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Healthy men and women
- Aged 20-44 years
- Caucasian origin
- Body mass index (BMI) 19-25 kg/m2
- Used to drinking coffee (similar to study coffee) on a daily basis
- Being able to tolerate a 48-hour coffee abstinence
- Normal oral glucose tolerance test
- Having signed the informed consent form
Exclusion Criteria:
- Taking medication or dietary supplements
- Smoking
- Performing a competitive sport
- Having metabolic disorders
- Long gut transit time (>24 h)
- Blood donor
- Irregularity in menstrual cycle (for women)
- Pregnancy (for women)
- Subject who cannot be expected to comply with the study procedures.
- Currently participating or having participated in another clinical trial during the last 4 weeks prior to the beginning of this study.
学习计划
研究是如何设计的？
设计细节
- 主要用途：基础科学
- 分配：随机化
- 介入模型：交叉作业
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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实验性的：Coffee, bread and honey
200 mL coffee + 2 bread rolls + honey
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Amounts of chlorogenic acids will be normalized to body weight (3.1 mg CA / kg BW). Coffee will be reconstituted in 200 mL hot water and consumed 3 times in a row (min 1-week interval), alone or with a breakfast:
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实验性的：Coffee, bread and peanut butter
200 mL coffee + 1 bread roll + peanut butter
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Amounts of chlorogenic acids will be normalized to body weight (3.1 mg CA / kg BW). Coffee will be reconstituted in 200 mL hot water and consumed 3 times in a row (min 1-week interval), alone or with a breakfast:
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实验性的：200 mL black coffee
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Amounts of chlorogenic acids will be normalized to body weight (3.1 mg CA / kg BW). Coffee will be reconstituted in 200 mL hot water and consumed 3 times in a row (min 1-week interval), alone or with a breakfast:
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研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
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Sum of plasma areas under the curve of coffee phenolics
大体时间：Measurements over 24h after coffee ingestion
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Measurements over 24h after coffee ingestion
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次要结果测量
结果测量 |
大体时间 |
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Plasma AUC, Cmax and Tmax of individually measured coffee chlorogenic and phenolic acids
大体时间：Measurements done over 24h after coffee ingestion
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Measurements done over 24h after coffee ingestion
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Urinary excretion of coffee chlorogenic and phenolic acids expressed as % ingested dose
大体时间：Measurements done over 24h after coffee ingestion
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Measurements done over 24h after coffee ingestion
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合作者和调查者
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- 11.12.NRC
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.