Bone Cancer Surgery Prospective Database

Bone Cancer Surgery Prospective Database on Perioperative Characteristics and Postoperative Complications

According to the Global Burden of Disease Report, the number of cancer patients worldwide is increasing year by year. In 2023, there were a total of 18.5 million newly confirmed cases of malignant tumors worldwide, and it is expected to grow to 30.5 million cases by 2050. Among them, the number of new cases of malignant tumors of bone and articular cartilage increased by 86.4% from 1990 to 2023. Meanwhile, bone is a particularly common site for tumor metastasis, and almost half of cancer patients are at risk of developing bone metastasis. Surgical resection is the main treatment method for both primary and secondary bone cancer. For patients with bone cancer, the main goal of surgical treatment is to maintain the patient's function and mobility by relieving pain, preventing impending fractures and/or nerve compression, or stabilizing pathological fractures. Surgery for bone cancer often requires extensive exploration, osteotomy, and prosthetic reconstruction, resulting in significant surgical trauma. The incidence of postoperative complications remains high. The occurrence of postoperative complications can increase patient pain, prolong hospitalization time, increase medical costs, and even endanger life. Therefore, reduction of complications and optimizing perioperative management are key issues that urgently need to be addressed in clinical practice.

Study Overview

• Status: Not yet recruiting
• Conditions: Bone Cancer Surgery
• Intervention / Treatment: Procedure: Bone cancer surgery

Detailed Description

At present, there is a lack of high-quality evidence-based measures for perioperative management of bone cancer. Previous studies have mainly been retrospective, with common issues such as missing variables, small sample sizes, and single disease types, making it difficult to systematically reveal perioperative pathophysiological patterns and provide reliable evidence for clinical management. Therefore, high-quality prospective studies are urgently needed.

Therefore, this study intends to conduct a prospective cohort study of patients undergoing surgery for bone cancer, establish a perioperative database, clarify the incidence of complications, explore the factors related to perioperative complications, and provide evidence-based support for improving perioperative management and patient prognosis.

• Study Type: Observational
• Enrollment (Estimated): 400

Contacts and Locations

Study Locations

• China
  • Zhejiang
    • Hangzhou, Zhejiang, China, 310000
      • The Second Affiliated Hospital of Zhejiang University anesthesiology department
      • Principal Investigator: Min Yan, Doctor
      • Contact: Min Yan, Doctor; Phone Number: +86 15888210247; Email: zryanmin@zju.edu.cn

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

patients undergoing elective bone cancer resection surgery

Description

Inclusion Criteria:

(1) undergoing elective bone cancer resection surgery.

Exclusion Criteria:

(1)declined participation in the study.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Complication	This includes embolic events, pulmonary complication, wound complication, acute kidney injury, death. Diagnose according to radiologic examination, sign and symptom	hospital discharge, an average of 10 days

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
6-month mortality		6 months
The rate of perioperative transfusion of allogeneic blood products	This includes blood products such as plasma and platelets, erythrocytes	hospital discharge, an average of 10 days
The coagulation function tests during the perioperative period	This includes thromboelastography result	hospital discharge, an average of 10 days
Wound drainage volume	Accumulated postoperative wound drainage volume	hospital discharge, an average of 10 days
Hemoglobin levels	Hemoglobin levels during hospitalIzation	hospital discharge, an average of 10 days
1-year mortality		1 year
2-year mortality		2 years
3-year mortality		3 years

Collaborators and Investigators

• Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Study record dates

Study Major Dates

• Study Start (Estimated): July 1, 2026
• Primary Completion (Estimated): July 1, 2026
• Study Completion (Estimated): July 1, 2028

Study Registration Dates

• First Submitted: June 22, 2026
• First Submitted That Met QC Criteria: June 22, 2026
• First Posted (Actual): June 25, 2026

Study Record Updates

• Last Update Posted (Actual): June 25, 2026
• Last Update Submitted That Met QC Criteria: June 22, 2026
• Last Verified: June 1, 2026

More Information

Terms related to this study

• Other Study ID Numbers: 2026 0873

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No