- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00452803
Pre-operative Chemotherapy Versus Concurrent Chemoradiotherapy in N2 Positive IIIA Non Small Cell Lung Cancer (NSCLC)
A Randomized Phase II Study Preoperative Chemotherapy Versus Preoperative Concurrent Chemoradiotherapy for Patients With Biopsy-Proven N2 Stage IIIA Non-Small Cell Lung Cancer
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Preoperative Therapy Arm 1. (preoperative chemotherapy) Paclitaxel (90 mg/m2)on day 1 and 8 Cisplatin (40 mg/m2)on day 1 and 8. q 3 weeks, 2 cycles
Arm 2. (preoperative chemoradiotherapy) Paclitaxel (50 mg/m2)on day 1, 8, 15, 22 & 29 Cisplatin (20 mg/m2)on day 1, 8, 15, 22 & 29. Thoracic radiation therapy (TRT) 1.8 Gy daily, five times per week (45 Gy target dose in 5 weeks).
Postoperative Consolidation Chemotherapy:
Paclitaxel (90 mg/m2) on day 1 and 8. Cisplatin (40 mg/m2) on day 1 and 8. q 3weeks, 2 cycles
Study Type
Enrollment (Anticipated)
Phase
- Phase 2
Contacts and Locations
Study Contact
- Name: Heung Tae Kim, M.D.
- Phone Number: +82-31-920-1602
- Email: htkim@ncc.re.kr
Study Locations
-
-
Gyeonggi-do
-
Goyang-si, Gyeonggi-do, Korea, Republic of, 411-769
- Recruiting
- National Cancer Center, Korea
-
Sub-Investigator:
- Jae-Ill Zoo, M.D.
-
Sub-Investigator:
- Jong Mog Lee, M.D.
-
Sub-Investigator:
- Moon Soo Kim, M.D.
-
Sub-Investigator:
- Hyun-Sung Lee, M.D.
-
Sub-Investigator:
- Jin Soo Lee, M.D.
-
Sub-Investigator:
- Hyae Young Kim, M.D.
-
Sub-Investigator:
- Moon Woo Seong, M.D.
-
Sub-Investigator:
- Kyeong-Man Hong, M.D.
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Histologic or cytologic diagnosis of non-small cell lung cancer.
- Presence of biopsy-proven N2 stage IIIA, according to the American Joint Committee on Cancer (AJCC), with none of the mediastinal lymph nodes > 3 cm in largest diameter.
- Tumor amenable to surgical resection.
- At least one unidimensional measurable lesion meeting Response Evaluation Criteria in Solid Tumors (RECIST. 2000).
- No prior tumor therapy (surgery, radiotherapy, chemotherapy, immunotherapy, or any other type of tumor therapy).
- Performance status of 0-1 on ECOG scale.
- At least 18 years old.
- Patient compliance that allows adequate follow-up.
- Medical fitness of patients adequate for radical NSCLC surgery.
- Adequate organ function including the following:Adequate hematologic function: WBC count ≥ 4,000/uL, absolute neutrophil count (ANC) ≥ 1,500/uL, platelet count ≥ 100,000/uL, and hemoglobin ≥ 10 gm/dL.Adequate hepatic function: bilirubin ≤ 1.5 x UNL, ALT or AST ≤ 2.5 x UNL.Adequate renal function: creatinine ≤ 1.5mg/dL.
- Signed informed consent from patient or legal representative.12. Patients with reproductive potential must use an approved contraceptive method during and for 3 months after the study. Females with childbearing potential must have a negative urine hCG test within 7 days prior to study enrollment.
Exclusion Criteria:
- Concurrent administration of any other tumor therapy, including radiotherapy, chemotherapy, immunotherapy.
- Active uncontrolled infection.
- Serious concomitant disorders that would compromise the safety of patient or compromise the patient's ability to tolerate therapy.
- MI within preceding 6 months or symptomatic heart disease including unstable angina, congestive heart failure, or uncontrolled arrhythmia.
- Significant neurological or mental disorder.
- Second primary malignancy.
- Pregnant or nursing.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: study arm
pre-operative chemotherapy (Pac/Cis)
|
Paclitaxel 90mg/m2 + Cisplatin 40mg/m2 on D1 & 8 q 3weeks, Pre-OP & post-op : 2cycles (total 4 cycles)
|
Active Comparator: study arm 2
Pre-operative concurrent chemoradiation therapy
|
Paclitaxel 50mg/m2 + Cisplatin 20mg/m2 on D1 & 8 q 3weeks, Pre-OP & post-op : 2cycles (total 4 cycles)
Preoperative Thoracic radiation: 180cGy/fx, total: 4500cGy, 25fx
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
To estimate the time to recurrence
Time Frame: The interval from the date of randomization to the date to the date of the first objective evidence of recurrence or to the date of death, if before recurrence
|
The interval from the date of randomization to the date to the date of the first objective evidence of recurrence or to the date of death, if before recurrence
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
To estimate the overall survival
Time Frame: from the date of randomization to the date of death
|
from the date of randomization to the date of death
|
To assess the pathologic complete response rate and the complete resection rate
Time Frame: After surgery
|
After surgery
|
To estimate toxicities
Time Frame: from the first date of treatment to 30 days after the last dose of study drug
|
from the first date of treatment to 30 days after the last dose of study drug
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Heung Tae Kim, M.D., National Cancer Center, Korea
Study record dates
Study Major Dates
Study Start
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- NCCCTS-06-164
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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