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Predictive Factors for a Positive Exercise Bronchial Hyperresponsiveness Test (PredEIB)

11 augusti 2026 uppdaterad av: Dr. Iulia IOAN, Central Hospital, Nancy, France

Exertional dyspnea has a significant impact on a child's daily life. Current guidelines recommend performing an exercise challenge test to confirm or rule out exercise-induced bronchoconstriction (EIB). But the test is not widely available. The objective of this research is to identify the clinical and respiratory functional factors predictive of a positive exercise challenge test in children.

Studieöversikt

Status

Avslutad

Betingelser

Astma (diagnos)

Detaljerad beskrivning

Exertional dyspnea is a frequent reason for consultation in pediatric pulmonology. The perception of dyspnea varies from one child to another, with some children over- or under- perceiving its intensity. Dyspnea has a significant impact on a child's daily life and quality of life and, in pediatrics, always raises the suspicion of exercise-induced asthma. Current guidelines recommend performing an exercise challenge test to confirm or rule out exercise-induced bronchoconstriction (EIB) if it is suspected. However, this test is not widely available. The objective of this research is to identify the clinical and respiratory functional factors predictive of a positive exercise challenge test in children.

The potential benefit of this study is to better identify individuals who would benefit from undergoing an exercise challenge test.

Studietyp

Observationell

Inskrivning (Faktisk)

100

Kontakter och platser

Det här avsnittet innehåller kontaktuppgifter för dem som genomför studien och information om var denna studie genomförs.

Studieorter

Frankrike
- - Nancy, Frankrike
    - CHRU de Nancy

Deltagandekriterier

Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.

Urvalskriterier

Åldrar som är berättigade till studier

Barn
Vuxen

Tar emot friska volontärer

Nej

Testmetod

Icke-sannolikhetsprov

Studera befolkning

Children referred by a pediatric pulmonologist to the pediatric respiratory function testing department in 2024 and 2025 for an exercise test. Children with asthma diagnosed by a physician will be excluded.

Beskrivning

Inclusion Criteria:

Children aged 5 to 18 years who performed an exercise challenge test during the years 2024 and 2025

Exclusion Criteria:

Children with doctor-diagnosed asthma

Studieplan

Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.

Hur är studien utformad?

Designdetaljer

Antal grupper/kohorter

Kohorter och interventioner

Grupp / Kohort
Children without exercise-induced bronchocontriction Children with a reduction in FEV1 < 10% from baseline after the exercise challenge test
Children with exercise-induced bronchocontriction Children with a reduction in FEV1 ≥ 10% from baseline after the exercise challenge test

Vad mäter studien?

Primära resultatmått

Resultatmått	Åtgärdsbeskrivning	Tidsram
Presence of wheezing at exercise Tidsram: The test duration (3 hours)	Presence of reported exercise-induced wheezing, as documented in the subject's electronic medical record (yes/no; binary variable).	The test duration (3 hours)

Sekundära resultatmått

Resultatmått	Åtgärdsbeskrivning	Tidsram
Presence of reported dyspnea at exercise Tidsram: The test duration 3 hours	Presence of reported exercise-induced dyspnea, as documented in the subject's electronic medical record (yes/no; binary variable).	The test duration 3 hours
Presence of reported cough at exercise Tidsram: The test duration 3 hours	Presence of reported exercise-induced cough, as documented in the subject's electronic medical record (yes/no; binary variable).	The test duration 3 hours
Presence of reported chest tightness at exercise Tidsram: The test duration 3 hours	Presence of reported exercise-induced chest tightness, as documented in the subject's electronic medical record (yes/no; binary variable).	The test duration 3 hours
Functional parameters - FEV1 z-score at baseline Tidsram: The test duration 3 hours	Spirometric parameters measured before exercise testing - FEV1 z-score (forced expiratory volume in 1 sec) from spirometry performed before exercise testing and documented in the electronic folder of the patient	The test duration 3 hours
Reported atopy Tidsram: The test duration 3 hours	Presence of asthma or atopy history, as documented in the subject's electronic medical record (yes/no; binary variable).	The test duration 3 hours
Reported clinical history Tidsram: The test duration 3 hours	Reported early respiratory history (≥ 3 wheezing episodes before the age of 3 years; at least one episode of pneumonia or atelectasis), from the clinical history recorded in the electronic folder of the patients (yes/no, binary variable)	The test duration 3 hours
Functional parameters - FEV1/FVC z-score at baseline Tidsram: The test duration 3 hours	Spirometric parameters measured before exercise testing - FEV1/FVC z-score (FVC = forced vital capacity) from spirometry performed before exercise testing and documented in the electronic folder of the patient	The test duration 3 hours

Samarbetspartners och utredare

Det är här du hittar personer och organisationer som är involverade i denna studie.

Sponsor

Central Hospital, Nancy, France

Studieavstämningsdatum

Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.

Studera stora datum

Studiestart (Faktisk)

30 maj 2024

Primärt slutförande (Faktisk)

1 juni 2026

Avslutad studie (Faktisk)

8 juni 2026

Studieregistreringsdatum

Först inskickad

27 juli 2026

Först inskickad som uppfyllde QC-kriterierna

11 augusti 2026

Första postat (Faktisk)

14 augusti 2026

Uppdateringar av studier

Senaste uppdatering publicerad (Faktisk)