- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00154570
24 Hour Esophageal and Electrogastrography to Investigate the Mechanism of Reflux Esophagitis
Integrating Simultaneous Recording of 24 Hour Esophageal pH and Electrogastrography to Investigate the Mechanism of Reflux Esophagitis
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Gastroesophageal regurgitation with acid is considered the main cause of reflux esophagitis, but the current theory of transient relaxation of LES (TLESR) fails to explain all the mechanisms of reflux esophagitis, for a rather high proportion of reflux esophagitis patients has concomitant other functional gastrointestinal disorder, particularly gastric motility dysfunction. Thus, these patients could even not effectively respond to proton pump inhibitor alone. Abnormal gastric emptying and antral dysmotility has been considered related to reflux esophagitis. EGG is a promising noninvasive tool in study of gastric electric activity and motility, and the application of gastric electric stimulation (GES) in the modulation of gastric motility disorder and even reflux esophagitis has been in proceeding; however, there is lacking study by using EGG to integrate gastric electrical potentials, gastric motility and gastroesophageal reflux in investigating the mechanism of reflux esophagitis till now; especially, no known literature by combined simultaneous prolong ambulatory esophageal pH and EGG recordings has been reported. It has been known in EGG study that gastric dysrhythmias (tachy- and brady-) related smooth muscle function of stomach and dysfunctional gastric emptying.
In a preliminary findings of simultaneous prolong ambulatory esophageal pH and EGG recordings by our study group, we found that gastroesophageal reflux with acid tends in the status of abnormal RSA. Thus, we propose the following hypotheses: (1) Gastric dysrhythmias may predispose the occurrence of gastroesophageal reflux. We plan to use the recorder of esophageal pH and gastric electric potentials developed in Institute of Medical Engineering, National Taiwan University, combining with the unique design of simultaneous 24 hour ambulatory esophageal pH and EGG recordings and Matlab analysis of RSA-pH, to explore the relationship of gastric electric potentials and reflux esophagitis.
Objectives: (1) Use simultaneous 24 hour ambulatory esophageal pH metry and EGG to integrate RSA and esophageal pH to explore whether a specific RSA prone to gastroesophageal reflux; or whether gastroesophageal reflux influence gastric electric activity; (2) Integrate RSA and esophageal pH with event of GI symptoms and daily activity to explore whether symptoms are resulted from acid reflux or gastric dysrhythmias.
Materials and methods: Recruits 25 healthy and 25 previously diagnosed reflux esophagitis patients as volunteers to receive the followings:
- GI and GERD symptom questionnaire with score of severity and frequency, and quality of life (QoL).
- 24-hour ambulatory esophageal pH recording: total numbers of reflux episodes, total duration of pH < 4 and DeMester score. They will be classified into: pathologic (pH < 4, > 4%且DeMeester score > 14.72 ) and non-pathologic (pH < 4, < 4% and DeMeester score < 14.72).
- 24-hour ambulatory EGG recording: Use RSA to evaluate the quantity and quality of gastric electrical potentials. They will be classified into normal (3cpm), tachyrhythmia (> 3cpm), and bradyrhythmia (< 3cpm) three groups.
- Use Matlab soft ware to integrate the data of simultaneous 24-hour esophageal pH value and RSA with events of symptoms and daily activities (meal time, postprandial, fasting, sleeping, and exercise).
Study Type
Enrollment
Contacts and Locations
Study Contact
- Name: Bor-Ru Lin, M.D.
- Phone Number: 7788 886-2-23123456
- Email: brlin@ha.mc.ntu.edu.tw
Study Contact Backup
- Name: Jau-Min Wong, M.D. & Ph.D.
- Phone Number: 5696 886-2-23123456
- Email: jmwong@ha.mc.ntu.edu.tw
Study Locations
-
-
-
Taipei, Taiwan, 10016
- Recruiting
- National Taiwan University Hospital
-
Contact:
- Jau-Min Wong, M.D. & Ph.D.
- Phone Number: 5696 886-2-23123456
- Email: jmwong@ha.mc.ntu.edu.tw
-
Principal Investigator:
- Bor-Ru Lin, M.D.
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- GERD questionnaire with heartburn or acid regurgitation with a frequency at least once weekly.
- Endoscopic esophagitis.
Exclusion Criteria:
- A history of esophageal, gastric or abdominal surgery.
- Gastric or esophageal cancer.
- Esophageal varices.
- Concomittant severe systemic disease.
Study Plan
How is the study designed?
Design Details
- Observational Models: Defined Population
- Time Perspectives: Other
Collaborators and Investigators
Investigators
- Principal Investigator: Bor-Ru Lin, M.D., National Taiwan University Hospital
Study record dates
Study Major Dates
Study Start
Study Completion
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 9261701469
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Reflux Esophagitis
-
Universitair Ziekenhuis BrusselUnknownAcid Reflux Esophagitis | Non-acid Reflux EsophagitisBelgium
-
Eisai Co., Ltd.Completed
-
Xijing Hospital of Digestive DiseasesShaanxi Provincial People's Hospital; Baoji Central Hospital; Hanzhong Central... and other collaboratorsUnknownRefractory Reflux EsophagitisChina
-
AstraZenecaCompletedRefractory Reflux EsophagitisJapan
-
Eisai Co., Ltd.CompletedRefractory Reflux EsophagitisJapan
-
AstraZenecaCompletedGastroesophageal Reflux Disease | Erosive Esophagitis | Reflux EsophagitisUnited States
-
Seoul National University Bundang HospitalCompletedNon-erosive Reflux Disease (NERD) | Reflux Esophagitis (RE) | Functional Heartburn (FH)Korea, Republic of
-
Trio Medicines Ltd.Ferring PharmaceuticalsCompletedReflux OesophagitisUnited Kingdom
-
Trio Medicines Ltd.Ferring PharmaceuticalsCompletedReflux OesophagitisUnited Kingdom
-
AstraZenecaCompletedRepeatedly Recurring Esophagitis | Relapsing Reflux EsophagitisJapan
Clinical Trials on EGG, 24 hour esophageal pH monitor
-
Assiut UniversityUnknownIrritable Bowel Syndrome | GERD | Non-erosive Reflux Disease | Functional Esophageal Disorders
-
Asian Institute of Gastroenterology, IndiaRecruitingEsophageal Diseases | Esophagitis | Reflux DiseaseIndia
-
Sheffield Teaching Hospitals NHS Foundation TrustRecruitingColorectal Cancer | Atrial Fibrillation New OnsetUnited Kingdom
-
Fatma DemirbaşCompletedGastroesophageal RefluxTurkey
-
Mayo ClinicNational Institutes of Health (NIH)CompletedBarrett's EsophagusUnited States
-
University of Texas Southwestern Medical CenterDepartment of UrologyNo longer availableHydronephrosis | Multicystic-dysplastic Kidney
-
Ivashkin Vladimir TrofimovichAbbottCompletedGastroesophageal Reflux Disease (GERD)Russian Federation
-
The Functional Gut ClinicRosa BiotechRecruiting
-
University of FloridaTakedaTerminatedChronic Obstructive Pulmonary Disease | Gastroesophageal RefluxUnited States