Glasgow Asthma and Allergy Study (GLAAS)
Cross Sectional Study to Evaluate and Associate Clinical and Laboratory Features of People With Allergic and Non-allergic Asthma
In the past, doctors separated people with asthma into two groups, those with "allergic asthma" (about 2/3rds of people) and those with "non-allergic asthma". These labels are not much used now as the treatments for all people with asthma don't depend on this classification. However, new treatments for asthma may become available and the classification may again become important. It could be useful for clinicians to know how to identify which patients are likely to benefit from particular treatments.
Additionally, some new blood tests are becoming available and some of these might help to categorise the type of asthma people have. What the study hopes to do is to identify patient features which make a diagnosis of "allergic asthma" more likely and to see which new blood tests are most likely to be helpful in confirming this diagnosis.
研究概览
研究类型
注册 (实际的)
联系人和位置
学习地点
-
-
Kent
-
Dartford、Kent、英国、DA1 5GA
- NSHI Ltd
-
-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Male and female patients aged 18 years old and over with a diagnosis of asthma and having received at least two prescriptions for any asthma medication in the last 12 months, who have signed an informed consent form prior to initiation of any study-related procedure
Exclusion Criteria:
- under 18 years
- current smokers
- unwilling or unable to give informed consent
- a clinical diagnosis of COPD
- a history of anaphylaxis (skin prick test)
- participated in any clinical study in the last 12 months
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
|---|
|
General asthma population
People with asthma, aged 18 years and over, non smoker, all severities of disease, regardless of treatment, broad inclusion and few exclusion criteria.
|
研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Serum periostin level
大体时间:1 day
|
This is a cross sectional study.
Participants will be assessed and tests conducted at a single visit
|
1 day
|
次要结果测量
结果测量 |
大体时间 |
|---|---|
|
skin prick test
大体时间:1 day
|
1 day
|
|
Serum total IgE
大体时间:1 day
|
1 day
|
|
Blood eosinophil count
大体时间:1 day
|
1 day
|
|
Blood neutrophil count
大体时间:1 day
|
1 day
|
|
Blood CD4 cells that are positive for CRTh2
大体时间:1 day
|
1 day
|
|
Blood eosinophils expressing CRTh2
大体时间:1 day
|
1 day
|
|
Spirometry
大体时间:1 day
|
1 day
|
合作者和调查者
调查人员
- 首席研究员:John A Haughney, MB ChB、NSHI Ltd
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.