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Bone Cancer Surgery Prospective Database

2026年6月24日更新者：Second Affiliated Hospital, School of Medicine, Zhejiang University

Bone Cancer Surgery Prospective Database on Perioperative Characteristics and Postoperative Complications

According to the Global Burden of Disease Report, the number of cancer patients worldwide is increasing year by year. In 2023, there were a total of 18.5 million newly confirmed cases of malignant tumors worldwide, and it is expected to grow to 30.5 million cases by 2050. Among them, the number of new cases of malignant tumors of bone and articular cartilage increased by 86.4% from 1990 to 2023. Meanwhile, bone is a particularly common site for tumor metastasis, and almost half of cancer patients are at risk of developing bone metastasis. Surgical resection is the main treatment method for both primary and secondary bone cancer. For patients with bone cancer, the main goal of surgical treatment is to maintain the patient's function and mobility by relieving pain, preventing impending fractures and/or nerve compression, or stabilizing pathological fractures. Surgery for bone cancer often requires extensive exploration, osteotomy, and prosthetic reconstruction, resulting in significant surgical trauma. The incidence of postoperative complications remains high. The occurrence of postoperative complications can increase patient pain, prolong hospitalization time, increase medical costs, and even endanger life. Therefore, reduction of complications and optimizing perioperative management are key issues that urgently need to be addressed in clinical practice.

研究概览

地位

尚未招聘

条件

Bone Cancer Surgery

干预/治疗

程序：Bone cancer surgery

详细说明

At present, there is a lack of high-quality evidence-based measures for perioperative management of bone cancer. Previous studies have mainly been retrospective, with common issues such as missing variables, small sample sizes, and single disease types, making it difficult to systematically reveal perioperative pathophysiological patterns and provide reliable evidence for clinical management. Therefore, high-quality prospective studies are urgently needed.

Therefore, this study intends to conduct a prospective cohort study of patients undergoing surgery for bone cancer, establish a perioperative database, clarify the incidence of complications, explore the factors related to perioperative complications, and provide evidence-based support for improving perioperative management and patient prognosis.

研究类型

观察性的

注册 (估计的)

400

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习地点

中国
- Zhejiang
  - Hangzhou、Zhejiang、中国、310000
    - The Second Affiliated Hospital of Zhejiang University anesthesiology department
    - 首席研究员：
      
      Min Yan, Doctor
    - 接触：
      
      Min Yan, Doctor
      
      电话号码：+86 15888210247
      
      邮箱：zryanmin@zju.edu.cn

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

孩子
成人
年长者

接受健康志愿者

不

取样方法

非概率样本

研究人群

patients undergoing elective bone cancer resection surgery

描述

Inclusion Criteria:

Clinical diagnosis of bone cancer
Scheduled to undergo elective bone cancer resection surgery

Exclusion Criteria:

Unable to comply with follow-up
declined participation in the study

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

研究衡量的是什么？

主要结果指标

结果测量	措施说明	大体时间
Complication 大体时间：hospital discharge, an average of 10 days	This includes embolic events, pulmonary complication, wound complication, acute kidney injury, death. Diagnose according to radiologic examination, sign and symptom	hospital discharge, an average of 10 days

次要结果测量

结果测量	措施说明	大体时间
6个月死亡率大体时间：6个月		6个月
The rate of perioperative transfusion of allogeneic blood products 大体时间：hospital discharge, an average of 10 days	This includes blood products such as plasma and platelets, erythrocytes	hospital discharge, an average of 10 days
The coagulation function tests during the perioperative period 大体时间：hospital discharge, an average of 10 days	This includes thromboelastography result	hospital discharge, an average of 10 days
Wound drainage volume 大体时间：hospital discharge, an average of 10 days	Accumulated postoperative wound drainage volume	hospital discharge, an average of 10 days
Hemoglobin levels 大体时间：hospital discharge, an average of 10 days	Hemoglobin levels during hospitalIzation	hospital discharge, an average of 10 days
1-year mortality 大体时间：1 year		1 year
2-year mortality 大体时间：2 years		2 years
3-year mortality 大体时间：3 years		3 years

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Second Affiliated Hospital, School of Medicine, Zhejiang University

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (估计的)

2026年7月1日

初级完成 (估计的)

2026年7月1日

研究完成 (估计的)

2028年7月1日

研究注册日期

首次提交

2026年6月22日

首先提交符合 QC 标准的

2026年6月22日

首次发布 (实际的)

2026年6月25日

研究记录更新

最后更新发布 (实际的)

2026年6月29日

上次提交的符合 QC 标准的更新

2026年6月24日

最后验证

2026年6月1日

Bone Cancer Surgery Prospective Database