Effect of Sucrose on Liver Fat
Effect of Eucaloric High and Low Sucrose Diets on Liver Fat in Healthy Adult Men With Liver Fat Levels Below 5%
研究概览
详细说明
DESIGN Randomized, cross-over design with two 7-day dietary interventions separated by a 4 week wash-out period. Dietary intervention will be based on iso-energetic substitution of sucrose for starch in a weight-maintaining diet. The two experimental conditions are: high sucrose diet at 25% of total energy intake (this is approximately the 95th percentile for UK intake of non-milk extrinsic sugars (NMES)); and low sucrose diet at 10% of total energy intake. Otherwise the macronutrient balance in both conditions will be based on UK average habitual intake.
POPULATION 10 healthy males aged between 20 and 40 years, with a BMI between 20-25kg/m2, with normal liver fat levels (<5%) and fasting plasma glucose and no evidence of insulin resistance will be recruited. No pre-existing morbidity including cardiac, hepatic or renal disease, history of diabetes, hypertension or hyperlipidemia. Usual physical activity of subjects to range from sedentary to a maximum of meeting the UK minimum activity recommendations (30 min moderate exercise 5 d/week). Habitual alcohol intake of less than 2 units per day.
TREATMENT Pre-intervention: Participants will be asked to record habitual dietary intake by completion of a 7-day food diary and be asked to wear an accelerometer armband to assess physical activity before each intervention week. Resting energy expenditure will also be assessed by indirect calorimetry.
7 day dietary interventions: Participants will be resident at the clinical research facility at Hammersmith Hospital during each intervention week for 5 out of the 7 days and all food will be provided at the facility. At the weekends, participants will have to leave the unit but food will be provided for those two days so that the diet can be continued at home.
At the start and end of each 7 day intervention: Weight, height and waist circumference will be taken; percentage liver fat and total and regional body composition will be measured by MRI. Fasting and post prandial plasma glucose, insulin and lipids will be measured and blood pressure.
研究类型
注册 (实际的)
阶段
- 不适用
联系人和位置
学习地点
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London、英国
- NIHR/Wellcome Trust Imperial Clinical Research Facility
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
Healthy men aged between 20 and 40 years with BMI between 20-25 kg/m2 and with normal liver fat levels (<5%), normal fasting glucose (less than 5.5mmol/l) and HbA1C less than 5.7% will be eligible to volunteer.
Exclusion Criteria:
- Type 1 diabetes, Type 2 diabetes, hypertension or hyperlipidaemia
- Gained or lost ≥ 3kg weight in the past three months
- Use of medication likely to interfere with metabolism, appetite regulation, glucose homeostasis and hormonal balance
- Regular consumer of sugar sweetened beverages
- Any chronic illness
- Cardiovascular, hepatic or renal disease
- Excess alcohol intake (>2 units per day)
- Exceeding UK minimum activity recommendation (30min moderate exercise 5d/wk)
- Current smokers (smoked within last 6 months)
- Any gastrointestinal disorder e.g. Crohn's disease, coeliac disease or irritable bowel syndrome
- A history of drug or alcohol abuse in the last 2 years
- Pancreatitis
- Unable to have MRI (eg. metallic or magnetic implants, claustrophobia)
学习计划
研究是如何设计的?
设计细节
- 主要用途:基础科学
- 分配:随机化
- 介入模型:交叉作业
- 屏蔽:单身的
武器和干预
参与者组/臂 |
干预/治疗 |
---|---|
实验性的:High sucrose diet
High sucrose diet for 7 days
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实验性的:Low sucrose diet
Low sucrose diet for 7 days
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Percentage Change in Liver Fat
大体时间:7 days
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Liver fat was assessed by magnetic resonance spectrometry (MRS)
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7 days
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Changes in Fasting Triglyceride Levels
大体时间:Baseline and 7 days
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Triglyceride levels assessed from plasma in fasting state
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Baseline and 7 days
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合作者和调查者
调查人员
- 首席研究员:Gary Frost、Imperial College London
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
关键字
其他研究编号
- SucroseLiver
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)?
药物和器械信息、研究文件
研究美国 FDA 监管的药品
研究美国 FDA 监管的设备产品
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