Diaphragmatic Ultrasound and Hypoxic Burden in "Osa" (osa)

November 7, 2026 updated by: Abdelrahman Galal Salih, Assiut University

Diaphragmatic Ultrasound and Muscle Reserve in Obstructive Sleep Apnea Syndrome: Association With Nocturnal Hypoxic Burden and Polysomnographic Parameters

Primary objective To investigate the association between diaphragmatic ultrasound-derived indices, particularly diaphragmatic reserve, and hypoxic burden in patients with OSA.
Secondary objectives:
1. To characterize diaphragmatic thickness, thickening fraction, and excursion in patients with OSA.
2. To determine the relationship between diaphragmatic ultrasound parameters and polysomnographic parameters as: AHI, ODI, T90, mean SpO₂, minimum SpO₂, REM-AHI, supine AHI, arousal index.

Study Overview

Status

Not yet recruiting

Conditions

Obstructive Sleep Apnea

Detailed Description

Obstructive sleep apnea (OSA) is a serious health condition that has been estimated to affect nearly 936 million adults aged between 30 and 69 worldwide according to recent to recent global estimates.

OSA is therefore a very common condition that results in several health consequences, such as cardiovascular pathology, metabolic disruptions, cognitive decline .

attended Polysomnography (PSG) is considered the gold standard for diagnosis of OSA ,with apnea-hypopnea index (AHI) as the more frequently used indicator of disease severity.

However in recent studies AHI have been shown to be inconsistently related to adverse consequences of OSA Hypoxic burden defined as the sum of individual area under oxygen saturation curves related to every respiratory event obtained by pulse oximeter during the total sleep time, has been suggested as a more accurate measure of OSA severity relating to symptoms and adverse effects.

The diaphragm as the most important muscle of respiration, can impact OSA severity although the extent of such effect is still unclear.

Study Type

Observational

Enrollment (Estimated)

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Name: Abdulrahman Galal Salih, masters degree
Phone Number: 00201111532712
Email: abdogalal231295@gmail.com

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

adult patients who are confirmed to have OSA by polysomnography

Description

Inclusion Criteria:

Aged > 18 years.
Newly diagnosed OSA using PSG and meeting AASM diagnostic criteria.
Treatment-naïve with respect to CPAP or other positive-airway-pressure therapy.
Provide informed consent.

Exclusion Criteria:

Respiratory diseases:

Bronchial asthma, COPD, bronchiectasis, interstitial lung disease, neuromuscular respiratory disease
Neurological/diaphragmatic disorders:

Neuromuscular disorders, muscular dystrophies, previous major thoracic surgery affecting the diaphragm
Other conditions:

decompensated heart failure, significant pulmonary hypertension, active malignancy acute respiratory infection

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Observational Models: CASE_ONLY
Time Perspectives: CROSS_SECTIONAL

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Establish a correlation between OSA severity and degree of diaphragmatic dysfunction using hypoxic burden related to diaphragmatic ultrasound parameters Time Frame: Baseline	Baseline
the association between hypoxic burden and diaphragmatic thickness fraction after adjusted for AHI and BMI Time Frame: Baseline	Baseline

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Assiut University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

December 1, 2026

Primary Completion (Estimated)

November 1, 2027

Study Completion (Estimated)

January 1, 2028

Study Registration Dates

First Submitted

October 27, 2026

First Submitted That Met QC Criteria

November 7, 2026

First Posted (Actual)

November 13, 2026

Study Record Updates

Last Update Posted (Actual)