Bone Cancer Surgery Prospective Database
24. juni 2026 opdateret af: Second Affiliated Hospital, School of Medicine, Zhejiang University
Bone Cancer Surgery Prospective Database on Perioperative Characteristics and Postoperative Complications
According to the Global Burden of Disease Report, the number of cancer patients worldwide is increasing year by year.
In 2023, there were a total of 18.5 million newly confirmed cases of malignant tumors worldwide, and it is expected to grow to 30.5 million cases by 2050.
Among them, the number of new cases of malignant tumors of bone and articular cartilage increased by 86.4% from 1990 to 2023.
Meanwhile, bone is a particularly common site for tumor metastasis, and almost half of cancer patients are at risk of developing bone metastasis.
Surgical resection is the main treatment method for both primary and secondary bone cancer.
For patients with bone cancer, the main goal of surgical treatment is to maintain the patient's function and mobility by relieving pain, preventing impending fractures and/or nerve compression, or stabilizing pathological fractures.
Surgery for bone cancer often requires extensive exploration, osteotomy, and prosthetic reconstruction, resulting in significant surgical trauma.
The incidence of postoperative complications remains high.
The occurrence of postoperative complications can increase patient pain, prolong hospitalization time, increase medical costs, and even endanger life.
Therefore, reduction of complications and optimizing perioperative management are key issues that urgently need to be addressed in clinical practice.
Studieoversigt
Status
Ikke rekrutterer endnu
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
At present, there is a lack of high-quality evidence-based measures for perioperative management of bone cancer. Previous studies have mainly been retrospective, with common issues such as missing variables, small sample sizes, and single disease types, making it difficult to systematically reveal perioperative pathophysiological patterns and provide reliable evidence for clinical management. Therefore, high-quality prospective studies are urgently needed.
Therefore, this study intends to conduct a prospective cohort study of patients undergoing surgery for bone cancer, establish a perioperative database, clarify the incidence of complications, explore the factors related to perioperative complications, and provide evidence-based support for improving perioperative management and patient prognosis.
Undersøgelsestype
Observationel
Tilmelding (Anslået)
400
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
-
-
Zhejiang
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Hangzhou, Zhejiang, Kina, 310000
- The Second Affiliated Hospital of Zhejiang University anesthesiology department
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Ledende efterforsker:
- Min Yan, Doctor
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Kontakt:
- Min Yan, Doctor
- Telefonnummer: +86 15888210247
- E-mail: zryanmin@zju.edu.cn
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-
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
- Barn
- Voksen
- Ældre voksen
Tager imod sunde frivillige
Ingen
Prøveudtagningsmetode
Ikke-sandsynlighedsprøve
Studiebefolkning
patients undergoing elective bone cancer resection surgery
Beskrivelse
Inclusion Criteria:
- Clinical diagnosis of bone cancer
- Scheduled to undergo elective bone cancer resection surgery
Exclusion Criteria:
- Unable to comply with follow-up
- declined participation in the study
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Complication
Tidsramme: hospital discharge, an average of 10 days
|
This includes embolic events, pulmonary complication, wound complication, acute kidney injury, death.
Diagnose according to radiologic examination, sign and symptom
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hospital discharge, an average of 10 days
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
6 måneders dødelighed
Tidsramme: 6 måneder
|
6 måneder
|
|
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The rate of perioperative transfusion of allogeneic blood products
Tidsramme: hospital discharge, an average of 10 days
|
This includes blood products such as plasma and platelets, erythrocytes
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hospital discharge, an average of 10 days
|
|
The coagulation function tests during the perioperative period
Tidsramme: hospital discharge, an average of 10 days
|
This includes thromboelastography result
|
hospital discharge, an average of 10 days
|
|
Wound drainage volume
Tidsramme: hospital discharge, an average of 10 days
|
Accumulated postoperative wound drainage volume
|
hospital discharge, an average of 10 days
|
|
Hemoglobin levels
Tidsramme: hospital discharge, an average of 10 days
|
Hemoglobin levels during hospitalIzation
|
hospital discharge, an average of 10 days
|
|
1-year mortality
Tidsramme: 1 year
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1 year
|
|
|
2-year mortality
Tidsramme: 2 years
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2 years
|
|
|
3-year mortality
Tidsramme: 3 years
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3 years
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Anslået)
1. juli 2026
Primær færdiggørelse (Anslået)
1. juli 2026
Studieafslutning (Anslået)
1. juli 2028
Datoer for studieregistrering
Først indsendt
22. juni 2026
Først indsendt, der opfyldte QC-kriterier
22. juni 2026
Først opslået (Faktiske)
25. juni 2026
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
29. juni 2026
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
24. juni 2026
Sidst verificeret
1. juni 2026
Mere information
Begreber relateret til denne undersøgelse
Andre undersøgelses-id-numre
- 2026 0873
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
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