Different Types of Fruits on Metabolic Function and Cognitive Performance (WBB2)

Inclusion Criteria:

• • Subject is male or female aged between 40 and 65 years of age

  • Subject has BMI between 18.5 and 34.9 kg/m2, (inclusive) at screening visit
  • Fasting blood sugar less than 126 mg/dL
  • Average Blood pressure less than 160/100 mmHg
  • Subject is willing to maintain a stable body weight and to follow his/her regular diet and physical activity patterns throughout the study period.
  • Subject is willing to refrain from vigorous physical activity and consumption of alcoholic and/or caffeinated beverages 24 h prior to each test day
  • Subject does not smoke or has abstained from smoking for at least 2 years
  • No clinical evidence of cardiovascular, metabolic, respiratory, renal, gastrointestinal or hepatic disease
  • Not taking any medications or dietary supplements that would interfere with outcomes of the study.

Exclusion Criteria:

• • Subject currently smokes or has smoked within the past 2 years

  • Subject works overnight i.e. the night shift
  • Subjects who have a significant sleep disorder, a traumatic brain injury, have a learning disability or attention deficit disorder or any psychiatric or neurological disturbances
  • Subject is color blind, has impaired cognitive performance on the flanker test (score <60 at screening) or has a vein access score <7
  • Men and women with known or suspected food intolerance, allergies or hypersensitivity to the study materials or closely related compounds
  • Men and women known to have/diagnosed with diabetes mellitus
  • Men and women with a fasting blood glucose concentration ≥126 mg/dL
  • Average blood pressure > 160/100 mmHg during screening visit
  • Men and women with documented vascular disease, e.g., heart failure, myocardial infarction, stroke, angina, related surgeries
  • Men and women with cancer other than non-melanoma skin cancer in previous 2 years
  • Men and women who are taking medication or dietary supplements that may interfere with the study procedures or the endpoints of the study (e.g. antioxidants, anti-inflammatory medications, antidepressant medications, oral and injectable hypoglycemic medications, GI medications, antibiotics, diuretics, adrenergic blockers etc.) Subjects may choose to go off dietary supplements (requires 30 days washout)
  • Men and women taking antibiotics within 5 days of study start
  • Men and women who have donated blood/plasma within 3 months of the screening visit and blood donors/participants for whom participation in this study will result in having donated more than 1500 milliliters of blood in the previous 12 months
  • Substance (alcohol or drug) abuse within the last 2 years
  • Excessive coffee and tea consumption (> 4 cups/day)
  • Unstable body weight fluctuations of >4.5kg (9.9lbs) in the past 4 weeks
  • Women who are known to be pregnant or who are intending to become pregnant over the course of the study and women who are lactating.
  • Men and women whom investigator is uncertain about subject's capability or willingness to comply with protocol requirements
  • Women who are taking unstable dose and brand of hormonal contraceptives and/or stable dose and brand less than 6 months.
  • Men and women who do excessive exercise regularly or are athlete