Short- and Long-Term Renal Outcomes Following Lung Transplantation
2020年2月3日 更新者：Faeq Husain、University of Giessen
Short- and Long-Term Renal Outcomes Following Lung Transplantation- A Single-Centre Experience
Evaluation of acute kidney injury, renal recovery and development of chronic kidney disease in patients undergoing lung transplantation
研究概览
详细说明
It is well described that acute kidney injury and development of chronic kidney disease significantly impact short- and long-term survival after lung transplantation.
However, there is limited data about prevalence of kidney disease according to current KDIGO consensus guidelines.
It is the aim of this study to describe short- and long-term renal outcomes following lung transplantation.
Selected patients who underwent prospective pretransplant renal functional reserve testing with high oral protein load will be analyzed separately in respect to occurrence of acute kidney injury following lung transplantation and development of chronic kidney disease.
研究类型
观察性的
注册 (实际的)
120
联系人和位置
本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。
学习地点
-
-
Hessen
-
Giessen、Hessen、德国、35392
- University Clinic Giessen and Marburg - Campus Giessen
-
-
参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
18年 及以上 (成人、年长者)
接受健康志愿者
不
有资格学习的性别
全部
取样方法
非概率样本
研究人群
All patients undergoing lung transplantation at University Hospital Giessen between 2003 and 2016.
Subgroup of patients who underwent pretransplant renal functional reserve testing will be analyzed separately.
描述
For retrospective analysis for all patients undergoing lung transplantation:
Inclusion Criteria:
- Older than 18 years
Exclusion Criteria:
- Patients with eGFR <15ml/min/1.73m2 or with chronic dialysis treatment prior LTx
- Patients undergoing retransplantation and multiorgan transplantation
For prospective study involving patients with pretransplant renal functional reserve testing
Exclusion criteria:
- as above
- unable to perform renal functional reserve testing (e.g., due to critical illness)
- pre-existing acute kidney injury
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
|
Patients undergoing LTx
Retrospective analysis of clinical data
|
无干预
|
|
Patients with pretransplant renal functional reserve testing
Prospective analysis of clinical data
|
无干预
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Impact of acute kidney injury (AKI) after lung transplantation on long-term renal function decline.
大体时间：7 days
|
AKI defined by KDIGO consensus criteria
|
7 days
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Impact of sustained reversal versus non-recovery after AKI on long-term renal function decline after lung transplantation.
大体时间：3 years
|
AKI and CKD defined by KDIGO consensus criteria
|
3 years
|
|
Risk factors associated with development of AKI and CKD after lung transplantation
大体时间：3 years
|
AKI and CKD defined by KDIGO consensus criteria
|
3 years
|
|
Whether development of CKD is an independent risk factor for increased rejection rate and death after lung transplantation.
大体时间：3 years
|
CKD defined by KDIGO consensus criteria
|
3 years
|
|
Association between pretransplant renal functional reserve with acute kidney injury after after lung transplantation.
大体时间：7 days
|
AKI defined by KDIGO consensus criteria
|
7 days
|
|
Association between pretransplant renal functional reserve and renal function loss after lung transplantation.
大体时间：1 year
|
24h-creatinine clearance, estimated glomerular filtration rate
|
1 year
|
合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
调查人员
- 研究主任：Werner Seeger, MD、University Hospital Giessen and Marburg, Giessen, Department of Internal Medicine II, Division of Pulmonology, Nephrology and Critical Care Medicine
出版物和有用的链接
负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。
一般刊物
- Husain-Syed F, Ferrari F, Sharma A, Danesi TH, Bezerra P, Lopez-Giacoman S, Samoni S, de Cal M, Corradi V, Virzi GM, De Rosa S, Mucino Bermejo MJ, Estremadoyro C, Villa G, Zaragoza JJ, Caprara C, Brocca A, Birk HW, Walmrath HD, Seeger W, Nalesso F, Zanella M, Brendolan A, Giavarina D, Salvador L, Bellomo R, Rosner MH, Kellum JA, Ronco C. Preoperative Renal Functional Reserve Predicts Risk of Acute Kidney Injury After Cardiac Operation. Ann Thorac Surg. 2018 Apr;105(4):1094-1101. doi: 10.1016/j.athoracsur.2017.12.034. Epub 2018 Jan 31.
- Fidalgo P, Ahmed M, Meyer SR, Lien D, Weinkauf J, Cardoso FS, Jackson K, Bagshaw SM. Incidence and outcomes of acute kidney injury following orthotopic lung transplantation: a population-based cohort study. Nephrol Dial Transplant. 2014 Sep;29(9):1702-9. doi: 10.1093/ndt/gfu226. Epub 2014 Jun 23.
- Fidalgo P, Ahmed M, Meyer SR, Lien D, Weinkauf J, Kapasi A, Cardoso FS, Jackson K, Bagshaw SM. Association between transient acute kidney injury and morbidity and mortality after lung transplantation: a retrospective cohort study. J Crit Care. 2014 Dec;29(6):1028-34. doi: 10.1016/j.jcrc.2014.07.024. Epub 2014 Jul 31.
- Canales M, Youssef P, Spong R, Ishani A, Savik K, Hertz M, Ibrahim HN. Predictors of chronic kidney disease in long-term survivors of lung and heart-lung transplantation. Am J Transplant. 2006 Sep;6(9):2157-63. doi: 10.1111/j.1600-6143.2006.01458.x. Epub 2006 Jul 6.
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (实际的)
2017年3月22日
初级完成 (实际的)
2019年8月24日
研究完成 (实际的)
2019年8月24日
研究注册日期
首次提交
2017年2月4日
首先提交符合 QC 标准的
2017年2月4日
首次发布 (估计)
2017年2月8日
研究记录更新
最后更新发布 (实际的)
2020年2月5日
上次提交的符合 QC 标准的更新
2020年2月3日
最后验证
2020年2月1日
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.
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