Plasma Brain Natriuretic Peptide Levels in Pregnancy

October 1, 2020 updated by: Oklahoma State University Center for Health Sciences
To evaluate the maternal blood concentrations of brain natriuretic peptide (BNP) during the second and third trimesters of a normal pregnancy. We will attempt to define a normal range for pregnancy and any outliers that may serve as markers for abnormal cardiovascular physiology.

Study Overview

Status

Completed

Conditions

Detailed Description

The brain natriuretic peptide (BNP) is a useful marker for volume overload, increased filling pressures and stretching of the myocardium. The current literature contains limited and unreliable information regarding normal BNP values in pregnancy. After baseline echocardiogram to detect individuals with asymptomatic structural defects, the participants will submit to 3 blood draws during the second and third trimester and at delivery to determine normal pregnancy values.

Study Type

Observational

Enrollment (Anticipated)

50

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Oklahoma
      • Tulsa, Oklahoma, United States, 74127
        • Oklahoma State University Center for Health Sciences

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 40 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

Female

Sampling Method

Non-Probability Sample

Study Population

Healthy pregnant women, 18-40

Description

Inclusion Criteria:

  • women age 18 to 40
  • second trimester of pregnancy

Exclusion Criteria:

  • known cardiac or valvular disease,
  • atrial fibrillation or other arrhythmia,
  • pulmonary hypertension,
  • chronic hypertension,
  • hypertensive disorders of pregnancy,
  • morbid obesity (BMI > 40 kg/meter squared)
  • history of sleep apnea
  • multiple gestation
  • known renal dysfunction
  • medications known to affect cardiac function
  • current or past abnormal echocardiogram

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
1
Healthy pregnant women, 18-40

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Oklahoma State University Center for Health Sciences

Investigators

  • Study Chair: Kimberly A Sorensen, DO, Oklahoma State University Center for Health Sciences
  • Principal Investigator: John M Beal, DO, Oklahoma State University Center for Health Sciences

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

August 1, 2006

Study Completion (Actual)

June 1, 2008

Study Registration Dates

First Submitted

May 9, 2006

First Submitted That Met QC Criteria

May 10, 2006

First Posted (Estimate)

May 11, 2006

Study Record Updates

Last Update Posted (Actual)

October 5, 2020

Last Update Submitted That Met QC Criteria

October 1, 2020

Last Verified

October 1, 2020

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2005008

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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