Predictive Factors for a Positive Exercise Bronchial Hyperresponsiveness Test (PredEIB)
研究概览
地位
条件
详细说明
Exertional dyspnea is a frequent reason for consultation in pediatric pulmonology. The perception of dyspnea varies from one child to another, with some children over- or under- perceiving its intensity. Dyspnea has a significant impact on a child's daily life and quality of life and, in pediatrics, always raises the suspicion of exercise-induced asthma. Current guidelines recommend performing an exercise challenge test to confirm or rule out exercise-induced bronchoconstriction (EIB) if it is suspected. However, this test is not widely available. The objective of this research is to identify the clinical and respiratory functional factors predictive of a positive exercise challenge test in children.
The potential benefit of this study is to better identify individuals who would benefit from undergoing an exercise challenge test.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Nancy、法国
- CHRU de Nancy
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参与标准
资格标准
适合学习的年龄
- 孩子
- 成人
接受健康志愿者
取样方法
研究人群
描述
Inclusion Criteria:
- Children aged 5 to 18 years who performed an exercise challenge test during the years 2024 and 2025
Exclusion Criteria:
- Children with doctor-diagnosed asthma
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
|---|
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Children without exercise-induced bronchocontriction
Children with a reduction in FEV1 < 10% from baseline after the exercise challenge test
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Children with exercise-induced bronchocontriction
Children with a reduction in FEV1 ≥ 10% from baseline after the exercise challenge test
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Presence of wheezing at exercise
大体时间：The test duration (3 hours)
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Presence of reported exercise-induced wheezing, as documented in the subject's electronic medical record (yes/no; binary variable).
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The test duration (3 hours)
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Presence of reported dyspnea at exercise
大体时间：The test duration 3 hours
|
Presence of reported exercise-induced dyspnea, as documented in the subject's electronic medical record (yes/no; binary variable).
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The test duration 3 hours
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Presence of reported cough at exercise
大体时间：The test duration 3 hours
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Presence of reported exercise-induced cough, as documented in the subject's electronic medical record (yes/no; binary variable).
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The test duration 3 hours
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Presence of reported chest tightness at exercise
大体时间：The test duration 3 hours
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Presence of reported exercise-induced chest tightness, as documented in the subject's electronic medical record (yes/no; binary variable).
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The test duration 3 hours
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Functional parameters - FEV1 z-score at baseline
大体时间：The test duration 3 hours
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Spirometric parameters measured before exercise testing - FEV1 z-score (forced expiratory volume in 1 sec) from spirometry performed before exercise testing and documented in the electronic folder of the patient
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The test duration 3 hours
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Reported atopy
大体时间：The test duration 3 hours
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Presence of asthma or atopy history, as documented in the subject's electronic medical record (yes/no; binary variable).
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The test duration 3 hours
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Reported clinical history
大体时间：The test duration 3 hours
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Reported early respiratory history (≥ 3 wheezing episodes before the age of 3 years; at least one episode of pneumonia or atelectasis), from the clinical history recorded in the electronic folder of the patients (yes/no, binary variable)
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The test duration 3 hours
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Functional parameters - FEV1/FVC z-score at baseline
大体时间：The test duration 3 hours
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Spirometric parameters measured before exercise testing - FEV1/FVC z-score (FVC = forced vital capacity) from spirometry performed before exercise testing and documented in the electronic folder of the patient
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The test duration 3 hours
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合作者和调查者
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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