Diaphragmatic Ultrasound and Hypoxic Burden in "Osa" (osa)
Diaphragmatic Ultrasound and Muscle Reserve in Obstructive Sleep Apnea Syndrome: Association With Nocturnal Hypoxic Burden and Polysomnographic Parameters
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Primary objective To investigate the association between diaphragmatic ultrasound-derived indices, particularly diaphragmatic reserve, and hypoxic burden in patients with OSA.
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Secondary objectives:
- To characterize diaphragmatic thickness, thickening fraction, and excursion in patients with OSA.
- To determine the relationship between diaphragmatic ultrasound parameters and polysomnographic parameters as: AHI, ODI, T90, mean SpO₂, minimum SpO₂, REM-AHI, supine AHI, arousal index.
研究概览
地位
条件
详细说明
Obstructive sleep apnea (OSA) is a serious health condition that has been estimated to affect nearly 936 million adults aged between 30 and 69 worldwide according to recent to recent global estimates.
OSA is therefore a very common condition that results in several health consequences, such as cardiovascular pathology, metabolic disruptions, cognitive decline .
attended Polysomnography (PSG) is considered the gold standard for diagnosis of OSA ,with apnea-hypopnea index (AHI) as the more frequently used indicator of disease severity.
However in recent studies AHI have been shown to be inconsistently related to adverse consequences of OSA Hypoxic burden defined as the sum of individual area under oxygen saturation curves related to every respiratory event obtained by pulse oximeter during the total sleep time, has been suggested as a more accurate measure of OSA severity relating to symptoms and adverse effects.
The diaphragm as the most important muscle of respiration, can impact OSA severity although the extent of such effect is still unclear.
研究类型
注册 (估计的)
联系人和位置
学习联系方式
- 姓名：Abdulrahman Galal Salih, masters degree
- 电话号码：00201111532712
- 邮箱：abdogalal231295@gmail.com
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
adult patients who are confirmed to have OSA by polysomnography
描述
Inclusion Criteria:
- Aged > 18 years.
- Newly diagnosed OSA using PSG and meeting AASM diagnostic criteria.
- Treatment-naïve with respect to CPAP or other positive-airway-pressure therapy.
- Provide informed consent.
Exclusion Criteria:
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Respiratory diseases:
Bronchial asthma, COPD, bronchiectasis, interstitial lung disease, neuromuscular respiratory disease
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Neurological/diaphragmatic disorders:
Neuromuscular disorders, muscular dystrophies, previous major thoracic surgery affecting the diaphragm
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Other conditions:
decompensated heart failure, significant pulmonary hypertension, active malignancy acute respiratory infection
学习计划
研究是如何设计的？
设计细节
- 观测模型：CASE_ONLY
- 时间观点：CROSS_SECTIONAL
研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
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Establish a correlation between OSA severity and degree of diaphragmatic dysfunction using hypoxic burden related to diaphragmatic ultrasound parameters
大体时间：Baseline
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Baseline
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the association between hypoxic burden and diaphragmatic thickness fraction after adjusted for AHI and BMI
大体时间：Baseline
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Baseline
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合作者和调查者
出版物和有用的链接
一般刊物
- Bordoni B, Escher AR, Toccafondi A, Mapelli L, Banfi P. Obstructive Sleep Apnea and Role of the Diaphragm. Cureus. 2022 Sep 10;14(9):e29004. doi: 10.7759/cureus.29004. eCollection 2022 Sep.
- Rundo JV. Obstructive sleep apnea basics. Cleve Clin J Med. 2019 Sep;86(9 Suppl 1):2-9. doi: 10.3949/ccjm.86.s1.02.
研究记录日期
研究主要日期
学习开始 (估计的)
初级完成 (估计的)
研究完成 (估计的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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