Familial Cancer Registry and DNA Bank
Clinical cancer genetics is an emerging new field in medical oncology, and has been incorporated into routine oncology practice in many leading medical institutions in North America and Europe. Cancer genetics is the study of genetic factors contributing to carcinogenesis. In the last 5-10 years, genes responsible for various well-defined hereditary cancer syndromes have been cloned. These include the BRCAJ/2 genes in hereditary breast and ovarian cancer syndrome, the A4PC gene in Familial Adenomatous Polyposis, and the mismatch repair genes (hMLH1, hMSH2, hPMS1, hPMS2, hMSH6) in hereditary non-polyposis colorectal cancer (HNPCC). One of the goals of a clinical cancer genetics service is to identify families at risk for hereditary cancer syndromes, provide genetic counseling, and offer genetic testing when appropriate. The identification of causative genes in hereditary cancer syndromes together with the advent of genetic testing is starting to have an impact on clinical management. The ability to identify a gene mutation in a cancer family allows predictive testing, stratifying at-risk family members into carriers who will benefit from aggressive surveillance and/or preventive options, and non-carriers who may be spared unnecessary surveillance. Appropriate use of genetic testing will ultimately result in medical cost reduction.
The investigators hypothesize that the clinical characteristics and genetic factors contributing to hereditary cancer in the Singaporean Asian population are distinct from those described for Western patients.
研究概览
地位
条件
研究类型
注册 (预期的)
联系人和位置
学习地点
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Singapore、新加坡、119074
- 招聘中
- National University Hospital
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接触:
- Soo Chin Lee, MBBS, MRCP
- 电话号码:+65 6779 5555
- 邮箱:Soo_Chin_Lee@nuhs.edu.sg
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Any individual with very early onset cancer (eg diagnosed before age 40).
- Any family with three or more first- or second-degree relatives with the same cancer
- Any individual with two or more different primary cancers
- Any family that fulfils diagnostic criteria for known hereditary cancer syndromes
Exclusion Criteria:
Nil
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
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Cancer patients
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研究衡量的是什么?
主要结果指标
结果测量 |
大体时间 |
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Change in genetics testing method
大体时间:2 years
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2 years
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合作者和调查者
调查人员
- 首席研究员:Soo Chin Lee, MBBS, MRCP、National University Hospital, Singapore
出版物和有用的链接
一般刊物
- Giardiello FM, Brensinger JD, Petersen GM, Luce MC, Hylind LM, Bacon JA, Booker SV, Parker RD, Hamilton SR. The use and interpretation of commercial APC gene testing for familial adenomatous polyposis. N Engl J Med. 1997 Mar 20;336(12):823-7. doi: 10.1056/NEJM199703203361202.
- Petersen GM, Brensinger JD, Johnson KA, Giardiello FM. Genetic testing and counseling for hereditary forms of colorectal cancer. Cancer. 1999 Dec 1;86(11 Suppl):2540-50. doi: 10.1002/(sici)1097-0142(19991201)86:11+3.0.co;2-8.
研究记录日期
研究主要日期
学习开始
初级完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- 2000/00511
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