- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00791245
Post Market Study of DeNovo NT, Natural Tissue Graft
August 7, 2014 updated by: Zimmer Orthobiologics, Inc.
A Post Market Study of Articular Cartilage Defects of the Knee Treated Wtih DeNovo NT, Natural Tissue Graft
The purpose of this post market study is to evaluate surgical implantation technique and the quality of repair of the cartilage defect with particulated juvenile cartilage in the human knee joint.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
The intent of this post market study is to assess the clinical outcomes of DeNovo NT, a particulated juvenile cartilage tissue for the treatment of one or two contained lesion(s) equal to an ICRS Grade 3a, 3b, 3c, 3d of the femoral condyle or trochlear groove and OCD lesions (Grade 4a) with healed bone base, which is non sclerotic and no loss of bone greater thank 6mm measured from the surrounding subchondral plate.
Study Type
Observational
Enrollment (Actual)
25
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
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Illinois
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Chicago, Illinois, United States, 60612
- Midwest Orthopaedics at Rush
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Indiana
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Indianapolis, Indiana, United States, 46237
- OrthoIndy
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New Mexico
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Albuquerque, New Mexico, United States, 87106
- New Mexico Orthopaedic Association, PC
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-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 55 years (ADULT)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
Clinical population
Description
Inclusion Criteria:
- Voluntary signature of the IRB approved Informed Consent
- Male or female subjects between the ages of 18 to 55 years
If female:
- Actively practicing a contraception method, or
- Practicing abstinence, or
- Surgically sterilized, or
- Postmenopausal
- Pretreatment arthroscopic confirmation indicating one or two contained lesion(s) are equal to an ICRS Grade 3a, 3b, 3c, 3d of the femoral condyle or trochlear groove and OCD lesions (Grade 4a) with healed bone base, which is non sclerotic and no loss of bone greater than 6mm measured from the surrounding subchondral plate,
- Has peripheral cartilage debridement to healthy cartilage that results in a lesion(s) with an area of greater than or equal to 1 cm squared and less than or equal to 5 cm squared,
- PCL, LCL and MCL in the affected knee are stable and the ACL is stable or can be stabilized as a concomitant procedure,
- Ipsilateral knee compartment has intact menisci (or requires partial meniscectomy resulting in stable menisci),
- The contralateral knee is asymptomatic, stable and fully functional,
- Must be physically and mentally willing and able to comply with post-operative rehabilitation and routinely schedule clinical and radiographic visits through 24 months.
Exclusion Criteria:
Clinical and/or radiographic disease diagnosis of the indexed affected joint that includes:
- Osteoarthritis or avascular necrosis,
- Rheumatoid arthritis, or history of septic or reactive arthritis,
- Gout or a history of gout or pseudogout in the affected knee,
- Osteochondritis dissecans of the knee with significant bone loss (greater than 6mm deep from the subchondral plate),
- Associated damage to the underlying subchondral bone requiring an osteochondral graft,
- History of secondary arthropathies (i.e. sickle cell disease, hemochromatosis, or autoimmune disease),
- Uncontrolled diabetes,
- Displays a high surgical risk due to unstable cardiac and/or pulmonary disease,
- Has HIV or other immunodeficient state including subjects on immunosuppressant therapies, or has significant illness (metastasis of any type) that decreases the probability of survival to the 2 year endpoint,
- Is at substantial risk for the need of organ transplantation, such as renal insufficiency,
- Is pregnant or breast-feeding,
- Body Mass Index >35 (BMI=kg/m2),
- Has bipolar articular cartilage involvement or kissing lesions of the ipsilateral compartment, described as tibial or patellar lesions in the same compartment with greater than ICRS Grade 2 chondrosis,
- Is participating concurrently in another clinical trial, or has participated ina clinical trial within 30 days of surgery,
- Is receiving prescription pain medication other than NSAIDs or acetaminophen for conditions unrelated to the index knee condition, chronic use of anticoagulants, or taking corticosteroids,
- Has a neuromuscular, neurosensory, or musculoskeletal deficiency that limits the ability to perform objective functional assessment of either knee,
- Active joint infection,
- Prior total meniscectomy of either knee,
- Radiographically has >5 degrees of malalignment as measured from the hip, knee and ankle mechanical axis,
- Has received, within the past three months intra-articular hyaluronic acid therapy or cortisone injections in the index knee,
- Prior realignment surgery in the affected knee within the past 6 months,
- Failed microfracture treatment performed less than 12-months before baseline,
- Is receiving workman's compensation or currently involved in litigation relating to the index knee,
- Has history of alcoholism, medication or intravenous drug abuse, psychosis, is a prisoner, has a personality disorder(s), poor motivation, emotional or intellectual issues that would likely make the subject unreliable for the study, or any combination of variables in the investigator's judgement that should exclude a potential subject,
- Had or have an aneurysm clip implanted, intraocular foreign bodies (commonly seen in welders), subcutaneous metal shards (found in sheet metal workers), or some shrapnel; additionally no cardiac pacemaker, defibrillator, implanted neurostimulator (TENS implants), some prosthetic heart valve (especially mitral valve), cochlear implant or other hearing aid, or has a tendency of claustrophobia. Have tattoos that may contain iron-based dyes.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
1
DeNovo NT
|
Particulated Juvenile Cartilage Allograft
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
KOOS
Time Frame: Preoperatively, postoperatively at 10 Days, 3, 6, 12, 18 & 24 Months
|
Preoperatively, postoperatively at 10 Days, 3, 6, 12, 18 & 24 Months
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
IKDC Subjective Knee Evaluation
Time Frame: Preopertively, postoperatively at 10 Days, 3, 6, 12, 18, & 24 Months
|
Preopertively, postoperatively at 10 Days, 3, 6, 12, 18, & 24 Months
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
January 1, 2006
Primary Completion (ACTUAL)
August 1, 2012
Study Completion (ACTUAL)
August 1, 2012
Study Registration Dates
First Submitted
November 13, 2008
First Submitted That Met QC Criteria
November 13, 2008
First Posted (ESTIMATE)
November 14, 2008
Study Record Updates
Last Update Posted (ESTIMATE)
August 11, 2014
Last Update Submitted That Met QC Criteria
August 7, 2014
Last Verified
August 1, 2014
More Information
Terms related to this study
Other Study ID Numbers
- ISTO - DeNovo NT 03-07-02
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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