Cystic Fibrosis and Cognitive Function
Effects of Cystic Fibrosis and Cystic Fibrosis Related Diabetes on Brain Structure and Cognitive Function
研究概览
地位
条件
详细说明
A growing body of evidence suggests that hyperglycemia in type 1 and type 2 diabetes is associated with alterations in brain structure and cognitive impairment. People with cystic fibrosis related diabetes (CRFD) are exposed to hyperglycemia as seen in other forms of diabetes, and cystic fibrosis is also associated with chronic systemic inflammation. Both hyperglycemia and chronic inflammation have been postulated to affect brain structure and function. Cystic fibrosis trans-membrane conductance regulator (CFTR). protein is widely expressed in the neurons of the brain including in the hippocampus The hippocampus plays an essential role in learning and memory processing and is thought to be particularly vulnerable to effects of metabolic stressors. The expression of CFTR in neurons has several potential implications for central nervous system function, including cognition.
The long-term goal of this project is to examine the effects of cystic fibrosis (CF) and cystic fibrosis related diabetes (CFRD) on brain structure and function.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Minnesota
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Minneapolis、Minnesota、美国、55455
- Clinical and Translational Science Institute and Center for Magnetic Resonance Research, University of Minnesota
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
patients with Cystic fibrosis
Exclusion Criteria:
- History of stroke
- History of epilepsy
- History of neurosurgical procedures
- Past or current history of severe psychiatric illness
- Pass or current history of alcohol or substance abuse
- Presence of metallic substances in body or inability to remove before imaging procedure
- History of claustrophobia or known inability to tolerate MRI
- Current pregnancy
- Inability to consent
学习计划
研究是如何设计的?
设计细节
- 观测模型:病例对照
- 时间观点:预期
队列和干预
团体/队列 |
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Cystic Fibrosis
Subjects with cystic fibrosis
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controls
matched healthy controls
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
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MRI outcome
大体时间:baseline
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Measure the differences in the microstructure (fractional anisotropy) of hippocampus, comparing subjects with cystic fibrosis and healthy controls
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baseline
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
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Cognitive function
大体时间:baseline
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Compare performance on neurocognitive function testing in subjects with cystic fibrosis and healthy controls.
Multiple cognitive domains will be examined including intellectual function, processing speed.
attention and memory.
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baseline
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合作者和调查者
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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