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Comparison of Triple Antibiotic Paste With Combination of Chitosan and Calcium Hydroxide as a Root Canal Disinfectant

2020年3月21日 更新者：Soumya Shetty、Dr. D. Y. Patil Dental College & Hospital

Clinical and Radiographic Comparative Evaluation of Healing of Periapical Lesion Using Triple Antibiotic Paste With Combination of Chitosan and Calcium Hydroxide When Used as a Root Canal Disinfectant- An In Vivo Study

Investigators observed the clinical and radiographic healing of periapical lesion using Chitosan mixed with calcium hydroxide and compared it with triple antibiotic paste when used as intracanal medicament in 3months, 6 months and 12 months.

研究概览

地位

未知

条件

干预/治疗

详细说明

Aim: To evaluate and compare the healing of periapical lesions using chitosan mixed with calcium hydroxide or Triple Antibiotic Paste at 3,6 and 12 months.

Methodology:

20 adult patients having periapical lesions in single rooted teeth were selected in this study after being assessed using the PAI index. Patients were randomly assigned to: Group - I (n=10) Chitosan with Ca (OH)2 and Group -II (n=10) Triple Antibiotic paste (TAP)

After access opening and cleaning and shaping were done in the first visit, the pertinent intracanal medicaments were placed depending on the patient group. After 4 weeks, on the second visit, the medicament was removed andobturation was done in the asymptomatic teeth. Both clinical and radiographic endodontic evaluation was done at 0, 3, 6 and 12months using the same parameters.

Radiographic evaluation was done using the PAI Index and was compared at 0, 3, 6, and 12 months after treatment, Z Test.

研究类型

介入性

注册 (预期的)

40

阶段

  • 阶段2
  • 第三阶段

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习地点

  • 印度
    • Maharashtra
      • Pune、Maharashtra、印度、411 018
        • 招聘中
        • Dr DY Patil Dental College And Hospital (DPU)
        • 接触：
        • 接触：
        • 首席研究员：
          • soumya S shetty, MDS
        • 副研究员：
          • anita B tandale, MDS
        • 副研究员：
          • piyush D oswal, MDS

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

18年 至 40年 (成人)

接受健康志愿者

是的

有资格学习的性别

全部

描述

Inclusion Criteria:

  • Patients aged between 18 and 40 years Periapical lesion (not more than 5mm) radiographically.on single rooted teeth
  • Roots with closed apex.
  • Systemically healthy patients.

Exclusion Criteria:All patients who respond positive to allergic patch test [triple antibiotic paste] and drugs.

  • Teeth with previous endodontic therapy performed.
  • Patients with a history of any systemic diseases.
  • Pregnant and lactating women.
  • Tooth associated with vertical root fracture and coronal perforation.
  • Tooth affected with calcific degeneration.
  • Presence of external or internal root resorption.
  • Blunderbuss apex.

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

  • 主要用途：治疗
  • 分配：随机化
  • 介入模型：并行分配
  • 屏蔽：双倍的

武器和干预

参与者组/臂
干预/治疗
实验性的：Chitosan calcium hyroxide paste
after the access preparation and cleaning and shaping, chitosan calcium hydroxide paste will be placed in the canal and kept for 4 weeks.
药品：root canal treatment and intracanal medicament
after the access preparation and cleaning and shaping was done in 1st appointment using k files,"Mani" and protapers,"Dentsply" then in, chitosan calcium hydroxide paste," or ciprofloxacin metronidazole minocycline paste placed in the canal and kept for 4 weeks.
其他名称：
  • intra-oral periapical radiaograph,"kodak"
有源比较器：triple antibiotic paste
after the access preparation and cleaning and shaping, ciprofloxacin metronidazole minocycline paste will be :placed in the canal and kept for 4 weeks.
药品：root canal treatment and intracanal medicament
after the access preparation and cleaning and shaping was done in 1st appointment using k files,"Mani" and protapers,"Dentsply" then in, chitosan calcium hydroxide paste," or ciprofloxacin metronidazole minocycline paste placed in the canal and kept for 4 weeks.
其他名称：
  • intra-oral periapical radiaograph,"kodak"

研究衡量的是什么？

主要结果指标

结果测量
措施说明
大体时间
healing of periapical lesion
大体时间：change in PAI index from baseline to 3 months, baseline to 6 months and baseline to 12 months

the periapical status will be assessed by using the periapical index [PAI] using radiographs and scoring was done according to following scoring index as

  1. Normal periapical structures
  2. Small changes in bone structure
  3. Changes in bone structure with some mineral loss
  4. Periodontitis with well-defined radiolucent area
  5. Severe periodontitis with exacerbating features
change in PAI index from baseline to 3 months, baseline to 6 months and baseline to 12 months

次要结果测量

结果测量
措施说明
大体时间
patient pain perception
大体时间：3months, 6months and 12 months
pain will be assessed using visual analogue (VAS )scale along with any swelling following scale of -10 with 0 score depicts no pain and score 10 depicts severe pain
3months, 6months and 12 months

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Dr. D. Y. Patil Dental College & Hospital

调查人员

  • 研究主任：Piyush D Oswal, MDS、Dr. D Y Patil Dental College, Pimpri, Pune

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (实际的)

2018年12月3日

初级完成 (预期的)

2020年4月23日

研究完成 (预期的)

2020年8月4日

研究注册日期

首次提交

2020年3月18日

首先提交符合 QC 标准的

2020年3月21日

首次发布 (实际的)

2020年3月24日

研究记录更新

最后更新发布 (实际的)

2020年3月24日

上次提交的符合 QC 标准的更新

2020年3月21日

最后验证

2020年3月1日

更多信息

与本研究相关的术语

其他相关的 MeSH 术语

其他研究编号

  • DYPV/EC/55/16

药物和器械信息、研究文件

研究美国 FDA 监管的药品

不

研究美国 FDA 监管的设备产品

不

在美国制造并从美国出口的产品

不

此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.

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