Addition of MgSO4 or Dexamethasone to Bupivacaine on the Prolongation of Ultrasound-guided Quadratus Lumboram Block
A Comparative Study Between the Effect of Addition of MgSO4 or Dexamethasone to Bupivacaine on the Prolongation of Ultrasound-guided Quadratus Lumboram Block
The goal of postoperative pain management is the provision of comfort, early mobilization and improved respiratory function without causing inadequate sedation and respiratory compromise, which can be achieved through using regional anethesia.
This study aimed to assess the analgesic effect of adding dexamethasone or magnesium sulphate with bupivacaine in ultrasound-guided QLB to prolong its duration in patients undergoing open abdominal surgeries in the early postoperative period regarding pain relief After approval of the ethical committees in Ain Shams University Hospitals, patients undergoing open abdominal surgeries were included in the study, and were divided into three groups (n=22; each); group M, D and group C. In Group A, patients (n=22) received 20 ml bupivacaine 0.25% plus 5 ml of 10% MgSO. In group B, patients (n=22) received 20 ml bupivacaine 0.25% plus 8 mg dexamethasone (2 ml) plus 3 ml 0.9% NaCl. In group C (control), patients (n=22) received 20 ml bupivacaine plus 5 ml 0.9% NaCl.
研究概览
研究类型
注册 (实际的)
阶段
- 不适用
联系人和位置
学习地点
-
-
-
Cairo、埃及
- Ain-Shams University
-
-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- American Society of Anesthesiologists (ASA) physical status I or II
- aged 18 to 65 years
- body weight ≥ 60 kg and ≤ 90 kg
- scheduled for open abdominal surgeries
Exclusion Criteria:
- Patients' refusal to participate in the study
- history of allergy to the medications used in the study
- hepatic disease
- renal disease
- known neurologic disorders
- psychiatric disorder
- chronic treatment with calcium channel blockers
- hyper-magnesemia
- coagulopathy
- anatomical abnormalities
- hemodynamic instability
- local infection
- suspected intra- abdominal sepsis
学习计划
研究是如何设计的？
设计细节
- 主要用途：预防
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：双倍的
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
有源比较器：Bupivacaine Magnesium sulphate group
Patients received QL block with 20 ml of 0.25% bupivacaine (2, 4)plus 5 ml of 10% MgSO4.
|
Patients received QL block with 20 ml of 0.25% bupivacaine (2, 4)plus 5 ml of 10% MgSO4.
|
|
有源比较器：Bupivacaine Dexamethasone group
Patients received QL block with 20 ml of 0.25% bupivacaine (2,4)plus 2 ml of 8 mg dexamethasone plus 3 ml of 0.9% NS.
|
Patients received QL block with 20 ml of 0.25% bupivacaine (2,4)plus 2 ml of 8 mg dexamethasone plus 3 ml of 0.9% NS.
|
|
有源比较器：bupivacaine saline group
Patients received QL block with 20 ml of 0.25% bupivacaine (2,4)plus 5 ml of 0.9% NS.
|
Patients received QL block with 20 ml of 0.25% bupivacaine (2,4)plus 5 ml of 0.9% NS.
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Duration of post-operative analgesia
大体时间：24hours
|
Time from completion of the block to the first request of rescue analgesia.
|
24hours
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Mean arterial blood pressure
大体时间：24 hours
|
Measured before induction of anesthesia (base line), upon arrival to the PACU, after 30 and 60 min.
If hypotension (MBP < 20% of the base line value) occurred, 3 mg increments of ephedrine repeated every 5 min if required was given.
MBP was then recorded at 2, 6, 12 and 24 post-operative hours.
|
24 hours
|
|
Heart rate
大体时间：24 hours
|
Recorded before induction of anesthesia (base line),upon arrival to the PACU, after 30 and 60 min.
If bradycardia (HR <50 bpm) occurred, 0.5 mg atropine was given.
HR was then recorded at 2, 6, 12 and 24 post-operative hours.
|
24 hours
|
|
The severity of post-operative pain at rest
大体时间：24 hours
|
By using the Visual Analogue Scale (VAS); from 0= no pain, to 10=worst imaginable pain.
Assessed upon arrival to the PACU, after 30 and 60 min.
The VAS was then recorded at 2, 4, 6, 8, 12 and 24 post-operative hours.
|
24 hours
|
|
The severity of post-operative pain with movement (bilateral knee flexion)
大体时间：24 hours
|
By using the Visual Analogue Scale (VAS); from 0= no pain, to 10=worst imaginable pain.
Assessed at 2, 4, 6, 8, 12 and 24 post-operative hours
|
24 hours
|
|
Number of patients requiring post-operative rescue analgesia
大体时间：24 hours
|
Number of patients requiring pethidine in the 24 hours post-operative period
|
24 hours
|
|
Total dose of pethidine given
大体时间：24 hours
|
The cumulative total pethidine doses given to each patient in the 24 hours post-operative period.
|
24 hours
|
|
Occurrence of nausea and/or vomiting:
大体时间：24 hours
|
Number of patients who develop nausea and/or vomitting
|
24 hours
|
|
Time to first ambulation
大体时间：24 hours
|
The time to the start of movement by each patient in the 24 hours post-operative period
|
24 hours
|
|
The analgesic satisfaction at 24 post-operative hours
大体时间：24 hours
|
Patients were asked to report their satisfaction with the pain management; assessed as, 1 = poor, 2 = fair, 3 = good, and 4 = excellent.
|
24 hours
|
|
Inadvertent femoral nerve block
大体时间：24 hours
|
number of patients who develop lower limb weakness
|
24 hours
|
|
Local Anesthetic Systemic Toxicity (LAST):
大体时间：24 hours
|
As any regional anesthesia technique with local anesthetic is associated with potential systemic absorption of local anesthetics.
|
24 hours
|
合作者和调查者
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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