Influence of Breakfast Consumption on Chlorogenic Acid Metabolism in Humans

Data and knowledge gathered on bioavailability of coffee phenolics is becoming more and more important, hence underlying the importance of better understanding the fate of these potential health promoting antioxidants. However, some analytical barriers as well as some key aspects of metabolism still remain to be fully elucidated to get the full picture of coffee metabolism and bioavailability. One aspect addressed in the present study is the impact of food matrix in modulating absorption, plasma appearance and urinary excretion of coffee bioactives.

Study Overview

• Status: Completed
• Conditions: Healthy
• Intervention / Treatment: Other: Soluble Coffee

• Study Type: Interventional
• Enrollment (Actual): 14
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Germany
  • Kaiserslautern, Germany, D-67663
    • University of Kaiserslautern

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years to 44 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Healthy men and women
• Aged 20-44 years
• Caucasian origin
• Body mass index (BMI) 19-25 kg/m2
• Used to drinking coffee (similar to study coffee) on a daily basis
• Being able to tolerate a 48-hour coffee abstinence
• Normal oral glucose tolerance test
• Having signed the informed consent form

Exclusion Criteria:

• Taking medication or dietary supplements
• Smoking
• Performing a competitive sport
• Having metabolic disorders
• Long gut transit time (>24 h)
• Blood donor
• Irregularity in menstrual cycle (for women)
• Pregnancy (for women)
• Subject who cannot be expected to comply with the study procedures.
• Currently participating or having participated in another clinical trial during the last 4 weeks prior to the beginning of this study.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: None (Open Label)

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Coffee, bread and honey; 200 mL coffee + 2 bread rolls + honey	Other: Soluble Coffee; Amounts of chlorogenic acids will be normalized to body weight (3.1 mg CA / kg BW). Coffee will be reconstituted in 200 mL hot water and consumed 3 times in a row (min 1-week interval), alone or with a breakfast: 200 mL coffee or; 200 mL coffee + 2 bread rolls + honey; 200 mL coffee + 1 bread roll + peanut butter
Experimental: Coffee, bread and peanut butter; 200 mL coffee + 1 bread roll + peanut butter	Other: Soluble Coffee; Amounts of chlorogenic acids will be normalized to body weight (3.1 mg CA / kg BW). Coffee will be reconstituted in 200 mL hot water and consumed 3 times in a row (min 1-week interval), alone or with a breakfast: 200 mL coffee or; 200 mL coffee + 2 bread rolls + honey; 200 mL coffee + 1 bread roll + peanut butter
Experimental: 200 mL black coffee	Other: Soluble Coffee; Amounts of chlorogenic acids will be normalized to body weight (3.1 mg CA / kg BW). Coffee will be reconstituted in 200 mL hot water and consumed 3 times in a row (min 1-week interval), alone or with a breakfast: 200 mL coffee or; 200 mL coffee + 2 bread rolls + honey; 200 mL coffee + 1 bread roll + peanut butter

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Sum of plasma areas under the curve of coffee phenolics	Measurements over 24h after coffee ingestion

Secondary Outcome Measures

Outcome Measure	Time Frame
Plasma AUC, Cmax and Tmax of individually measured coffee chlorogenic and phenolic acids	Measurements done over 24h after coffee ingestion
Urinary excretion of coffee chlorogenic and phenolic acids expressed as % ingested dose	Measurements done over 24h after coffee ingestion

Collaborators and Investigators

• Sponsor: Société des Produits Nestlé (SPN)

Study record dates

Study Major Dates

• Study Start: September 1, 2011
• Primary Completion (Actual): December 1, 2012
• Study Completion (Actual): December 1, 2012

Study Registration Dates

• First Submitted: January 27, 2012
• First Submitted That Met QC Criteria: January 27, 2012
• First Posted (Estimate): February 1, 2012

Study Record Updates

• Last Update Posted (Estimate): June 5, 2013
• Last Update Submitted That Met QC Criteria: June 4, 2013
• Last Verified: June 1, 2013

More Information

Terms related to this study

• Other Study ID Numbers: 11.12.NRC