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MyocarditIRM-Génétique - Genetic Sub-study of the French Cohort of Acute Myocarditis Cases Diagnosed by MRI (MyocarditIRM-G)

2026年7月16日更新者：French Cardiology Society

The aim of this retrospective, non-interventional study is to assess the prevalence and describe the genetic variants found in a cohort of patients with acute myocarditis confirmed by MRI. This is a study linked to the MyocarditIRM cohort, designed to collect genetic test results obtained as part of routine clinical care.

研究概览

地位

主动，不招人

条件

急性心肌炎

研究类型

观察性的

注册 (估计的)

602

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习地点

法国
- France
  - Poitiers、France、法国、86000
    - CHU De Poitiers

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

成人
年长者

接受健康志愿者

不

取样方法

非概率样本

研究人群

All patients included in myocarditIRM who have genetic data

描述

Inclusion Criteria:

Patient enrolled in MyocarditIRM
Patient who has undergone genetic testing

Exclusion Criteria:

Patient who has objected to the reuse of their data

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

团体/队列数

队列和干预

团体/队列
Patients included in Cohort MyocarditIRM with genetic testing results available Retrospective observational study using data extracted from the hospital data warehouse and linked to the French National Health Data System (SNDS). Genetic analyses were performed as part of routine clinical care and were retrospectively collected for research purposes. No study-specific intervention was performed.

研究衡量的是什么？

主要结果指标

结果测量	大体时间
Prevalence and characterization of genetic variants (genes involved and ACMG classification) in patients with MRI-confirmed acute myocarditis. 大体时间：From index hospitalization for acute myocarditis up to 10 years of follow-up (including SNDS linkage when available)	From index hospitalization for acute myocarditis up to 10 years of follow-up (including SNDS linkage when available)

次要结果测量

结果测量	措施说明	大体时间
All-cause mortality 大体时间：From index hospitalization for acute myocarditis up to 10 years of follow-up (including SNDS linkage when available)	All-cause mortality during follow-up	From index hospitalization for acute myocarditis up to 10 years of follow-up (including SNDS linkage when available)
Cardiovascular mortality 大体时间：From index hospitalization for acute myocarditis up to 10 years of follow-up (including SNDS linkage when available)	Cardiovascular mortality during follow-up	From index hospitalization for acute myocarditis up to 10 years of follow-up (including SNDS linkage when available)
Major adverse cardiovascular events 大体时间：During index hospitalization and up to 10 years of follow-up (via SNDS linkage and medical records)	Occurrence of major adverse cardiovascular events, including heart failure requiring hospitalization, newly diagnosed dilated cardiomyopathy not present prior to the myocarditis episode, ventricular arrhythmias, high-degree atrioventricular block, implantation of an implantable cardioverter-defibrillator (ICD), pacemaker, wearable cardioverter-defibrillator (life vest), or implantable loop recorder, recurrent myocarditis, and heart transplantation.	During index hospitalization and up to 10 years of follow-up (via SNDS linkage and medical records)
Cardiac MRI sequelae 大体时间：During follow-up imaging performed as part of routine clinical care, up to 10 years after index myocarditis episode	Presence of myocardial sequelae on cardiac magnetic resonance imaging (MRI) during follow-up in patients who underwent follow-up imaging as part of routine clinical care	During follow-up imaging performed as part of routine clinical care, up to 10 years after index myocarditis episode

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

French Cardiology Society

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (实际的)

2025年7月15日

初级完成 (估计的)

2027年1月1日

研究完成 (估计的)

2027年1月1日

研究注册日期

首次提交

2026年6月11日

首先提交符合 QC 标准的

2026年7月16日

首次发布 (实际的)

2026年7月21日

研究记录更新

最后更新发布 (实际的)