Exposome, Pollutants, Biology in the Older Subject: EXPOSAGE (EXPOSAGE)

Numerous factors, both individual and environmental, can influence aging, an individual's health, and their functional status. However, the understanding of the combined impact of lifestyle-related exposures (e.g., physical activity, diet, sleep) (personal external exposome), exposures to pollutants (environmental external exposome), and their biological responses (internal exposome)-in other words, the impact of the "exposome" on healthy aging-remains limited, particularly in characterizing the molecular mechanisms associated with these interactions. Exposome approaches identifying key exposures and molecular mechanisms could lead to a better understanding of how the environment, interacting with health behaviors, can affect functional status. Thus, the objective of this study is i) to evaluate the links between the external exposome, the internal exposome and the health of older and aging individuals, and ii) to identify biological markers associated with a vulnerable health status in older and aging individuals.

Study Overview

• Status: Not yet recruiting
• Conditions: Aging Disorder
• Intervention / Treatment: Other: Exposome assessment

• Study Type: Interventional
• Enrollment (Estimated): 400
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Virginie PIOVANO; Email: piovano.v@chu-nice.fr
• Study Contact Backup: Name: Olivier GUERIN, PROFESSOR; Phone Number: 0492034194; Email: guerin.o@chu-nice.fr

Study Locations

• France
  • Nice, France
    • CHU de Nice - Hopital de Cimiez
    • Principal Investigator: Olivier GUERIN, Pr
    • Contact: Olivier GUERIN, Pr; Phone Number: 0492034194; Email: guerin.o@chu-nice.fr

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Aged 55 or over
• Affiliated with or beneficiaries of a social security scheme
• Signed the informed consent form •-Persons residing in one of the following municipalities : Antibes, Le Bar-sur-Loup, Berre-les-Alpes, Beuil, Blausasc, Breil-sur-Roya, Cabris, Cannes, Carros, Clans, Contes, Drap, L'Escarène, Escragnolles, Fontan, La Gaude, Gilette, Grasse, Lantosque, Levens, Nice, Peillon, Peymeinade, Saint-André-de-la-Roche, Saint-Etienne-de-Tinée, Sospel, Tourrettes-sur-Loup, Vence, Tende

Exclusion Criteria:

• patients currently undergoing intensive drug treatment, including chemotherapy

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

Other: Exposome assessment

Other: Exposome assessment; Visit 1: blood sample, questionnaires on the personal exposome (lifestyle habits (e.g., physical activity, diet, stress) and social characteristics and health status) | ii) Outpatient assessment: wearing a silicone bracelet for 7 days to measure external environmental exposure to pollutants and quantify physical activity | iii) Visit 2: 1-year follow-up of health status

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Frailty (health measure)	Frailty is assessed using the Groningen Frailty Indicator. The scale comprises 15 items. The total score ranges from 0 to 25, with a higher score being worse.	at baseline and 12 months later

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Functional and health status	Disease presence : : Presence (yes/no) of chronic disease	at baseline and 1 year
Physical functional capacities (health measure)	Physical functional capacities are assessed using the Short Physical Performance Battery which assess balance, walking capacities and strength via a sit to stand test	at baseline and at 12 months
Quality of life (health measure)	Quality of life is assessed using the SF-12 questionnaire. The scale comprises 12 items.	at baseline and 12 months
Autonomy (health measure)	Autonomy is assessed using the WHOQOL-OLD-AUT questionnaire. The scale comprises 4 items. The total score ranges from 4 to 20, with a higher score being better.	at baseline and 12 months
Comorbidity (health measure)	Comorbidity is assessed using the Charlson Index which counts the number of comorbidities. Higher score means greater number of comorbidities and therefore a poorer health.	at baseline and 12 months
Pollutant metabolites (internal exposome/biological measure)	Presence in the blood metabolome of molecules directly associated with pollutants (initial or biotransformed compounds). This outcome will be obtained through a metabolomic analysis by very high-resolution mass spectrometry (consisting of the analysis of all small organic molecules (or metabolites)) performed on blood samples taken by a blood sampling.	at baseline.
DNA and telomere damage (internal exposome/biological measure)	DNA damage will be obtained through epigenetic analysis by studying miRNAs.	at baseline.
exposure to air pollutants (external environmental exposome measure)	characteristics in terms of air pollution of the living space (quantity of fine particulate matter (PM), ozone (O3), nitrogen dioxide (NO2), or sulfur dioxide (SO2))	at baseline
exposure to pesticides, hydrocarbons, plastics, flame retardant pollutants (external environmental exposome measure)	the exposure will be obtained through a silicone bracelet worn for 7 days by the participant, which will allow the measure of all exposures in the person's daily life.	at baseline
Smoking habits (external personal exposome measure)	smoking/non-smoking status identified via questionnaire.	at baseline.
Alcohol habits (external personal exposome measure)	consumption volume identified via questionnaire.	at baseline
Self-reported physical activity habits (external personal exposome measure)	volume of physical activity practice over a week identified via questionnaire.	at baseline
Objective-measured physical activity habits (external personal exposome measure)	volume of physical activity practice over a week identified via actigraphy.	at baseline
Socioeconomic characteristic (external personal exposome measure)	level of study identified via questionnaire.	at baseline
Socioeconomic characteristic (external personal exposome measure)	socio-professional category identified via questionnaire.	at baseline
Psychological health (external personal exposome measure)	anxiety assessed using the Hospital Anxiety and Depression Scale (HAD). The scale comprises 14 items. The total score ranges from 0 to 21, with a higher score being worse.	at baseline

Collaborators and Investigators

• Sponsor: Centre Hospitalier Universitaire de Nice

Study record dates

Study Major Dates

• Study Start (Estimated): September 1, 2030
• Primary Completion (Estimated): September 1, 2031
• Study Completion (Estimated): September 1, 2031

Study Registration Dates

• First Submitted: June 11, 2026
• First Submitted That Met QC Criteria: June 24, 2026
• First Posted (Actual): July 1, 2026

Study Record Updates

• Last Update Posted (Actual): July 1, 2026
• Last Update Submitted That Met QC Criteria: June 24, 2026
• Last Verified: June 1, 2026

More Information

Terms related to this study

• Other Study ID Numbers: 25-PP-25

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No