- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00186719
How Smoking Causes COPD: Examination of Immune System Changes
Study Overview
Status
Conditions
Detailed Description
The mechanism by which smoking leads to damage to lung tissue in susceptible hosts, is uncertain. Recently there has been description of specific changes (that is reduction) in the number and activity of certain key immune cell types - dendritic cells- as a result of cigarette smoke exposure. This work was done in animal models and we would like to develop methods that will allow us to examine if similar changes occur in humans who smoke. Reduced number and activity of dendritic cells would be expected to lead to increased incidence of infection - a common problem in patients with COPD.
Since dendritic cells come to the lung from the bloodstream, and one can detect them in the circulation, we will look at the dendritic cells that are present in the peripheral blood.
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Contact
- Name: Susan E Carruthers, MLT
- Phone Number: 2208 905-522-1155
- Email: scarruth@stjosham.on.ca
Study Contact Backup
- Name: Sarah E Goodwin, BA RRT CCRC
- Phone Number: 6130 905-522-1155
- Email: sgoodwin@stjosham.on.ca
Study Locations
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Ontario
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Hamilton, Ontario, Canada, L8N 4A6
- Recruiting
- St Joseph's Healthcare
-
Contact:
- Gerard Cox, MB FRCPC FRCPI
- Phone Number: 5039 905-522-1155
- Email: coxp@mcmaster.ca
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Contact:
- Martin Stampfli, PhD
- Phone Number: 22473 905-525-9140
- Email: stampfli@mcmaster.ca
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Principal Investigator:
- Gerard Cox, MB FRCPC FRCPI
-
Sub-Investigator:
- Martin Stampfli, PhD
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Age > 40 years
- Healthy Subjects - Non smokers
- FEV1/FVC > 70% predicted
- Current Smokers - > 10 pack year smoking history
- FEV1/FVC > 70% predicted
- Current Smokers with COPD - > 10 pack year smoking history
- FEV1/FVC < 70% predicted
- Able to give informed consent
Exclusion Criteria:
- Healthy Subjects - Reside with smokers
- History of lung disease
- Current Smokers - History of lung disease
Study Plan
How is the study designed?
Design Details
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Gerard Cox, MB FRCPC FRCPI, McMaster University
Study record dates
Study Major Dates
Study Start
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 02-2182
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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