Statistical Analysis of Vlagtwedde-Vlaardingen Data Set

To determine the effects in early adulthood of asthma, increased bronchial responsiveness, markers of allergy and smoking on pulmonary function level and the effects of these same risk factors on subsequent decline in pulmonary function, because these early adult factors presumably profoundly influence the risk for chronic obstructive pulmonary disease.

Study Overview

• Status: Completed
• Conditions: Lung Diseases, Obstructive; Chronic Obstructive Pulmonary Disease; Asthma

Detailed Description

DESIGN NARRATIVE:

The questions studied included whether the above named risk factors reduced the maximally attained level of pulmonary function in early adulthood, foreshortened the postulated stability of level of pulmonary function between age 18 and 35 and/or unfavorably affected subsequent decline in level of pulmonary function. FEV1/h2, VC/h2 and FEV1/IVC were studied, using graphic smooth techniques and regression analyses techniques on both cross-sectional and longitudinal datasets. In addition, the investigators tested the hypothesis stating that early adult symptoms of asthma, increased bronchial responsiveness, markers of allergy influenced who became a smoker, influenced the amount smoked and/or influenced who stopped smoking relatively early in adult life, using logistic regression analyses and survival analyses.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.

• Study Type: Observational

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: No older than 100 years (Child, Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Male

Description

No eligibility criteria

Study Plan

How is the study designed?

Collaborators and Investigators

• Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Publications and helpful links

General Publications

• Shimada M, Matsumata T, Itasaka H, Shirabe K, Taketomi A, Sugimachi K. The prediction of portal pressure: a multivariate analysis of clinical data and intraoperative portal pressure. Surg Today. 1994;24(4):309-12. doi: 10.1007/BF02348558.
• Xu X, Weiss ST, Dockery DW, Schouten JP, Rijcken B. Comparing FEV1 in adults in two community-based studies. Chest. 1995 Sep;108(3):656-62. doi: 10.1378/chest.108.3.656.
• Rijcken B, Schouten JP, Xu X, Rosner B, Weiss ST. Airway hyperresponsiveness to histamine associated with accelerated decline in FEV1. Am J Respir Crit Care Med. 1995 May;151(5):1377-82. doi: 10.1164/ajrccm.151.5.7735588.
• Xu X, Laird N, Dockery DW, Schouten JP, Rijcken B, Weiss ST. Age, period, and cohort effects on pulmonary function in a 24-year longitudinal study. Am J Epidemiol. 1995 Mar 15;141(6):554-66. doi: 10.1093/oxfordjournals.aje.a117471.

Study record dates

Study Major Dates

• Study Start: September 1, 1992
• Study Completion (Actual): February 1, 1995

Study Registration Dates

• First Submitted: May 25, 2000
• First Submitted That Met QC Criteria: May 25, 2000
• First Posted (Estimate): May 26, 2000

Study Record Updates

• Last Update Posted (Estimate): March 16, 2016
• Last Update Submitted That Met QC Criteria: March 15, 2016
• Last Verified: April 1, 2001

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Respiratory Tract Diseases; Lung Diseases; Lung Diseases, Obstructive; Pulmonary Disease, Chronic Obstructive
• Other Study ID Numbers: 4343 (Company internal); R03HL049460 (U.S. NIH Grant/Contract)