Exposome, Pollutants, Biology in the Older Subject: EXPOSAGE (EXPOSAGE)
2026年6月24日 更新者：Centre Hospitalier Universitaire de Nice
Numerous factors, both individual and environmental, can influence aging, an individual's health, and their functional status.
However, the understanding of the combined impact of lifestyle-related exposures (e.g., physical activity, diet, sleep) (personal external exposome), exposures to pollutants (environmental external exposome), and their biological responses (internal exposome)-in other words, the impact of the "exposome" on healthy aging-remains limited, particularly in characterizing the molecular mechanisms associated with these interactions.
Exposome approaches identifying key exposures and molecular mechanisms could lead to a better understanding of how the environment, interacting with health behaviors, can affect functional status.
Thus, the objective of this study is i) to evaluate the links between the external exposome, the internal exposome and the health of older and aging individuals, and ii) to identify biological markers associated with a vulnerable health status in older and aging individuals.
研究概览
研究类型
介入性
注册 (估计的)
400
阶段
- 不适用
联系人和位置
本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。
学习联系方式
- 姓名：Virginie PIOVANO
- 邮箱：piovano.v@chu-nice.fr
研究联系人备份
- 姓名：Olivier GUERIN, PROFESSOR
- 电话号码：0492034194
- 邮箱：guerin.o@chu-nice.fr
学习地点
-
-
-
Nice、法国
- CHU de Nice - Hopital de Cimiez
-
首席研究员：
- Olivier GUERIN, Pr
-
接触：
- Olivier GUERIN, Pr
- 电话号码：0492034194
- 邮箱：guerin.o@chu-nice.fr
-
-
参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
- 成人
- 年长者
接受健康志愿者
是的
描述
Inclusion Criteria:
- Aged 55 or over
- Affiliated with or beneficiaries of a social security scheme
- Signed the informed consent form •-Persons residing in one of the following municipalities : Antibes, Le Bar-sur-Loup, Berre-les-Alpes, Beuil, Blausasc, Breil-sur-Roya, Cabris, Cannes, Carros, Clans, Contes, Drap, L'Escarène, Escragnolles, Fontan, La Gaude, Gilette, Grasse, Lantosque, Levens, Nice, Peillon, Peymeinade, Saint-André-de-la-Roche, Saint-Etienne-de-Tinée, Sospel, Tourrettes-sur-Loup, Vence, Tende
Exclusion Criteria:
- patients currently undergoing intensive drug treatment, including chemotherapy
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
- 主要用途：其他
- 分配：不适用
- 介入模型：单组作业
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
其他：Exposome assessment
|
Visit 1: blood sample, questionnaires on the personal exposome (lifestyle habits (e.g., physical activity, diet, stress) and social characteristics and health status) | ii) Outpatient assessment: wearing a silicone bracelet for 7 days to measure external environmental exposure to pollutants and quantify physical activity | iii) Visit 2: 1-year follow-up of health status
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Frailty (health measure)
大体时间：at baseline and 12 months later
|
Frailty is assessed using the Groningen Frailty Indicator.
The scale comprises 15 items.
The total score ranges from 0 to 25, with a higher score being worse.
|
at baseline and 12 months later
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Functional and health status
大体时间：at baseline and 1 year
|
Disease presence : : Presence (yes/no) of chronic disease
|
at baseline and 1 year
|
|
Physical functional capacities (health measure)
大体时间：at baseline and at 12 months
|
Physical functional capacities are assessed using the Short Physical Performance Battery which assess balance, walking capacities and strength via a sit to stand test
|
at baseline and at 12 months
|
|
Quality of life (health measure)
大体时间：at baseline and 12 months
|
Quality of life is assessed using the SF-12 questionnaire.
The scale comprises 12 items.
|
at baseline and 12 months
|
|
Autonomy (health measure)
大体时间：at baseline and 12 months
|
Autonomy is assessed using the WHOQOL-OLD-AUT questionnaire.
The scale comprises 4 items.
The total score ranges from 4 to 20, with a higher score being better.
|
at baseline and 12 months
|
|
Comorbidity (health measure)
大体时间：at baseline and 12 months
|
Comorbidity is assessed using the Charlson Index which counts the number of comorbidities.
Higher score means greater number of comorbidities and therefore a poorer health.
|
at baseline and 12 months
|
|
Pollutant metabolites (internal exposome/biological measure)
大体时间：at baseline.
|
Presence in the blood metabolome of molecules directly associated with pollutants (initial or biotransformed compounds).
This outcome will be obtained through a metabolomic analysis by very high-resolution mass spectrometry (consisting of the analysis of all small organic molecules (or metabolites)) performed on blood samples taken by a blood sampling.
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at baseline.
|
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DNA and telomere damage (internal exposome/biological measure)
大体时间：at baseline.
|
DNA damage will be obtained through epigenetic analysis by studying miRNAs.
|
at baseline.
|
|
exposure to air pollutants (external environmental exposome measure)
大体时间：at baseline
|
characteristics in terms of air pollution of the living space (quantity of fine particulate matter (PM), ozone (O3), nitrogen dioxide (NO2), or sulfur dioxide (SO2))
|
at baseline
|
|
exposure to pesticides, hydrocarbons, plastics, flame retardant pollutants (external environmental exposome measure)
大体时间：at baseline
|
the exposure will be obtained through a silicone bracelet worn for 7 days by the participant, which will allow the measure of all exposures in the person's daily life.
|
at baseline
|
|
Smoking habits (external personal exposome measure)
大体时间：at baseline.
|
smoking/non-smoking status identified via questionnaire.
|
at baseline.
|
|
Alcohol habits (external personal exposome measure)
大体时间：at baseline
|
consumption volume identified via questionnaire.
|
at baseline
|
|
Self-reported physical activity habits (external personal exposome measure)
大体时间：at baseline
|
volume of physical activity practice over a week identified via questionnaire.
|
at baseline
|
|
Objective-measured physical activity habits (external personal exposome measure)
大体时间：at baseline
|
volume of physical activity practice over a week identified via actigraphy.
|
at baseline
|
|
Socioeconomic characteristic (external personal exposome measure)
大体时间：at baseline
|
level of study identified via questionnaire.
|
at baseline
|
|
Socioeconomic characteristic (external personal exposome measure)
大体时间：at baseline
|
socio-professional category identified via questionnaire.
|
at baseline
|
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Psychological health (external personal exposome measure)
大体时间：at baseline
|
anxiety assessed using the Hospital Anxiety and Depression Scale (HAD).
The scale comprises 14 items.
The total score ranges from 0 to 21, with a higher score being worse.
|
at baseline
|
合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (估计的)
2030年9月1日
初级完成 (估计的)
2031年9月1日
研究完成 (估计的)
2031年9月1日
研究注册日期
首次提交
2026年6月11日
首先提交符合 QC 标准的
2026年6月24日
首次发布 (实际的)
2026年7月1日
研究记录更新
最后更新发布 (实际的)
2026年7月1日
上次提交的符合 QC 标准的更新
2026年6月24日
最后验证
2026年6月1日
更多信息
与本研究相关的术语
其他研究编号
- 25-PP-25
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