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Evaluation of Reactive Oxygen Metabolites in the Value of COPD

2014年11月19日更新者：Jie liu、Beijing Chao Yang Hospital

System Evaluation of Reactive Oxygen Metabolites in the Value of Chronic Obstructive Pulmonary Disease

This study through the long-term observation followed up for 2 years to find the change of the COPD patients blood ROMs, systematically evaluate the relationship between ROMs and the severity of COPD. Evaluate the differences of prognosis between the different oxidative stress level (according to the level of ROMs are divided into higher and normal phenotype). Explore the new oxidative stress evaluation index ROMs application value in COPD.

研究概览

地位

未知

条件

COPD(Chronic Obstructive Pulmonary Disease)

详细说明

Reactive oxygen metabolites (reactive oxygen metabolites, ROMs) test is a method by measuring the total reactive oxygen metabolites (ROMs) content in blood so as to evaluate the overall level of oxidative stress in the human body .Our previous studies have established the method of detecting ROMs which is suitable for fully automatic biochemical analyser.Our study through the long-term observation followed up for 2 years to find the change of the COPD patients blood ROMs, systematically evaluate the relationship between ROMs and the severity of COPD. Evaluate the differences of prognosis between the different oxidative stress level (according to the level of ROMs are divided into higher and normal phenotype). Explore the new oxidative stress evaluation index ROMs application value in COPD.

研究类型

观察性的

注册 (预期的)

320

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习地点

中国
- Beijing
  - Beijing、Beijing、中国、100020
    - 招聘中
    - Respiratory Institute;Beijing chaoyang hospital
    - 首席研究员：
      
      Jie Liu
    - 接触：
      
      Jie Liu, Master
      
      电话号码：18811225394
      
      邮箱：chaoyangliujie@163.com
    - 首席研究员：
      
      Xiaoning Bu, Doctor
    - 副研究员：
      
      Hong Zhang, Master
    - 副研究员：
      
      Xiaohong Chang
    - 副研究员：
      
      Baomei Wu
    - 副研究员：
      
      Jingyu Quan
    - 首席研究员：
      
      Huimin Gong
    - 首席研究员：
      
      Hongyan Pang

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

40年至 75年 (成人、年长者)

接受健康志愿者

是的

有资格学习的性别

全部

取样方法

非概率样本

研究人群

Chaoyang hospital clinic

描述

Inclusion Criteria:

Clinical diagnosis of COPD according to GOLD 2013

Exclusion Criteria:

A history of asthma or other chronic lung diseases Take Antioxidant therapy There are new or recurrent symptomatic myocardial ischemia, severe arrhythmia, cardiac insufficiency cerebrovascular disease Senile dementia or cognitive impairment cancer Severe liver and kidney and other viscera function insufficiency Language communication barriers Limb activity disorder The last 3 months participated in sports training

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

团体/队列数

队列和干预

团体/队列
Stability in patients with COPD Those patients diagnosed COPD according to the GOLD guideline and without acute exacerbation within one month.
AECOPD the diagnosis of an exacerbation relies exclusively on the clinical presentation of the patient complaining of an acute change of symptoms (baseline dyspnea, cough, and/or sputum production) that is beyond normal day-to-day variation.
Healthy persons without smoking The healthy people who do not smoke
Healthy persons with smoking Healthy persons who smoke

研究衡量的是什么？

主要结果指标

结果测量	措施说明	大体时间
The different levels of the ROMs among different groups 大体时间：3 years	Apply the analysis of variance to compare the different levels of ROMs among the four different groups	3 years

次要结果测量

结果测量	措施说明	大体时间
The differences of the ROMs among the different lung function levels in the stable stage of COPD group 大体时间：3 years	Apply the analysis of variance to compare the differences of the ROMs among the lung function levels in the stable stage of COPD group.	3 years
The relevance of the ROMs with the lung function levels in the stable stage of COPD group 大体时间：3 years	Apply Pearson correlation to compare relevance the of the ROMs with the lung function levels in the stable stage of COPD group.	3 years
The relevance of the ROMs with the score of mMRC in the stable stage of COPD group 大体时间：3 years	Apply Pearson correlation to compare relevance the of the ROMs with score of mMRC in the stable stage of COPD group.	3 years
The relevance of the ROMs with the score of CAT in the stable stage of COPD group 大体时间：3 years	Apply Pearson correlation to compare relevance the of the ROMs with score of CAT in the stable stage of COPD group.	3 years
The relevance of the ROMs with the numbers of exacerbation in the stable stage of COPD group 大体时间：3 years	Apply Pearson correlation to compare relevance the of the ROMs with numbers of exacerbation in the stable stage of COPD group.	3 years

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Beijing Chao Yang Hospital

调查人员

研究主任：Ting Yang, Doctor、Respiratory Institute, Beijing chaoyang hospital

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始

2014年10月1日

初级完成 (预期的)

2017年5月1日

研究完成 (预期的)

2017年7月1日

研究注册日期

首次提交

2014年11月17日

首先提交符合 QC 标准的

2014年11月19日

首次发布 (估计)

2014年11月21日

研究记录更新

最后更新发布 (估计)