- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00491465
The Role of Physical Activity in the Treatment of Children With Type 1 Diabetes. (4301)
Randomized,Controlled,Open,Cross-Over Intervention Study for Evaluating the Role of Physical Activity in the Treatment of Children With Type 1 Diabetes.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Randomized, controlled, open, comparative, cross-over, intervention study in 50 children with type 1 diabetes.
objectives:
Primary objective To evaluate the efficacy and safety of physical activity for metabolic control in children with type I diabetes.
Secondary objectives
- To characterize the severity and pattern of occurrence of hypo and hyperglycemic episodes during and after exercise program in type I diabetic children.
- To evaluate changes in insulin sensitivity during and after periods of exercise in type I diabetic children.
- To evaluate the short term effect of exercise on BMI and body composition in type I diabetic children.
- To evaluate the short term effect of exercise on lipid profile in type I diabetic children.
- To evaluate differences in self esteem and quality of life between exercising and non exercising type I diabetic children.
Randomization:
Children will be randomly allocated into two groups of 25.The study will be conducted in a crossover manner:one group starting with the intensive arm followed by the non intensive arm and vice versa.
methods:
- The study will have an intensive arm and a non intensive arm, each lasting 12 weeks.
- Children fulfilling the inclusion and exclusion criteria will be randomly assigned to two groups. Each group will include 25 patients.
- Participants will fill questionnaires regarding physical activity.
- The first group will start with the intensive arm, followed by one month washout, and then the non intensive arm.
- The second group will start the study with the non intensive arm, followed by one month washout and then the intensive arm .
- The intensive arm will consist of an exercise program which will include high intensity progressive exercise (75% maximum age adjusted heart rate HRmax) 3 days a week for 90 minutes. The 90 min exercise will be a combination of aerobic exercise 45min. and resistance exercise 45 min.
- The exercise program will be planned and carried out by professional sports instructors.
- During the non intensive arm the participants will resume regular daily activity. They will keep records of their weekly physical activity and will get a weekly phone call from the treating doctor, addressing specifically physical activity performed during the past week and glucose levels before and after exercise.
- The following parameters will be measured for both groups at the beginning and the end of the intensive and non intensive arm and once again 12 weeks afterwards : Weight, height, pulse, blood pressure, waist circumference, skin folds, HbA1C , fructosamine ,3 days CGMS +3 day SBGM profile (will be measured to 40% of participants chosen randomly) ,total daily insulin dose ,blood sample for fasting lipid profile ,Body impedance and BMR , self esteem and quality of life questionnaires .
- Study participants will be required to measure blood glucose by glucometer at least 4 times a day and to record hypo and hyperglycemic events and their severity.
15.Both children and investigators will be blinded to CGMS results. 16.During the 3 day CGMS recording, the children's parents will be asked to monitor SBGM once during the night (in the intensive arm, following the exercise day).
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Ravital Nimri, MD
- Phone Number: direct 972-39253778
- Email: ravitaln@clalit.org.il
Study Locations
-
-
-
Petach-Tikva, Israel
- Schnider Children's medical center
-
Principal Investigator:
- Ravital Nimri, MD
-
Principal Investigator:
- Moshe Phillip, Prof.
-
Sub-Investigator:
- Rachel Frumkin, MD
-
Sub-Investigator:
- Neomi Weintrob, MD
-
Sub-Investigator:
- Shlomit Shalitin, MD
-
Sub-Investigator:
- Nesia Nagelberg, MA
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Type I diabetic children
- Tanner stage II-IV
- Patients of the Schneider's national institute of childhood diabetes. Duration of diabetes
- more than one year.
- HbA1C between 8 and 12 at time 0.
- Mandatory 4 daily self blood glucose measurements and daily recording of adverse events.
- A signed informed consent of the parents and child.
Exclusion Criteria:
- Additional chronic significant disease such as cardiac, liver, renal disease .
- Children who exercise regularly more than 180 min per week.
- Cardiac symptoms: history of chest pain , syncope , palpitations or dyspnea during exercise.
- Eating disorders.
- Participation in a study during the past month.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Supportive Care
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: None (Open Label)
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
HbA1C
Time Frame: 0,3 monthes
|
0,3 monthes
|
fructosamine
Time Frame: 0,3 monthes
|
0,3 monthes
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Body composition & BMR
Time Frame: 0,3 monthes
|
0,3 monthes
|
Self esteem & QOL questionnaires
Time Frame: o, 3 monthes
|
o, 3 monthes
|
3 days CGMS & SBGM profile
Time Frame: 0,3 monthes
|
0,3 monthes
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Ravital Nimri, MD, Rabin Medical Center
Study record dates
Study Major Dates
Study Start
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- rmc074301ctil
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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