Influence of Obstructive Sleep Apnea on the Severity of Coronary Artery Disease
The Prevalence and Influence of Obstructive Sleep Apnea in Coronary Artery Disease in Modern Age: Findings in A Large Cohort Study
研究概览
地位
条件
详细说明
Before initiating the study, all potential subjects were invited to attend an educational program that explained the purpose and methodology of this study. After getting informed consent from patients, demographic data including age, sex, medical history (including comorbidities and risk factors), current medicine, lifestyle habits, height (cm), and weight (kg) were recorded, and body mass index (BMI) was calculated as weight divided by height squared (kilograms per square meter, kg/m2). The included subjects need to perform transthoracic echocardiography or provide an echocardiographic examination within one month. CAD diagnosis was determined based on the results of the coronary angiography, using stenosis 50% cutoffs considered have coronary diseases or not.
Consecutive patients of both sexes with coronary angiography from outpatient or inpatient departments of Fuwai Hospital were recruited into the study. The inclusion criteria were Chinese, aged 35 to 75 years with CAD verified by coronary angiography, and able to give informed written consent. The subjects were excluded if they had New York Heart Association Class III-IV degree with ejection fraction < 45%, severe pulmonary disease, significant psychiatric disease, or history of pharyngeal surgery for OSA or current use of CPAP treatment for OSA. They were also excluded if they declined to participate or were unable to provide informed consent.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Beijing、中国、100037
- Center of pulmonary vascular disease, Fuwai hospital
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- aged 35 to 75 years with CAD
- CAD was verified by coronary angiography
Exclusion Criteria:
- Patients had New York Heart Association Class III-IV degree with ejection fraction < 45%
- Severe pulmonary disease
- Significant psychiatric disease
- History of pharyngeal surgery for OSA or current use of CPAP treatment for OSA
- Subjects declined to participate or were unable to provide informed consent.
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
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CAD with OSA
coronary artery disease with Obstructive sleep apnea
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CAD without OSA
coronary artery disease without Obstructive sleep apnea
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Association of apnea-hypopnea index (AHI) between obstructive sleep apnea and severity of coronary artery disease
大体时间:12 months
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The apnea-hypopnea index (AHI) was calculated as the total number of apneas and hypopneas occurring per hour of sleep.
And the severity of coronary artery disease was determined by Coronary angiography.
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12 months
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
---|---|---|
The Prevalence of Obstructive Sleep Apnea in Coronary Artery Disease in China
大体时间:12 months
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The number of patients with Obstructive Sleep Apnea in Coronary Artery Disease in China
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12 months
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合作者和调查者
调查人员
- 学习椅:Zhihong Liu, M.D、Fuwai Hospital
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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