- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00737984
Improving the Pregnancy Rate With Endometrial Sampling Before Intrauterine Insemination
April 19, 2012 updated by: Mohammed Agdi, McGill University Health Centre/Research Institute of the McGill University Health Centre
Endometrial sampling improves the pregnancy rates in superovulation-IUI cycles
Study Overview
Status
Terminated
Conditions
Intervention / Treatment
Detailed Description
Endometrial sampling is performed using the standard technique in the outpatient department.
Similarly, superovulation with gonadotrophins will be performed according to our standard practice.Endometrial sampling will be done in the follicular phase not later than day 10 of the cycle.
Endometrial sampling will be performed using Pipelle sampling catheter.
The Pipelle is inserted gently through the cervical canal into the uterine cavity and advanced slowly till just resistance felt by the operator.
Then, the piston is withdrawn to create negative suction and gentle movement of Pipelle up and down in the uterine cavity is performed while it is against the uterine wall.
The Pipelle catheter is withdrawn gently and any obtained specimen will be sent for histopathological examination.
Study Type
Interventional
Enrollment (Actual)
9
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Quebec
-
Montreal, Quebec, Canada, H3A 1A1
- McGill University Health Center
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
No
Genders Eligible for Study
Female
Description
Inclusion Criteria:
- All women undergoing superovulation with gonadotrophins and intrauterine insemination.
- All women with cervical factor, mild male factor and/or unexplained infertility.
- At least one patent Fallopian tube.
Exclusion Criteria:
- Bilateral tubal disease
- Severe male factor infertility
- Intrauterine pathology (submucosal fibroid, endometrial polyp, adhesions)
- Women with positive cervical culture and/or acute vaginal infection
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
No Intervention: 1
Group 1 patients will receive standard superovulation-IUI treatment without endometrial sampling
|
|
Active Comparator: 2
Group 2 patients will receive standard superovulation-IUI treatment with endometrial sampling performed in the preceding cycle.
It will be done in the follicular phase not later than day 10 of the cycle
|
Endometrial sampling performed in the preceding cycle.
It will be done in the follicular phase not later than day 10 of the cycle
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
The rate of clinical pregnancy
Time Frame: 24 months
|
24 months
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Togas Tulandi, MD, MHCM, McGill University Health Centre/Research Institute of the McGill University Health Centre
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Raziel A, Schachter M, Strassburger D, Bern O, Ron-El R, Friedler S. Favorable influence of local injury to the endometrium in intracytoplasmic sperm injection patients with high-order implantation failure. Fertil Steril. 2007 Jan;87(1):198-201. doi: 10.1016/j.fertnstert.2006.05.062.
- Barash A, Dekel N, Fieldust S, Segal I, Schechtman E, Granot I. Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization. Fertil Steril. 2003 Jun;79(6):1317-22. doi: 10.1016/s0015-0282(03)00345-5.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
August 1, 2008
Primary Completion (Actual)
August 1, 2011
Study Completion (Actual)
August 1, 2011
Study Registration Dates
First Submitted
August 18, 2008
First Submitted That Met QC Criteria
August 19, 2008
First Posted (Estimate)
August 20, 2008
Study Record Updates
Last Update Posted (Estimate)
April 20, 2012
Last Update Submitted That Met QC Criteria
April 19, 2012
Last Verified
October 1, 2009
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- SDR-08-004
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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