Cognitive, Behavioral and Aging Effects of Pain Medication in Alcohol Users (CAAP)

Inclusion Criteria:

• Age of 35 years old or above
• Mild to moderate pain
• alcohol consumption
• willingness to refrain from taking any sort of pain medication 24 hours prior to study visit as well as refraining from taking sedative-hypnotics, antihistamines, benzodiazepines, sleep aids, NSAIDs/opioid pain medications, alcohol, marijuana
• Cigarette smokers must be willing to refrain from smoking during the all day study visit

Exclusion Criteria:

• current regular use of an opioid or medications that involve the opioid receptor (naltrexone (vivitrol), buprenorphine (subutex), methadone (dolophine)
• abstains from alcohol
• unstable angina or CHF; cerebral vascular accident or recurrent TIAs in the prior 6 months, active cancer requiring current treatment, possible or probable dementia or mild cognitive impairment
• Diagnosis of schizophrenia or schizoaffective disorder, or anxiety disorder requiring regular medication
• History of recreational drug use in the past 1 year, excluding marijuana
• New or increased dose (within last 6 months) of CNS-active medications that may alter neurocognitive and/or psychomotor function: MAO inhibitors, neuroleptics, antidepressants, anticonvulsants, benzodiazepines, sleep aids
• Medications that may alter oxycodone metabolism: St. John's wort, Dilantin, tegretol, corticosteroids, rifampin
• Known hypersensitivity to oxycodone and other opioids;
• Pregnancy