- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00220610
REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION IN the Treatment of DEPRESSION
Right Parietal Inhibition With rTMS in the Treatment of Depression
Subjects received rTMS daily on 10 consecutive weekdays (five sessions per week), during 20 minutes per session.During the rTMS session, the coil was centered flat over the right parietal cortex.
We follow the patient during 12 weeks after the 2 weeks of tms (follow-up period) to measure the depression with different rating scales.
We hypothesized that rTMS has a positive effect in the treatment of depression
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment
Phase
- Phase 2
Contacts and Locations
Study Contact
- Name: Judith van der Riet, Drs.
- Phone Number: 0031-20-5108562
- Email: j.vanderriet@slaz.nl
Study Locations
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-
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Amsterdam, Netherlands, 1061 AE
- Recruiting
- st. Lucas Andreas Ziekenhuis/ Hospital
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Contact:
- Judith van der Riet, Drs
- Phone Number: 0031-20-5108562
- Email: j.vanderriet@slaz.nl
-
Contact:
- G.F Koerselman, Prof.dr.
- Phone Number: 0031-20-5108562
- Email: f.koerselman@slaz.nl
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-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- In and outpatients aged between 16 and 65 who met DSM-IV criteria for major depressive episode, and who had a score of 25 or higher on the 10-item Montgomery Asberg Depression Rating Scale (MADRS) were included
Exclusion Criteria:
- A history of epilepsy and any other medical disorder that should preclude the administration of rTMS. Only SSRI's, Mirtazapine and Promethazine as psychotropic medication was accepted if the dosage of antidepressive medication had not been changed for 6 weeks, and if the dosage of Promethazine had not been changed for 2 weeks prior to inclusion. Antidepressive medication had to remain stable during the 14 weeks of the study.
Furthermore: schizophrenic disorder, a piece if metal in the brain, pacemaker and left-handed patients.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
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To determine the depression (and so the effect of the treatment)we use the 10-item Montgomery Asberg Depression Rating Scale (MADRS)and we measure before tms (T=0), at week 1 (T=1), at week 2 (T=2), at week 4 (T=3), at week 8 (T=4), at week 14 (T=5)
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Besides the MADRS we use the BDI (Beck depression Inventory, the Hamillton deppression and anxiety scale)
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Secondary Outcome Measures
Outcome Measure |
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-Changes in anxiety
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-.Autonomic changes
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-.changes in the emotioneal attention, in the emotional memory en in de emotional recognition.
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-.Biochemical changes
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-.Changes in the EEG
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>> measured before tms and after (at T=0 and T=2)
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Collaborators and Investigators
Investigators
- Study Director: G.F Koerselman, prof. dr., st Lucas Andreas Ziekenhuis
Study record dates
Study Major Dates
Study Start
Study Completion
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- CCMO03.3741/SH/P03.1231L
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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