Study of Immediate Post-Operative Intravesical Instillation of Chemophase® in Patients With Superficial Bladder Cancer (IPOP)

Phase I Safety and Tolerability Study of Immediate Post-Operative Intravesical Instillation of Chemophase® (Recombinant Human Hyaluronidase in Combination With Mitomycin) in Patients With Non-Muscle-Invasive Bladder Cancer

The purpose of this research study is to test the safety and tolerability of an experimental drug, Chemophase, a combination of recombinant human hyaluronidase, (an investigational synthetic enzyme also known as rHuPH20), and mitomycin (MMC) in the treatment of superficial bladder cancer when instilled intravesically immediately after TURBT (transurethral resection of bladder tumor).

Study Overview

• Status: Completed
• Conditions: Superficial Bladder Cancer
• Intervention / Treatment: Drug: Chemophase

Detailed Description

Patients will be screened and enrolled prior to undergoing standard of care TURBT for known or suspected Stage Ta, T1 or Tis bladder cancer of any histological grade requiring TURBT and who are believed to be candidates for IPOP intravesical chemotherapy regardless of the need for further intravesical therapy. Within 6 hours after completion of TURBT, patients will be administered a single IPOP intravesical instillation of Chemophase with a one-hour dwell time. At the end of the one-hour dwell time, the patient will be asked to fully void or, if an intravesical catheter has been left in place, the bladder will be fully drained via the catheter. Patients will return at 1 and 2 weeks post instillation for follow up visits for safety and for a cystoscopy at day 85 (per standard of care). Safety and tolerability will be assessed through physical examinations, vital signs, cystoscopy, hematology (CBC), adverse event reporting, and measurements of plasma levels of MMC.

• Study Type: Interventional
• Enrollment (Actual): 14
• Phase: Phase 1

Contacts and Locations

Study Locations

• United States
  • Arizona
    • Phoenix, Arizona, United States, 85032
      • BCG Oncology, PC
  • California
    • Anaheim, California, United States, 92801
      • Advanced Urology Medical Center
    • La Mesa, California, United States, 91942
      • MedResearch
  • Florida
    • Gainesville, Florida, United States, 32608
      • Malcolm Randall Veterans Administration
    • New Port Richey, Florida, United States, 34655
      • Advanced Research Institute, Inc.

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Patient with histologically confirmed or suspected (based on cystoscopy) initial presentation or recurrence of Stage Ta, T1, or Tis transitional cell bladder cancer of any histological grade requiring TURBT.
• Patient believed to be a candidate for immediate post-operative chemotherapy regardless of the need for additional intravesical therapy.
• ECOG performance status of Grade 0 or 1.
• Age ≥ 18 years.
• A negative urine or serum pregnancy test (if female of child-bearing potential) within 14 days prior to Day 1/Week 1.
• Acceptable liver function within 14 days prior to Day 1/Week 1 defined as:
• Total bilirubin ≤ 1.5 times upper limit of normal (ULN), and
• AST (SGOT), ALT (SGPT), and alkaline phosphatase ≤ 2.5 times ULN.
• Acceptable renal function within 14 days prior to Day 1/Week 1 defined as serum creatinine ≤ 1.5 x ULN.
• Acceptable hematologic status within 14 days prior to Day 1/Week 1 defined as:
• Absolute neutrophil count (ANC) ≥ 1,500/dL,
• Platelet count ≥ 100,000/dL, and
• Hemoglobin ≥ 10.0 g/dL.
• Urinalysis showing no clinically significant abnormalities, except those attributable to bladder cancer.
• For men and women of child-producing potential, agreement to use an effective contraceptive method during the study from enrollment until 2 weeks after the administration of study drug.
• Signed, written, IRB-approved informed consent.

Exclusion Criteria:

• Large resected area (estimated total area > 50 cm²) or suspected deep resection, even in the absence of signs of perforation beyond the muscularis propria or ongoing significant bleeding.
• Known or suspected bladder perforation during TURBT.
• Failure to completely resect all cancerous lesions or suspected presence of muscle-invasive cancer (Stage T2 or higher).
• Previous diagnosis or current presence of bladder fibrosis/contracture, or total bladder capacity estimated at cystoscopy or by other means to be < 150 mL.
• Urinary incontinence or severe irritative voiding symptoms such as urgency, frequency, or nocturia of a severity that would compromise the ability of the patient to retain the study drug intravesical instillation for one hour.
• Bladder cancer recurrence less than 3 months after a previous TURBT.
• Major surgery, other than TURBT or diagnostic surgery, within 28 days prior to Day 1/Week 1.
• Known active, uncontrolled bacterial, viral, or fungal infections, including urinary tract infection.
• Any intravesical therapy within 3 months prior to Week 1/Day 1.
• Systemic therapy including radiation therapy, surgery, chemotherapy, or investigational therapy within one month prior to Day 1/Week 1 (two months for nitrosoureas or MMC), unless given as standard treatment for bladder cancer and provided that patient is free of all treatment-related toxicities as of Day 1/Week 1.
• Known infection with HIV.
• Known active infection with hepatitis B or hepatitis C virus.
• Serious disease (e.g., hydronephrosis, liver failure, or other conditions) that could compromise protocol objectives in the opinion of the Investigator and/or the Sponsor (Halozyme).
• History of hypersensitivity or idiosyncratic reaction to, or other contraindication to, MMC.
• Known allergy to bee or vespid venom.
• Known coagulation disorder or bleeding tendency.
• Ongoing treatment with heparin or other anticoagulation therapy, or anticipation of such therapy during the treatment period in this study.
• Unwillingness or inability to comply with procedures required in this protocol.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Arm 1; Single arm, open label, single dose, intravesical instillation of Chemophase (combination of rHuPH20 and mitomycin) for appropriate superficial bladder cancer patients within 6 hours of TURBT.	Drug: Chemophase; 40 mg mitomycin with 800,000 U rHuPH20 total volume of 40 mL instilled

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Safety and Tolerability of immediate post-operative instillation of Chemophase.	Day 1 instillation, and weeks 1, 2, and 12

Secondary Outcome Measures

Outcome Measure	Time Frame
Assess plasma levels of mitomycin (MMC) after IPOP intravesical instillation.	Hours 1, 2 and 3 post-instillation

Collaborators and Investigators

• Sponsor: Halozyme Therapeutics
• Investigators: Principal Investigator: Donald Lamm, M.D., BCG Oncology, PC

Study record dates

Study Major Dates

• Study Start: October 1, 2008
• Primary Completion (Actual): March 1, 2009
• Study Completion (Actual): August 1, 2009

Study Registration Dates

• First Submitted: October 29, 2008
• First Submitted That Met QC Criteria: October 29, 2008
• First Posted (Estimate): October 31, 2008

Study Record Updates

• Last Update Posted (Estimate): February 8, 2010
• Last Update Submitted That Met QC Criteria: February 5, 2010
• Last Verified: February 1, 2010

More Information

Terms related to this study

• Keywords: rHuPH20; Mitomycin; Non-Muscle-Invasive Bladder Cancer; recombinant human hyaluronidase; Superficial Bladder Cancer; Chemophase®
• Additional Relevant MeSH Terms: Neoplasms; Urologic Neoplasms; Urogenital Neoplasms; Neoplasms by Site; Urologic Diseases; Urinary Bladder Diseases; Urinary Bladder Neoplasms
• Other Study ID Numbers: HZ2-08-01