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CT Indexes of Emphysema and Airways in Healthy Volunteers: Normal Values; Relations With Gender, Height and Weight

2015年11月19日 更新者：Erasme University Hospital
Various indexes have been proposed to quantify both pulmonary emphysema and airways disease on chest CT scans. It is unknown whether these indexes should be consider in absolute values or as compared to predicted normal values. The purposes of the present study is thus : a) to measure these indexes at CT in healthy volunteers; b) to investigate their relations with gender, height and weight.

研究概览

地位

完全的

条件

干预/治疗

详细说明

87 healthy volunteers performed consecutively a low-dose chest CT scan and pulmonary function tests:

  1. On chest CT scans, indexes reflecting pulmonary emphysema and airways measurements have been computed by using dedicated softwares. Each of our three readers performed two reading sessions.

    Relative area of lung parenchyma with attenuation value less than -960 Hounsfield Units; luminal area and wall thickness in third and fourth generations airways were recorded.

  2. Pulmonary function tests were performed: vital capacity, forced vital capacity , functional residual capacity, total lung capacity, residual volume, forced expiratory volume in one second, and diffusion lung capacity for carbon monoxide were recorded (either in absolute values and percentage of predicted values).

CT indexes were compared with gender, height and weight.

研究类型

观察性的

注册 (实际的)

87

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习地点

  • 比利时
      • Brussels、比利时、1070
        • Erasme University Hospital

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

18年 及以上 (成人、年长者)

接受健康志愿者

是的

有资格学习的性别

全部

取样方法

非概率样本

研究人群

Healthy Volunteers

描述

Inclusion Criteria:

  • Never smoked.
  • No respiratory infection in the 4 weeks before the begin of the study.
  • No history of pulmonary resection.
  • No active malignancy or malignancy of any organ system within the past 5 years.

Exclusion Criteria:

  • no exclusion criteria

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

队列和干预

团体/队列
干预/治疗
Healthy Volunteers

Inclusion criteria:

  1. Aged 18 or more.
  2. Never smoked.
  3. No respiratory infection in the 4 weeks before the begin of the study.
  4. No history of pulmonary resection.
  5. No active malignancy or malignancy of any organ system within the past 5 years.
辐射：Low-dose chest CT scans

Supine chest CT scan after full inspiration. Acquisition parameters: (Topogram 35 mA 120 kV 512 mm length)

35 quality ref mAs with care-dose ON 120 kV Pitch 1.4 Rotation time 0.33 s Acquired images 64 x 0.6 mm

研究衡量的是什么？

主要结果指标

结果测量
措施说明
大体时间
CT index - RA960 (%)
大体时间：4 hours
From acquired data, images were reconstructed using a soft algorithm. On these soft images, the relative area of lung parenchyma with attenuation value less than -960 Hounsfield Units was computed (expressed in %), as an index representative of pulmonary emphysema extent.
4 hours
CT index - LA3rd (mm2)
大体时间：4 hours
From acquired data, images were reconstructed using a high resolution algorithm. On these high-resolution images, the airway lumen was measured in third generations of airways (expressed in mm2).
4 hours
CT index - LA4th (mm2)
大体时间：4 hours
From acquired data, images were reconstructed using a high resolution algorithm. On these high-resolution images, the airway lumen was measured in fourth generations of airways (expressed in mm2).
4 hours
CT index - WT3rd (mm)
大体时间：4 hours
From acquired data, images were reconstructed using a high resolution algorithm. On these high-resolution images, the airway wall was measured in third generations of airways (expressed in mm).
4 hours
CT index - WT4th (mm)
大体时间：4 hours
From acquired data, images were reconstructed using a high resolution algorithm. On these high-resolution images, the airway wall was measured in fourth generations of airways (expressed in mm).
4 hours

次要结果测量

结果测量
措施说明
大体时间
Pulmonary function tests - VC (l)
大体时间：4 hours
Vital capacity was measured (expressed in l).
4 hours
Pulmonary function tests - FVC (l)
大体时间：4 hours
Forced vital capacity was measured (expressed in l).
4 hours
Pulmonary function tests - FRC (l)
大体时间：4 hours
Functional residual capacity capacity was measured (expressed in l).
4 hours
Pulmonary function tests - TLC (l)
大体时间：4 hours
Total lung capacity was measured (expressed in l).
4 hours
Pulmonary function tests - RV (l)
大体时间：4 hours
Residual volume was measured (expressed in l).
4 hours
Pulmonary function tests - FEV1 (l)
大体时间：4 hours
Forced expiratory volume in one second was measured (expressed in l).
4 hours
Pulmonary function tests - DLCO (ml/min/ mmHg)
大体时间：4 hours
Diffusion lung capacity for carbon monoxide was measured (expressed in ml/min/ mmHg)
4 hours

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Erasme University Hospital

出版物和有用的链接

负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。

一般刊物

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始

2010年10月1日

初级完成 (实际的)

2011年6月1日

研究完成 (实际的)

2011年6月1日

研究注册日期

首次提交

2015年10月30日

首先提交符合 QC 标准的

2015年11月19日

首次发布 (估计)

2015年11月23日

研究记录更新

最后更新发布 (估计)

2015年11月23日

上次提交的符合 QC 标准的更新

2015年11月19日

最后验证

2015年11月1日

更多信息

与本研究相关的术语

关键字

其他相关的 MeSH 术语

其他研究编号

  • P2010/175

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