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Mother-caregivers of Children With Duchenne Muscular Dystrophy (DMDK)

2016年2月2日 更新者：Monica Levy Andersen

Profile of Mother-caregivers of Children With Duchenne Muscular Dystrophy

The incidence of Duchenne Muscular Dystrophy (DMD) is approximately 1 in 3.500 male newborns. During its progression there is loss of mobility, swallowing difficulties and a significant reduction in respiratory capacity. Due to the severity and consequences, is inevitable the need for a caregiver, that normally rely the mother.

研究概览

地位

完全的

条件

干预/治疗

详细说明

The Duchenne Muscular Dystrophy (DMD) is a neuromuscular disease characterized by genetic alteration, whose consequence is the progression of muscle degeneration. The mother-caregiver dedicates herself entirely to her son, putting aside the care of their physical and psychological health. The responsibility and workload to care for the child is high. Because of this extreme amount of work associated with other factors such as stress, this mothers-caregivers are more likely to develop hypertension, respiratory disease, susceptibility to infections, depression, anxiety, insomnia, impaired immune and cardiovascular problems. Moreover, they are more likely to develop sleep disorders, those who may cause a high health risk, since many sleep disorders are related to cardiovascular, respiratory, neurological and immune systems.

研究类型

介入性

注册 (实际的)

60

阶段

  • 不适用

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习地点

  • 巴西
      • São Paulo、巴西、04024001
        • University Federal of Sao Paulo

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

25年 至 65年 (成人、年长者)

接受健康志愿者

是的

有资格学习的性别

女性

描述

Inclusion Criteria:

  • Mothers-caregivers of children and adolescents with DMD
  • Mothers of children and adolescents without any neuromuscular disease and that does not have any chronic disease (bronchiolitis obliterates, cystic fibrosis, a genetic syndrome)

Exclusion Criteria:

  • Volunteers with low levels of education (voluntary functional illiterate) that prevents the questionnaires and understanding of the guidelines made
  • Working mothers of nocturnal period

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

  • 主要用途：放映
  • 分配：非随机化
  • 介入模型：并行分配
  • 屏蔽：单身的

武器和干预

参与者组/臂
干预/治疗
实验性的：sleep parameters
To assess the sleep parameters.
生物：sleep parameters
Since the mother-caregiver dedicates herself entirely to her son, we will performe overnight polysomnography to assess the sleep pattern.
其他：cardiovascular parameters
To assess the cardiovascular profile of control mothers and caregivers-mothers.
生物：Cardiovascular profile
To assess the health profile of caregivers-mothers are analyzed some markers that may indicate an impairment or damage to the health of each of the parameters
其他名称：
  • Homocysteine
  • Myoglobin
  • Cardiac troponin I
  • Creatine kinase (CK)
  • Creatine kinase MB (CKMB)
实验性的：imflammatory and immunological profile
To assess the inflammatory profile of caregivers-mothers and control mothers
生物：Inflammatory profile
To assess the health profile of caregivers-mothers are analyzed some markers that may indicate an impairment or damage to the health of each of the parameters
其他名称：
  • 瘦素
  • 前列腺素E2
  • 半胱氨酸
  • 白细胞介素2
  • C-reactive protein (PCR)
  • Immunoglobulin A (IgA)
  • Immunoglobulin G (IgG)
  • Immunoglobulin M (IgM)
  • Complement (C3)
  • Complement (C4)
  • Interleukin 6
  • Interleukin 10
  • Interleukin 1β
  • Interleukin 4
  • Interleukin 8
  • Interferon-gamma (IFN-γ)
  • Endothelin
  • Intercellular Adhesion Molecule 1 (ICAM)
  • Vascular cell adhesion protein 1 (VCAM)
  • Tumor necrosis factor (TNFα)
  • Adiponectin
  • Lymphocytes subpopulations (T e B)
实验性的：hormonal profile
To assess the hormonal profile of caregivers-mothers and control mothers.
生物：Hormonal profile
To assess the health profile of caregivers-mothers are analyzed some markers that may indicate an impairment or damage to the health of each of the parameters.
其他名称：
  • 皮质醇
  • 黄体酮
  • 雌二醇
  • 胰岛素
  • 维生素B12
  • Luteinizing hormone (LH)
  • Follicle-stimulating hormone (FSH)
  • Total Testosterone
  • Adrenocorticotropic hormone (ACTH)
实验性的：metabolic profile
To assess the health profile of caregivers-mothers and control mothers.
生物：Metabolic profile
To assess the health profile of caregivers-mothers are analyzed some markers that may indicate an impairment or damage to the health of each of the parameters
其他名称：
  • 葡萄糖
  • 肌酐
  • 尿素
  • Total cholesterol and fractions
  • Triglycerides
  • Uric acid
  • Sodium
  • Potassium
  • Hemogram
  • Erythrocyte sedimentation rate
  • Natriuretic Peptide B

研究衡量的是什么？

主要结果指标

结果测量
措施说明
大体时间
sleep patterns of the study population
大体时间：Baseline
Since the mother-caregiver dedicates herself entirely to her son, we will performe overnight polysomnography to assess the sleep pattern.
Baseline

次要结果测量

结果测量
措施说明
大体时间
Hormonal profile
大体时间：Baseline

To assess the health profile of caregivers-mothers are analyzed some markers that may indicate an impairment or damage to the health of each of the parameters:

Insulin Cortisol Luteinizing hormone (LH) Follicle-stimulating hormone (FSH) Total Testosterone Estradiol Progesterone Vitamin B12 Adrenocorticotropic hormone (ACTH)
Baseline
Inflammatory profile
大体时间：Baseline

To assess the health profile of caregivers-mothers are analyzed some markers that may indicate an impairment or damage to the health of each of the parameters:

C-reactive protein (PCR) Immunoglobulin A (IgA) Immunoglobulin G (IgG) Immunoglobulin M (IgM) Complement (C3) Complement (C4) Interleukin 6 Interleukin 10 Interleukin 1β Interleukin 2 Interleukin 4 Interleukin 8 Interferon-gamma (IFN-γ) Endothelin Prostaglandin E2 Intercellular Adhesion Molecule 1 (ICAM) Vascular cell adhesion protein 1 (VCAM) Tumor necrosis factor (TNFα) Adiponectin Leptin Cysteine Lymphocytes subpopulations (T e B)
Baseline
Cardiovascular profile
大体时间：Baseline

To assess the health profile of caregivers-mothers are analyzed some markers that may indicate an impairment or damage to the health of each of the parameters:

Homocysteine Myoglobin Cardiac troponin I Creatine kinase (CK) Creatine kinase MB (CKMB)
Baseline
Metabolic profile
大体时间：Baseline

To assess the health profile of caregivers-mothers are analyzed some markers that may indicate an impairment or damage to the health of each of the parameters:

Glucose Total cholesterol and fractions Triglycerides Uric acid Creatinine Urea Sodium Potassium Hemogram Erythrocyte sedimentation rate Natriuretic Peptide B
Baseline

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Monica Levy Andersen

出版物和有用的链接

负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。

一般刊物

有用的网址

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始

2013年8月1日

初级完成 (实际的)

2013年8月1日

研究完成 (实际的)

2014年7月1日

研究注册日期

首次提交

2013年8月8日

首先提交符合 QC 标准的

2013年8月9日

首次发布 (估计)

2013年8月13日

研究记录更新

最后更新发布 (估计)

2016年2月3日

上次提交的符合 QC 标准的更新

2016年2月2日

最后验证

2016年2月1日

更多信息

与本研究相关的术语

关键字

其他相关的 MeSH 术语

其他研究编号

  • DMDK

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