Glasgow Asthma and Allergy Study (GLAAS)
Cross Sectional Study to Evaluate and Associate Clinical and Laboratory Features of People With Allergic and Non-allergic Asthma
In the past, doctors separated people with asthma into two groups, those with "allergic asthma" (about 2/3rds of people) and those with "non-allergic asthma". These labels are not much used now as the treatments for all people with asthma don't depend on this classification. However, new treatments for asthma may become available and the classification may again become important. It could be useful for clinicians to know how to identify which patients are likely to benefit from particular treatments.
Additionally, some new blood tests are becoming available and some of these might help to categorise the type of asthma people have. What the study hopes to do is to identify patient features which make a diagnosis of "allergic asthma" more likely and to see which new blood tests are most likely to be helpful in confirming this diagnosis.
Studieöversikt
Studietyp
Inskrivning (Faktisk)
Kontakter och platser
Studieorter
-
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Kent
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Dartford, Kent, Storbritannien, DA1 5GA
- NSHI Ltd
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-
Deltagandekriterier
Urvalskriterier
Åldrar som är berättigade till studier
Tar emot friska volontärer
Kön som är behöriga för studier
Testmetod
Studera befolkning
Beskrivning
Inclusion Criteria:
- Male and female patients aged 18 years old and over with a diagnosis of asthma and having received at least two prescriptions for any asthma medication in the last 12 months, who have signed an informed consent form prior to initiation of any study-related procedure
Exclusion Criteria:
- under 18 years
- current smokers
- unwilling or unable to give informed consent
- a clinical diagnosis of COPD
- a history of anaphylaxis (skin prick test)
- participated in any clinical study in the last 12 months
Studieplan
Hur är studien utformad?
Designdetaljer
Kohorter och interventioner
Grupp / Kohort |
|---|
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General asthma population
People with asthma, aged 18 years and over, non smoker, all severities of disease, regardless of treatment, broad inclusion and few exclusion criteria.
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Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
Serum periostin level
Tidsram: 1 day
|
This is a cross sectional study.
Participants will be assessed and tests conducted at a single visit
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1 day
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Sekundära resultatmått
Resultatmått |
Tidsram |
|---|---|
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skin prick test
Tidsram: 1 day
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1 day
|
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Serum total IgE
Tidsram: 1 day
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1 day
|
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Blood eosinophil count
Tidsram: 1 day
|
1 day
|
|
Blood neutrophil count
Tidsram: 1 day
|
1 day
|
|
Blood CD4 cells that are positive for CRTh2
Tidsram: 1 day
|
1 day
|
|
Blood eosinophils expressing CRTh2
Tidsram: 1 day
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1 day
|
|
Spirometry
Tidsram: 1 day
|
1 day
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Samarbetspartners och utredare
Samarbetspartners
Utredare
- Huvudutredare: John A Haughney, MB ChB, NSHI Ltd
Studieavstämningsdatum
Studera stora datum
Studiestart
Primärt slutförande (Faktisk)
Avslutad studie (Faktisk)
Studieregistreringsdatum
Först inskickad
Först inskickad som uppfyllde QC-kriterierna
Första postat (Uppskatta)
Uppdateringar av studier
Senaste uppdatering publicerad (Uppskatta)
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
Senast verifierad
Mer information
Termer relaterade till denna studie
Nyckelord
Ytterligare relevanta MeSH-villkor
Andra studie-ID-nummer
- 12/WS/0049
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