Impact of Non Digestible Carbohydrate on Production of Phenolic Acids From Strawberry Juice
研究概览
详细说明
Polyphenol rich plant foods have been associated with several health benefits but their bioavailability is generally low. The majority of plant polyphenols are poorly absorbed in the small intestine and enter the colon where the colonic microbiota metabolise them to release a range of phenolic acids, which are now thought to be the main bioactive components related to the reduction in disease risk. Very little is known about the impact of other constituents of the diet on the metabolism and bacterial catabolism of these polyphenols. The colonic microbiota are key agents in the release of the bioactive molecules from polyphenols but also ferment non-digestible carbohydrates (NDC) such as dietary fibre to short chain fatty acids. It is likely that there are key interactions in the colonic bacteria metabolism of fibre and phenolics. We hypothesize that combination of polyphenolics and non-digestible carbohydrates (NDC) will increase the urinary output of bioactive phenolic acids.
This study will enable a better understanding of how to deliver combinations of ingredients and nutrients to achieve maximum nutritional value and health benefits.
研究类型
注册 (实际的)
阶段
- 不适用
联系人和位置
学习地点
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Lanarkshire
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Glasgow、Lanarkshire、英国、G31 2ER
- School of Medicine, Nursing and Dentistry, College of MVLS, University of Glasgow
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
Self-reported healthy adults
Exclusion Criteria:
Antibiotic use within the last 3 months, identified gastro-intestinal diseases, on prescribed medication other than the contraceptive pill, individuals who are pregnant or breastfeeding. Individuals who have been diagnosed as anaemic, as well as those who are allergic to any food, or paracetamol.
学习计划
研究是如何设计的？
设计细节
- 主要用途：基础科学
- 分配：随机化
- 介入模型：交叉作业
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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实验性的：Strawberry juice with inulin
One dose of 300 g of strawberry with 10 g of inulin will be given to subjects in the form of juice
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Mixture of polyphenols and non digestible carbohydrates
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实验性的：Strawberry juice
One dose of 300 g of strawberry juice will be given to subjects in the form of juice
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Source of Polyphenols
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实验性的：Inulin
One dose of 10 g of inulin will be given to subjects in the form of a drink
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不易消化碳水化合物的来源
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Phenolic acids bioavailability
大体时间：0-24 hrs
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Urine excretion of phenolic acids
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0-24 hrs
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Urolithin bioavailability
大体时间：0-24 hrs
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Urine excretion of urolithins
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0-24 hrs
|
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Glycaemic and appetite hormones measurements by ELISA
大体时间：0-8 hrs
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Plasma glucose, insulin and appetite hormone levels
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0-8 hrs
|
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Mouth to caecum transit time
大体时间：0-8 hrs
|
Breath hydrogen level measurements by Hydrogen monitor
|
0-8 hrs
|
|
Gastric emptying time
大体时间：0-6 hrs
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Plasma paracetamol levels by acetaminophen assay kits
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0-6 hrs
|
合作者和调查者
调查人员
- 首席研究员：Prof. Edwards、University of Glasgow
出版物和有用的链接
一般刊物
- Russell W, Duthie G. Plant secondary metabolites and gut health: the case for phenolic acids. Proc Nutr Soc. 2011 Aug;70(3):389-96. doi: 10.1017/S0029665111000152.
- Roowi S, Mullen W, Edwards CA, Crozier A. Yoghurt impacts on the excretion of phenolic acids derived from colonic breakdown of orange juice flavanones in humans. Mol Nutr Food Res. 2009 May;53 Suppl 1:S68-75. doi: 10.1002/mnfr.200800287.
- Henning SM, Wang P, Abgaryan N, Vicinanza R, de Oliveira DM, Zhang Y, Lee RP, Carpenter CL, Aronson WJ, Heber D. Phenolic acid concentrations in plasma and urine from men consuming green or black tea and potential chemopreventive properties for colon cancer. Mol Nutr Food Res. 2013 Mar;57(3):483-93. doi: 10.1002/mnfr.201200646. Epub 2013 Jan 14.
- Czank C, Cassidy A, Zhang Q, Morrison DJ, Preston T, Kroon PA, Botting NP, Kay CD. Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a (13)C-tracer study. Am J Clin Nutr. 2013 May;97(5):995-1003. doi: 10.3945/ajcn.112.049247.
- Morrison DJ, O'Hara JP, King RF, Preston T. Quantitation of plasma 13C-galactose and 13C-glucose during exercise by liquid chromatography/isotope ratio mass spectrometry. Rapid Commun Mass Spectrom. 2011 Sep 15;25(17):2484-8. doi: 10.1002/rcm.5139.
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- BB/MO27724/1-1
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